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Search Results for " ep4 "

20

Compounds

Cat No. Product Name Synonyms Targets
T11211 EP4 receptor antagonist 1 Prostaglandin Receptor
EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both human and mouse EP4 receptors with IC50 values of 6.1 nM and...
T77699 EP4-IN-1 Prostaglandin Receptor
EP4-IN-1 is a potent prostaglandin EP4 receptor inhibitor with potential anti-tumor, anti-inflammatory and analgesic activities for the study of immune and tumor diseases.
T38595 EP4 receptor antagonist 3 EP4 receptor antagonist 3
EP4 receptor antagonist 3 is a highly potent and specific inhibitor of the EP4 receptor. It is intended for research purposes in studying EP4 receptor-mediated diseases such as acute and chronic pain, osteoarthritis, rhe...
T83779 EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A...
T60840 EP4 receptor antagonist 4
EP4 receptor antagonist 4 is an agonist of EP4 receptor (human pEC 50 = 6.3) [1].
T63100 EP4 receptor antagonist 2
EP4 receptor antagonist 2 (compound 2-13) is a potent agonist of the EP4 receptor (IC50: 7.8 nM) and has antitumour effects.
T9622 MF-766 Prostaglandin Receptor
MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It...
T5841 Travoprost Flu-Ipr,Fluprostenol isopropyl ester,AL6221 Prostaglandin Receptor
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
T1626 Prostaglandin E1 PGE1,Alprostadil Endogenous Metabolite , Prostaglandin Receptor
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, in...
T37701 Pep4c pep4c
pep4c can be used for related research in the field of life sciences. Its product number is T37701 and CAS number is 243843-43-8.
TQ0292 Grapiprant AAT-007,RQ-00000007,CJ-023423 Prostaglandin Receptor
Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).
TQ0025 E7046 Prostaglandin Receptor
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
T62525 TP-16 Prostaglandin Receptor
TP-16 is a novel potent and selective EP4 antagonist that blocks the function of IMCs and enhances cytotoxic T cell-mediated tumor elimination in vivo.
TQ0290 ONO-AE3-208 AE 3-208 Prostaglandin Receptor
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
T14975 CJ-42794 CJ-042794 Others
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-...
T1978 GW627368 GW 627368X Prostaglandin Receptor
GW627368 (GW 627368X)X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T15681 L-161982 Prostaglandin Receptor
L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.
T8993L BGC-20-1531 hydrochloride(1186532-61-5 free base) BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride Prostaglandin Receptor
BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) is a EP4 antagonist for the treatment of acute migraine.
T5482 TG4-155 Prostaglandin Receptor
TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels
T63349 Treprostinil diethanolamine UT-15C Prostaglandin Receptor
Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FPKi, respectively. Treprostinil diethanolamine i...
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