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Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.
Cat. No. Product name CAS No. Purity Chemical Structure
T13473L αvβ1 integrin-IN-1 TFA (1689540-62-2 free base) T13473L 98%
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
T6657 SB273005 205678-31-5 98%
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
T14573 Bimosiamose disodium 187269-60-9 98%
Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM...
T9914 Vedolizumab 943609-66-3 98%
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.
TP2148 LXW7 TFA (1313004-77-1 free base) TP2148 98%
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3...
T13478 β-glycosidase-IN-1 176485-27-1 98%
β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
T14574 Bimosiamose 187269-40-5 98%
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-...
T6806 Cilengitide TFA 199807-35-7 98%
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectiv...
T8726 Cyclo(RGDyK) 217099-14-4 98%
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
TQ0291 Firategrast 402567-16-2 98%
Firategrast is an orally bioavailable antagonist of α4β1/α4β7 integrin.
T14558 BI-1950 1159724-42-1 98%
BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function an...
T16100 Balamapimod 863029-99-6 98%
Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
TP1879L1 P11 acetate TP1879L1 98%
P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).
T60101 PLN-1474 2408065-32-5 98%
PLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)
T13147 ICAM-1-IN-1 251994-14-6 98%
ICAM-1-IN-1 is a potent and selective E-selectin and ICAM-1 inhibitor(IC50 of 7 and 5 nM, respectively).
T21868 BIO-1211 187735-94-0 98%
BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
T29089 Valategrast hydrochloride 828271-96-1 98%
Valategrast hydrochloride, a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.
T12177 Natalizumab 189261-10-7
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
TP1474 LXW7 1313004-77-1 100%
LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (EC...
TP1330 Cyclo(RADfK) 756500-23-9 100%
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a neg...
αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
T13473L
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
SB273005
T6657
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Bimosiamose disodium
T14573
Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM...
Vedolizumab
T9914
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.
LXW7 TFA (1313004-77-1 free base)
TP2148
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3...
β-glycosidase-IN-1
T13478
β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
Bimosiamose
T14574
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-...
Cilengitide TFA
T6806
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectiv...
Cyclo(RGDyK)
T8726
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Firategrast
TQ0291
Firategrast is an orally bioavailable antagonist of α4β1/α4β7 integrin.
BI-1950
T14558
BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function an...
Balamapimod
T16100
Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
P11 acetate
TP1879L1
P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).
PLN-1474
T60101
PLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)
ICAM-1-IN-1
T13147
ICAM-1-IN-1 is a potent and selective E-selectin and ICAM-1 inhibitor(IC50 of 7 and 5 nM, respectively).
BIO-1211
T21868
BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
Valategrast hydrochloride
T29089
Valategrast hydrochloride, a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.
Natalizumab
T12177
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
LXW7
TP1474
LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (EC...
Cyclo(RADfK)
TP1330
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a neg...
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