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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11211 | EP4 receptor antagonist 1 | Prostaglandin Receptor | |
EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both human and mouse EP4 receptors with IC50 values of 6.1 nM and... | |||
T77699 | EP4-IN-1 | Prostaglandin Receptor | |
EP4-IN-1 is a potent prostaglandin EP4 receptor inhibitor with potential anti-tumor, anti-inflammatory and analgesic activities for the study of immune and tumor diseases. | |||
T38595 | EP4 receptor antagonist 3 | EP4 receptor antagonist 3 | |
EP4 receptor antagonist 3 is a highly potent and specific inhibitor of the EP4 receptor. It is intended for research purposes in studying EP4 receptor-mediated diseases such as acute and chronic pain, osteoarthritis, rhe... | |||
T83779 | EP4 Antagonist 14 | Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 | |
EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A... | |||
T60840 | EP4 receptor antagonist 4 | ||
EP4 receptor antagonist 4 is an agonist of EP4 receptor (human pEC 50 = 6.3) [1]. | |||
T63100 | EP4 receptor antagonist 2 | ||
EP4 receptor antagonist 2 (compound 2-13) is a potent agonist of the EP4 receptor (IC50: 7.8 nM) and has antitumour effects. | |||
T9622 | MF-766 | Prostaglandin Receptor | |
MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It... | |||
T5841 | Travoprost | Flu-Ipr,Fluprostenol isopropyl ester,AL6221 | Prostaglandin Receptor |
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist. | |||
T1626 | Prostaglandin E1 | PGE1,Alprostadil | Endogenous Metabolite , Prostaglandin Receptor |
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, in... | |||
T37701 | Pep4c | pep4c | |
pep4c can be used for related research in the field of life sciences. Its product number is T37701 and CAS number is 243843-43-8. | |||
TQ0292 | Grapiprant | AAT-007,RQ-00000007,CJ-023423 | Prostaglandin Receptor |
Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). | |||
TQ0025 | E7046 | Prostaglandin Receptor | |
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities. | |||
T62525 | TP-16 | Prostaglandin Receptor | |
TP-16 is a novel potent and selective EP4 antagonist that blocks the function of IMCs and enhances cytotoxic T cell-mediated tumor elimination in vivo. | |||
TQ0290 | ONO-AE3-208 | AE 3-208 | Prostaglandin Receptor |
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. | |||
T14975 | CJ-42794 | CJ-042794 | Others |
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... | |||
T1978 | GW627368 | GW 627368X | Prostaglandin Receptor |
GW627368 (GW 627368X)X is a novel, potent and selective antagonist of prostanoid EP4 receptor. | |||
T15681 | L-161982 | Prostaglandin Receptor | |
L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice. | |||
T8993L | BGC-20-1531 hydrochloride(1186532-61-5 free base) | BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride | Prostaglandin Receptor |
BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) is a EP4 antagonist for the treatment of acute migraine. | |||
T5482 | TG4-155 | Prostaglandin Receptor | |
TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels | |||
T63349 | Treprostinil diethanolamine | UT-15C | Prostaglandin Receptor |
Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FPKi, respectively. Treprostinil diethanolamine i... |