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Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.
Cat No. product name
TN1244 3'-Demethylnobiletin 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
TP1474 LXW7 LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (EC...
T14574 Bimosiamose Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-...
T9914 Vedolizumab Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
T3881 Vaccarin Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
T2494 Cilengitide Cilengitide is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.
T10397 ATN-161 trifluoroacetate salt ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases in a murine model.
TP1459L Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base) Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.
TP2384L Hexapeptide-10 Acetate Hexapeptide-10 Acetate is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin r...
T16100 Balamapimod Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
T5485 OSU-T315 OSU-T315 (1,5-regioisomer) is a ILK inhibitor.
T3529 Bestatin hydrochloride Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
T14558 BI-1950 BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function an...
TP1290 GRGDSP acetate(91037-75-1 free base) GRGDSP acetate is a synthetic linear RGD peptide and is an integrin inhibitor.
T8523 ILK-IN-3 ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.
TP1204 IRGD peptide iRGD peptide is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phage...
T3862 Irigenin Irigenin has antifungal activity.
T7570 RGD peptide (GRGDNP) RGD peptide GRGDNP(2TFA) is a integrin-ligand interactions inhibitor.
T16695 Pyrintegrin Pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells' survival. Pyrintegrin can be used as a podocyte-protective agent. Pyrintegrin enhances ...
T4435 E7820 E7820 is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
T5310 TR-14035 TR-14035 is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).
T4613 Arg-Gly-Asp TFA (99896-85-2(free base)) RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrin...
T3404 Cucurbitacin B Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-reg...
T10366L Arg-Gly-Asp-Ser acetate Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bin...
T21868 BIO-1211 BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
T6813 Cyclo(RGDyK) trifluoroacetate Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
T13147 ICAM-1-IN-1 ICAM-1-IN-1 is a potent and selective E-selectin and ICAM-1 inhibitor(IC50 of 7 and 5 nM, respectively).
TP1879L1 P11 acetate P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).
T12783 RWJ 50271 RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 c...
T5488 ILK-IN-2 OSU-T315 is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
TQ0291 Firategrast Firategrast is an orally bioavailable antagonist of α4β1/α4β7 integrin.
T21781 A-286982 A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-...
TQ0250 CWHM-12 CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).
T6966 RGD RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
T6657 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
T13478 β-glycosidase-IN-1 β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
TP1330 Cyclo(RADfK) Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a neg...
T6806 Cilengitide TFA Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectiv...
T3977 Lifitegrast Lifitegrast is a lymphocyte, function-associated antigen-1 antagonist.
T6812 Cyclo(-RGDfK) Cyclo (-RGDfK) is an effective and specific αvβ3 integrin inhibitor.
T14573 Bimosiamose disodium Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM...
TP1484L α2β1 Integrin Ligand Peptide acetate α2β1 Integrin Ligand Peptide acetate is a potential antagonist of α2β1 integrin receptor. α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor ...
T2254 A-205804 A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.
T3638 Leukadherin-1 Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
T4259 GLPG0187 GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).
T6812L Cyclo(-RGDfK) TFA Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).
TP2148 LXW7 TFA (1313004-77-1 free base) LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3...
T13473L αvβ1 integrin-IN-1 TFA (1689540-62-2 free base) αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
T2537 Tirofiban hydrochloride monohydrate Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
T8726 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
3'-Demethylnobiletin
TN1244
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
LXW7
TP1474
LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (...
Bimosiamose
T14574
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for...
Vedolizumab
T9914
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
Vaccarin
T3881
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
Cilengitide
T2494
Cilengitide is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.
ATN-161 trifluoroacetate salt
T10397
ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases in a murine model.
Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)
TP1459L
Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.
Hexapeptide-10 Acetate
TP2384L
Hexapeptide-10 Acetate is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin ...
Balamapimod
T16100
Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
OSU-T315
T5485
OSU-T315 (1,5-regioisomer) is a ILK inhibitor.
Bestatin hydrochloride
T3529
Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
BI-1950
T14558
BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function an...
GRGDSP acetate(91037-75-1 free base)
TP1290
GRGDSP acetate is a synthetic linear RGD peptide and is an integrin inhibitor.
ILK-IN-3
T8523
ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.
iRGD peptide
TP1204
iRGD peptide is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phage...
Irigenin
T3862
Irigenin has antifungal activity.
RGD peptide (GRGDNP)
T7570
RGD peptide GRGDNP(2TFA) is a integrin-ligand interactions inhibitor.
Pyrintegrin
T16695
Pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells' survival. Pyrintegrin can be used as a podocyte-protective agent. Pyrintegrin enhances...
E7820
T4435
E7820 is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
TR-14035
T5310
TR-14035 is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).
Arg-Gly-Asp TFA (99896-85-2(free base))
T4613
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integri...
Cucurbitacin B
T3404
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-reg...
Arg-Gly-Asp-Ser acetate
T10366L
Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bin...
BIO-1211
T21868
BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
Cyclo(RGDyK) trifluoroacetate
T6813
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
ICAM-1-IN-1
T13147
ICAM-1-IN-1 is a potent and selective E-selectin and ICAM-1 inhibitor(IC50 of 7 and 5 nM, respectively).
P11 acetate
TP1879L1
P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).
RWJ 50271
T12783
RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 ...
ILK-IN-2
T5488
OSU-T315 is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
Firategrast
TQ0291
Firategrast is an orally bioavailable antagonist of α4β1/α4β7 integrin.
A-286982
T21781
A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-...
CWHM-12
TQ0250
CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).
RGD
T6966
RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
SB273005
T6657
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
β-glycosidase-IN-1
T13478
β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
Cyclo(RADfK)
TP1330
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a n...
Cilengitide TFA
T6806
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold sele...
Lifitegrast
T3977
Lifitegrast is a lymphocyte, function-associated antigen-1 antagonist.
Cyclo(-RGDfK)
T6812
Cyclo (-RGDfK) is an effective and specific αvβ3 integrin inhibitor.
Bimosiamose disodium
T14573
α2β1 Integrin Ligand Peptide acetate
TP1484L
α2β1 Integrin Ligand Peptide acetate is a potential antagonist of α2β1 integrin receptor. α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin r...
A-205804
T2254
A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.
Leukadherin-1
T3638
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendot...
GLPG0187
T4259
GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).
Cyclo(-RGDfK) TFA
T6812L
Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).
LXW7 TFA (1313004-77-1 free base)
TP2148
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to α...
αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
T13473L
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
Tirofiban hydrochloride monohydrate
T2537
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
Cyclo(RGDyK)
T8726
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
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