me 1

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.

Histone H3K27Me1 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Monomethylation of histone H3 at lysine 27 is associated with actively transcribed genes and positively correlates with H3K36 trimethylation. Levels of H3K27Me1 are increased in tumor tissue isolated from patients with metastatic hormone-na ve and castration-resistant prostate cancer. Histone H3K27Me1 (23-34) has been used in epitope mapping of the lupus-derived monoclonal antibody BT164.

MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 (compound 19-2) serves as a synthetic intermediary for the creation of the drug-linker conjugate, MC-GGFG-AM-(10Me-11F-Camptothecin), utilized in the synthesis of ADCs (Antibody-Drug Conjugates). This intermediate allows for the incorporation of functional groups.

1-(3,4-Dihydroxyphenyl)-1-propanol, 3?,4?-Di-Me et is a useful organic compound for research related to life sciences and the catalog number is T130490.

MV-1-NH-Me, an MV-1-derived IAP ligand, connects to an ABL inhibitor through a linker, resulting in the formation of SNIPER[1].

Thalidomide-1-Me,4-OH is an alcohol-like analogue of Thalidomide. Thalidomide acts as a ligand for E3 ubiquitin ligase, which ubiquitinates proteins, leading to their eventual degradation via proteolysis.

Thalidomide-1-Me,5-F is a fluorinated E3 ligase activator utilized for further derivatization through SNAr (nucleophilic aromatic substitution).

Thalidomide-1-Me-5-NH2 is an aminated analog of Thalidomide. This type of E3 ligase activator can be utilized in the design of PROTAC molecules through derivatization on its amine group.

E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid receptor (KOR) agonist [1].

CRBN ligand-1-piperidine-Me is an E3 ubiquitin ligase ligand-linker conjugate.

H3K4(Me) (1-20) is a histone peptide; H3K4me is a complexly regulated post-translational modification closely associated with enhancers and promoters at active transcription genomic sites.

The COVID-19 Spike Protein mRNA, responsible for expressing the COVID-19 spike protein, is crucial for evaluating RNA delivery, translation efficiency, and cell viability. Positioned on the membrane surface, this spike protein facilitates virus entry into cells by binding to host cell membrane receptors and promoting membrane fusion. It serves as a significant action site for neutralizing antibodies and represents a primary focus in vaccine development [1].

eGFP mRNA encodes the green fluorescent protein, originally derived from the jellyfish Aequorea victoria, and serves as a widely utilized direct detection reporter in mammalian cell culture. This protein produces a distinct bright green fluorescence, with an emission peak at 509 nm.

Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.

Neu5GcAc[1Me,478Ac,9N3]-β-SPh is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Neu5Troc[1Me,4789Ac]α(2-3)Gal[26Bn]-β-MP is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

4ME 16:0 PA sodium is a bis(monoacylglycero)phosphate lipid.

4ME 16:0 Diether DG is a type of dialkylglycerolipid.

4ME 16:0 Diether PC is a diacylglycerol.

4ME 16:0 PS sodium is a type of bisphospholipid.

4ME 16:0 Diether PE is a phospholipid used in the preparation of lipid nanoparticles for drug delivery.

4ME 16:0 PG monosodium is a diacylglycerol.

AI-10-47 (1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47) is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM).

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α), effectively inhibiting both its RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).