Search Result

Search Results for " parp "

Targets

182

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T12365	PARP/PI3K-IN-1		PARP , PI3K
	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ...		PARP , PI3K
T78182	PARP-1-IN-4		Others , PARP
	PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.		Others , PARP
T62281	PARP-1-IN-2		PARP
	PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel...		PARP
T78157	PARP-1-IN-3		Apoptosis , PARP
	PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell...		Apoptosis , PARP
T40310	PARP/EZH2-IN-1	PARP/EZH2-IN-1
	PARP/EZH2-IN-1 is a novel compound that functions as a dual inhibitor for both PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for the treatment of triple-negative breast cancer with wild-type B...
T73027	PARP-2-IN-3		Apoptosis , PARP
	PARP-2-IN-3 is used as a potent PARP-2 inhibitor (IC50=0.07 μM) with anti-tumor activity that induces apoptosis and necrosis in cancer cells, and can be used for the study of breast cancer.CAS 번호128-52-56-8		Apoptosis , PARP
T6329	3-Aminobenzamide	3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001	PARP
	3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion.		PARP
T12364	PARP-2-IN-1		Others
	PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).		Others
T72862	PARP-2/1-IN-2
	PARP-2/1-IN-2, an enantiomer of Veliparib, serves as a potent inhibitor of PARP, demonstrating inhibition constants (Kis) of 2 nM for PARP-2 and 5 nM for PARP-1. This compound exhibits a half-maximal effective concentrat...
T79330	PARP-1-IN-13		PARP
	PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand breaks. It induces apoptosis in cancer cells via the mitochondri...		PARP
T61798	PARP-1-IN-1
	PARP-1-IN-1 is a highly selective and orally active inhibitor of the enzyme PARP-1, with an IC50 value of 0.96 nM. It exhibits excellent tolerance and demonstrates significant activity in a single dose in the MDA-MB-436 ...
T79647	VEGFR/PARP-IN-1		PARP
	VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. Thi...		PARP
T62508	PARP-1/2-IN-1
	PARP-1-/2-IN-1 is a potent inhibitor of PARP-1 (IC50: 0.51 nM) and PARP-2 (IC50: 23.11 nM).
T61962	PARP-1/HDAC-IN-1
	PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1/HDAC6, with IC50 of 68.90 nM and 510 nM respectively. PARP-1/HDAC-IN-1 has anti-cancer, anti-migration and anti-angiogenesis activities.
T74173	PROTAC PARP/EGFR ligand 1
	PROTAC PARP/EGFR ligand 1 is a potent compound utilized in the creation of dual PARP-EGFR degraders through Proteolytic Targeting Chimera (PROTAC) technology [1].
T78787	PARP-1/2-IN-2		PARP
	PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound...		PARP
T9610	PARP1-IN-5 dihydrochloride		PARP
	PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.		PARP
T6842	G007-LK		PARP , Wnt/beta-catenin
	G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.		PARP , Wnt/beta-catenin
T15639	K-756		PARP , Wnt/beta-catenin
	K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 and TNKS2 (IC50s: 31 and 36 nM, respectively).		PARP , Wnt/beta-catenin
T8964	G244-LM		Others , PARP
	G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.		Others , PARP
T16761	RK-287107		Others , PARP
	RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).		Others , PARP
T21524	4-amino-1,8-Naphthalimide		PARP
	4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM		PARP
T1807	JW 55	JW55	PARP , Wnt/beta-catenin
	JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).		PARP , Wnt/beta-catenin
T3168	MN-64	MN64	Others , PARP , Wnt/beta-catenin
	MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.		Others , PARP , Wnt/beta-catenin
T6197	PJ34		PARP
	PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.		PARP
T2484	AZD-2461		PARP
	AZD2461 is a novel PARP inhibitor.		PARP
T6181	UPF 1069		PARP
	UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.		PARP
T6578	ME0328		PARP
	ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.		PARP
T6768	AZ6102		PARP , Wnt/beta-catenin
	AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.		PARP , Wnt/beta-catenin
T6253	Talazoparib	LT-673,BMN-673	PARP
	Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).		PARP
T22264	AZ9482		PARP
	AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.		PARP
T3062	WIKI4		PARP , Wnt/beta-catenin
	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).		PARP , Wnt/beta-catenin
T50098	TIQ-A		PARP
	TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m...		PARP
T7042	1,5-Isoquinolinediol		PARP
	1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...		PARP
T4472	NMS-P118		PARP
	NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.		PARP
T5058	Pamiparib	BGB-290	PARP
	Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b...		PARP
T6339	AG14361	AG 14361,AG-14361	PARP
	AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).		PARP
T9165	AZD5305		PARP
	AZD5305 is a potent, selective and oral active PARP inhibitor.		PARP
T9593	Senaparib	IMP4297	PARP
	Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.		PARP
T4471	E7449	Stenoparib,UNII-9X5A2QIA7C	Others , PARP
	E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.		Others , PARP
T22414	RBN012759		PARP
	RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.		PARP
T3649	BGP-15	BGP15,BGP-15 2HCl	PARP
	BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.		PARP
T22749	DR2313	DR 2313	PARP
	DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.		PARP
T12695	RBN-2397		PARP
	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.		PARP
T5399	GeA-69		PARP
	GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).		PARP
T9497	Niraparib tosylate monohyrate		PARP
	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting...		PARP
T7896	BYK204165	RT-017290	PARP
	BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)		PARP
T9430	Venadaparib	NOV140101,IDX-1197	PARP
	Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the...		PARP
T8478	SC-43		Apoptosis , Phosphatase , STAT
	SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.		Apoptosis , Phosphatase , STAT
T2124	PJ34 hydrochloride	PJ34 HCl	PARP
	PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2.		PARP

Compounds

Target: Others, PARP

Target: Apoptosis, PARP

PARP/EZH2-IN-1

T40310

Synonym: PARP/EZH2-IN-1

Target: Apoptosis, PARP

3-Aminobenzamide

T6329

Synonym: 3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001

PROTAC PARP/EGFR ligand 1

PARP1-IN-5 dihydrochloride

Target: PARP, Wnt/beta-catenin

K-756

T15639

Synonym:

Target: PARP, Wnt/beta-catenin

G244-LM

T8964

Synonym:

Target: Others, PARP

RK-287107

T16761

Synonym:

Target: Others, PARP

4-amino-1,8-Naphthalimide

Target: PARP, Wnt/beta-catenin

MN-64

T3168

Synonym: MN64

Target: Others, PARP, Wnt/beta-catenin

Target: PARP, Wnt/beta-catenin

Talazoparib

T6253

Synonym: LT-673,BMN-673

Target: PARP, Wnt/beta-catenin

Synonym: AG 14361,AG-14361

Synonym: Stenoparib,UNII-9X5A2QIA7C

Target: Others, PARP

Synonym: BGP15,BGP-15 2HCl

Niraparib tosylate monohyrate

Synonym: NOV140101,IDX-1197

Target: Apoptosis, Phosphatase, STAT

Cat No.	Product Name	Synonyms	Targets
T8184	Fucosterol		PARP , Endogenous Metabolite , PPAR
	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.		PARP , Endogenous Metabolite , PPAR
T7982	3,6-Dihydroxyflavone		Others
	3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.		Others
T13795	Nicotinamide riboside		Sirtuin
	Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.		Sirtuin
T7443	4'-Methoxychalcone		PARP , PPAR
	4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.		PARP , PPAR
T8150	Nudifloramide	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide	PARP , Endogenous Metabolite
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).		PARP , Endogenous Metabolite
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T6780	Benzamide	Amid kyseliny benzoove,Phenylcarboxyamide,Benzoylamide	PARP , Endogenous Metabolite
	Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.		PARP , Endogenous Metabolite
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T6220	Nicotinamide riboside chloride		Sirtuin , Endogenous Metabolite
	Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.		Sirtuin , Endogenous Metabolite
T10990	Dehydrocorydaline chloride	13-Methylpalmatine chloride	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
TN2883	3',4'-Dimethoxyflavone		Others , PARP
	3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.		Others , PARP
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T1152	Albendazole	SKF-62979	HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
	Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T8296	5,7,4'-Trimethoxyflavone	4',5,7-Trimethoxyflavone	Apoptosis , PARP , Caspase
	5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.		Apoptosis , PARP , Caspase
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
TN1880	Lucidenic acid B	Lucidenicacid B	Apoptosis , Caspase
	Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mito...		Apoptosis , Caspase
T9113	Myristicin	Myristicine	IL Receptor , Anti-infection , BCL , P450 , PARP , 5-HT Receptor , Caspase , GABA Receptor , NO Synthase
	Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ...
T3S1471	Cucurbitacin IIA	Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis , Survivin
	1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...		Apoptosis , Survivin
T6S2391	L-Chicoric Acid	(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid	Others , HIV Protease
	L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ...		Others , HIV Protease
T4973	Paraxanthine	1,7-DIMETHYLXANTHINE	Endogenous Metabolite
	Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...		Endogenous Metabolite
T6942	Picolinamide	2-Pyridinecarboxamide,2-Carbamoylpyridine,2-Picolinamide,Picolinoylamide	PARP
	Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.		PARP
T24638	Picrasidine M
	Picrasidine M is a PARP-1 inhibitor.
TN1139	Dehydrocavidine	Dehydrocorydaline	BCL , PARP
	Dehydrocavidine (Dehydrocorydaline) has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.		BCL , PARP
T73403	Aviculin
	Aviculin, a lignan glycoside, exhibits significant anticancer properties, particularly in inhibiting the metabolic activity of MCF-7 cells to below 50%, with an IC 50 value of 75.47 μM. It promotes apoptosis in breast ca...
TN4046	Excisanin A		MMP , FAK , PARP , GSK-3 , NF-κB , Wnt/beta-catenin , Akt , Caspase , PI3K , Prostaglandin Receptor , JNK
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatm...

Natural Products

Fucosterol

T8184

Synonym:

Target: PARP, Endogenous Metabolite, PPAR

Nicotinamide riboside

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

Target: PARP, Endogenous Metabolite

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Benzamide

T6780

Synonym: Amid kyseliny benzoove,Phenylcarboxyamide,Benzoylamide

Target: PARP, Endogenous Metabolite

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Nicotinamide riboside chloride

T6220

Synonym:

Target: Sirtuin, Endogenous Metabolite

Dehydrocorydaline chloride

T10990

Synonym: 13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

3',4'-Dimethoxyflavone

TN2883

Synonym:

Target: Others, PARP

5,7-Dihydroxychromone

T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Albendazole

T1152

Synonym: SKF-62979

Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite

5,7,4'-Trimethoxyflavone

T8296

Synonym: 4',5,7-Trimethoxyflavone

Target: Apoptosis, PARP, Caspase

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Lucidenic acid B

TN1880

Synonym: Lucidenicacid B

Target: Apoptosis, Caspase

Myristicin

T9113

Synonym: Myristicine

Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase

Cucurbitacin IIA

T3S1471

Synonym: Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

L-Chicoric Acid

T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid

Target: Others, HIV Protease

Paraxanthine

T4973

Synonym: 1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Picolinamide

T6942

Synonym: 2-Pyridinecarboxamide,2-Carbamoylpyridine,2-Picolinamide,Picolinoylamide

Synonym: Dehydrocorydaline

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01188	PARP Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...
TMPY-02465	PARP Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...
TMPY-02421	PARP3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp...
TMPH-01879	PARP11 Protein, Human, Recombinant (His)	Human	E. coli
	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis.
TMPH-01942	PARP14 Protein, Human, Recombinant (His & Myc)	Human	HEK293
	PARP14 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01944	PARP9 Protein, Human, Recombinant (His & Myc)	Human	HEK293
	PARP9 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01945	TIPARP Protein, Human, Recombinant (His)	Human	Baculovirus
	TIPARP Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPH-01881	PARP2 Protein, Human, Recombinant (GST & His)	Human	Baculovirus
	PARP2 Protein, Human, Recombinant (GST & His) is expressed in Baculovirus with N-terminal GST tag and C-terminal 6xHis tag. The predicted molecular weight is 92.8 kDa. Accession number: Q9UGN5
TMPH-01880	PARP2 Protein, Human, Recombinant (His)	Human	E. coli
	Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is t...
TMPH-01943	PARP4 Protein, Human, Recombinant (His)	Human	E. coli
	PARP4 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01882	PARP9 Protein, Human, Recombinant (His)	Human	E. coli
	ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase ...
TMPH-01941	PARP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	PARP12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01056	Caspase-3 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activ...
TMPY-02831	Caspase-7 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are tw...

PARP Protein, Human, Recombinant (His)

TMPY-01188

Species: Human

Expression System: Baculovirus-Insect Cells

PARP Protein, Mouse, Recombinant (His)

TMPY-02465

Species: Mouse

Expression System: Baculovirus-Insect Cells

PARP3 Protein, Human, Recombinant (His & GST)

TMPY-02421

Species: Human

Expression System: Baculovirus-Insect Cells

PARP11 Protein, Human, Recombinant (His)

TMPH-01879

Species: Human

Expression System: E. coli

PARP14 Protein, Human, Recombinant (His & Myc)

TMPH-01942

Species: Human

Expression System: HEK293

PARP9 Protein, Human, Recombinant (His & Myc)

TMPH-01944

Species: Human

Expression System: HEK293

TIPARP Protein, Human, Recombinant (His)

TMPH-01945

Species: Human

Expression System: Baculovirus

PARP2 Protein, Human, Recombinant (GST & His)

TMPH-01881

Species: Human

Expression System: Baculovirus

PARP2 Protein, Human, Recombinant (His)

TMPH-01880

Species: Human

Expression System: E. coli

PARP4 Protein, Human, Recombinant (His)

TMPH-01943

Species: Human

Expression System: E. coli

PARP9 Protein, Human, Recombinant (His)

TMPH-01882

Species: Human

Expression System: E. coli

PARP12 Protein, Human, Recombinant (His & Myc)

TMPH-01941

Species: Human

Expression System: E. coli

Caspase-3 Protein, Human, Recombinant (His)

TMPH-01056

Species: Human

Expression System: E. coli

Caspase-7 Protein, Human, Recombinant (His)

TMPY-02831

Species: Human

Expression System: E. coli

Cat No.	Product Name
L3400	Clinical Compound Library	3480 compounds
	A unique collection of 3480 compounds in clinical trial phases for high throughput screening (HTS) and high content screening (HCS);
L2191	Anti-Breast Cancer Compound Library	1965 compounds
	A unique collection of 1965 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study；

Libraries

Clinical Compound Library

L3400

Compounds: 3480

Anti-Breast Cancer Compound Library

L2191

Compounds: 1965