bca

BCA is 2,2-Biquinoline-4,4-dicarboxylic acid disodium salt.

Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.

Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33 73 uM for TET1 2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.

BCAT-IN-4 is a potent BCAT inhibitor with an IC50 value of 2.35 μM for hBCATc. BCAT-IN-4 has anticancer activity and can be used to study pancreatic ductal adenocarcinoma.

ABCA1 inducer 1, a non-lipid inducer of ABCA1, enhances ABCA1 expression in E3 4FAD mice expressing human APOE 3 4, augments the lipidation of apolipoprotein (APOE), and reverses various Alzheimer's disease (AD) phenotypes without increasing triglycerides.

BCATc Inhibitor 2 exhibited an IC50 of 0.8 microM in the hBCATc assays; it is an active and selective inhibitor. BCATc Inhibitor 2 also blocked calcium influx into neuronal cells following inhibition of glutamate uptake, and demonstrated neuroprotective e

BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia.

Bismuth subcarbonate, also known as bismuth carbonate oxide, is a versatile semiconductor compound based on bismuth, commonly utilized for its antibacterial properties, as well as in various applications such as sensors, super capacitors, and photocatalysts. Additionally, bismuth subcarbonate serves as a protective agent against gastric acid erosion, particularly in the treatment of gastric ulcers[1][2].

BCAT-IN-1 is an orally active and selective BCATm inhibitor and a potential BCAT2 modulator, used in studies of metabolic diseases.

Bobcat339 hydrochloride is a selective 10 11 translocation (TET) dioxygenase inhibitor that inhibits TET1 and TET2.Bobcat339 hydrochloride induces TET3 protein degradation and also stimulates the expression of AGRP, NPY, and VGAT in a TET3-dependent manner in mouse and human neuronal cells. VGAT expression, which can be used to study transient anorexia nervosa.

CNBCA, a selective and potent competitive inhibitor of the SHP2 enzyme, exhibits an IC50 value of 0.87 μM. It binds to the full-length SHP2, effectively inhibiting its enzyme activity, as well as impeding pAkt and pERK1 2. Furthermore, CNBCA suppresses the proliferation of BT474 and MDA-MB468 cells, indicating potential utility in breast cancer research [1].

HBcAg (core antigen) is a hepatitis B viral protein. It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person.

Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro.

4-Acetylphenylboronic acid acts as an effective inhibitor targeting carbonic anhydrase II (CAII), displaying inhibitory concentrations (IC50) of 246 μM for bovine CAII (bCA II) and 281.40 μM for human CAII (hCA II).

DSPE-PEG-Amine, MW 3400 (ammonium), is a phosphoethanolamine involved in the synthesis of liposomal delivery systems. The compound's amino group can be converted into an aromatic aldehyde to react with acetone-protected aromatic hydrazine on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes are formed by creating bis-arylhydrazone (BAH) linkages with the target enzyme molecules, resulting in a liposome-BAH-BCA conjugate that can catalyze the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 5000 (ammonium), is a phosphatidylethanolamine that plays a role in the synthesis of liposomes for delivery systems. The amine group in DSPE-PEG-Amine, MW 5000 (ammonium) can be transformed into an aromatic aldehyde, which reacts with acetone-protected aromatic hydrazine on the surface of bovine carbonic anhydrase (BCA) molecules. The liposomes form bisaryl hydrazone (BAH) conjugates with the target enzyme molecules, resulting in liposome-BAH-BCA conjugates that can catalyze the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of lipid-based delivery systems. The amine group on DSPE-PEG-Amine, MW 10000 (ammonium) can react with aromatic aldehydes on the surface of bovine carbonic anhydrase (BCA) molecules, forming bisarylhydrazones (BAH) with the target enzyme. This interaction results in a liposome-BAH-BCA conjugate capable of catalyzing the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 1000 (ammonium) is a phosphatidylethanolamine used in the synthesis of lipid-based delivery systems, such as liposomes. The amine group of DSPE-PEG-Amine can be converted into an aromatic aldehyde, which reacts with acetone-protected aromatic hydrazine on the surface of bovine carbonic anhydrase (BCA) molecules. The liposomes form a conjugate with the enzyme molecule through bis-aryl hydrazone (BAH), resulting in a liposome-BAH-BCA conjugate. This conjugate catalyzes the hydration of carbon dioxide into bicarbonate.