analysis

CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R.

Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.

C15AlkOPP Tetrabutylamine salt (1:2) is an FPP analogue, bearing an alkyne group to allow for post-prenylation protein labeling. C15AlkOPP Tetrabutylamine salt (1:2) can be used for Prenylomic analysis

Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets.

D-(-)-Arabinose is a reducing sugar useful as a substrate in analysis of arabinose isomerases and synthesis of D-erythroascorbic acid in yeast. It shows strong growth inhibition against the Caenorhabditis elegans with an IC50 of 7.5 mM.

Salicylaldoxime is a chelating agent sometimes used in the analysis of samples containing transition metal ions, with which it often forms brightly colored coordination complexes.

1-Methoxy-3-methylbenzene is a potential acetylcholinesterase inhibitor identified through QSAR (quantitative structure-activity relationship) analysis, and is widely used in biochemical experiments and drug synthesis research.

L-Aspartic acid (Standard) is a reference standard for research and analysis in studies involving L-Aspartic acid. L-Aspartic acid (Aspatofort) is a widely occurring amino acid in both plants and animals, and serves as a prodrug for colon-specific drug delivery.

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induces apoptosis in A549 cells independently of cell cycle arrest, mediated by JNK and p38 MAPK signaling pathways. These pathways are activated due to oxidative DNA damage from increased ROS generation in MNQ-treated A549 cells.

2′-Deoxyadenosine 5′-monophosphate disodium (a nucleic acid AMP derivative) is a deoxyribonucleotide in DNA, used for studying adenosine-based interactions in DNA synthesis and damage analysis.

5-Methoxysalicylic acid (5-MeOSA), a natural product, serves as an effective matrix for oligonucleotide analysis in MALDI MS when used alongside spermine.

PIPES (1,4-Piperazinediethanesulfonic acid) disodium is an amphoteric ion biological buffer agent commonly used to prepare buffers with a pH of 6.1 to 7.5, often employed in cell culture media, protein analysis, and electrophoresis experiments.

NDSB-211 is a surfactant with small hydrophobic ends and mildly solubilizes proteins for protein extraction and analysis.

1-Thioglycerol (alpha-Thioglycerol) is an antioxidant thioglycerol that scavenges free radicals and reduces oxidative stress as a media component, and is used as a matrix in fast atom bombardment mass spectrometry (FAB-MS) and liquid secondary ion mass spectrometry (LSIMS).

N-Ethyl-o-toluidine is a drug with genotoxicity and anticancer potential, exhibiting >70% growth inhibition against yeast strains with specific genetic alterations. It can also serve as an intermediate in dye synthesis.

N-heptadecane is a saturated hydrocarbon compound commonly used as a standard substance in chemical analysis and can be used in biochemical experiments and drug synthesis research.

Silver chloride can be used as a buffer in electrodes or spectroscopic analysis. Silver chloride exhibits inhibitory activity against various bacteria and demonstrates antitumour activity against Ewing sarcoma when formulated as nanoparticles (AgCl-NPs).

6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) is a chromogenic substrate for β-glucuronidase and can be utilized in the histochemical analysis of β-glucuronidase activity.

NSC 404988 is a benzamide-based bioactive compound used in the synthesis of compounds and the preparation of drugs, and has also been used in the study of drug metabolism and the analysis of metabolites in biological systems.

CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the

D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.

Heptasaccharide Glc4Xyl3 is a covalent inhibitor of endo-xyloglucanases. It used for the identification and analysis of diverse xyloglucan-active enzymes in nature.

(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, shows promise as a therapeutic candidate for xerostomia in Sjogren's syndrome. It exhibits a broad pharmacological profile across various systems in animal models including mice, rats, guinea pigs, rabbits, and dogs. Metabolism studies using rat and dog liver microsomes reveal rapid absorption with peak plasma concentrations (Cmax) within one hour post-oral administration and a half-life (t1 2) between 0.4 to 1.1 hours. Bioavailability is 50% in rats and 30% in dogs. Metabolic analysis shows species-specific differences: rats produce S- and N-oxidized metabolites, while dogs produce only N-oxidized metabolites. Sex-based pharmacokinetic differences were noted in rats but not in dogs. In vitro studies indicate cytochrome P450 (CYP) and flavin-containing monooxygenase (FMO) involvement in the sulfoxidation and N-oxidation of SNI-2011, with CYP2D and CYP3A mainly responsible for sulfoxidation in rat liver microsomes.

18:0 LYSO-PE is a compound that induces an increase in [Ca2+]i and can be used as a phospholipid (PL) standard for lipid analysis by electrospray mass spectrometry (ESI-MS) MS.