tubulin β

Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).

Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic.

Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

SKLB050 is derived from the natural chalcone small molecule millepachine (MIL), which is extracted from the plant [Millettia pachycarpa]. SKLB050 exhibits potential antitumor activity both in vitro and in vivo. Biochemical and cellular assays indicate that SKLB050 binds directly and irreversibly to β-tubulin.