T13627 |
CP-10
|
2366268-80-4
|
98%
|
|
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
|
T11309 |
FMF-04-159-2
|
2364489-81-4
|
98%
|
|
FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
|
T1947 |
BS-181
|
1092443-52-1
|
98%
|
|
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
|
TN4394 |
Kobophenol A
|
124027-58-3
|
98%
|
|
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
|
T10735 |
CDK4/6/1 Inhibitor
|
2099128-41-1
|
98%
|
|
CDK4/6/1 Inhibitor is a CDK4/6 inhibitor (IC50s: 3 and 1 nM).
|
T13058 |
T025
|
2407433-00-3
|
98%
|
|
T025 is a highly potent and orally available inhibitor of Cdc2-like kinase (CLK)(Kds of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, respectively...
|
T15730 |
Ribociclib hydrochloride
|
1211443-80-9
|
98%
|
|
Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
|
T10382 |
AS2863619 free base
|
2241300-50-3
|
98%
|
|
AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 ...
|
T10741 |
CDK9-IN-1
|
1415559-43-1
|
98%
|
|
CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
|
T2653 |
SB1317
|
1204918-72-8
|
98%
|
|
SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
|
TN3802 |
Dehydrodiconiferyl alcohol
|
4263-87-0
|
98%
|
|
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
|
TN3247 |
7-O-Prenylscopoletin
|
13544-37-1
|
98%
|
|
7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
|
T10724 |
Cdc7-IN-1
|
1402055-25-7
|
98%
|
|
Cdc7-IN-1 is a highly selective and ATP competitive inhibitor of Cdc7 kinase (IC50: 0.6 nM at 1 mM ATP). It potently inhibits Cdc7 activity in cancer cells and e...
|
T14136 |
AG-024322
|
837364-57-5
|
98%
|
|
AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
|
T10546 |
Bio-THZ1
|
1604811-14-4
|
98%
|
|
bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).
|
T13696 |
FN-1501-propionic acid
|
2408642-48-6
|
98%
|
|
FN-1501-propionic acid and a CRBN ligand have been used to design PROTAC CDK2/9 degrader . FN-1501-propionic acid is a CDK2/9 ligand for PROTAC.
|
T10220 |
Abemaciclib metabolite M2
|
1231930-57-6
|
98%
|
|
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity.
|
T13370 |
YM-46303
|
171722-81-9
|
98%
|
|
YM-46303 is an antagonist of mAChR
|
T11345 |
Lerociclib
|
1628256-23-4
|
98%
|
|
Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
|
T10739 |
CDK8/19-IN-1
|
1818427-07-4
|
98%
|
|
CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
|