Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.

Cat. No.	Product name	CAS No.	Purity
T68078	Gantofiban	183547-57-1	98%
T68078	Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.
TQ0291	Firategrast	402567-16-2	98%
TQ0291	Firategrast is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous system (CNS)...
T13473	αvβ1 integrin-IN-1	1689540-62-2	98%
T13473	αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.
T41151L	K34c hydrochloride		98%
T41151L	K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.
T13473L	αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)	T13473L	98%
T13473L	αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
T8726	Cyclo(RGDyK)	217099-14-4	98%
T8726	Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
TP2148	LXW7 TFA (1313004-77-1 free base)	TP2148	98%
TP2148	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3...
T14558	BI-1950	1159724-42-1	98%
T14558	BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function an...
T9914	Vedolizumab	943609-66-3	98%
T9914	Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.
T13478	β-glycosidase-IN-1	176485-27-1	98%
T13478	β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
T29089	Valategrast hydrochloride	828271-96-1	98%
T29089	Valategrast hydrochloride, a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.
T16100	Balamapimod	863029-99-6	98%
T16100	Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
T6806	Cilengitide TFA	199807-35-7	98%
T6806	Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectiv...
T14573	Bimosiamose disodium	187269-60-9	98%
T14573	Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM...
T6657	SB273005	205678-31-5	98%
T6657	SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
T14574	Bimosiamose	187269-40-5	98%
T14574	Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-...
T3881	Vaccarin	53452-16-7	98%
T3881	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
T8523	ILK-IN-3	6975-75-3	98%
T8523	ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.
T6182	Tirofiban	144494-65-5	98%
T6182	Tirofiban (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
TN1244	3'-Demethylnobiletin	112448-39-2	98%
TN1244	3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...