T17305 |
CDK8-IN-4
|
1613638-82-6
|
98%
|
|
CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
|
T10735 |
CDK4/6/1 Inhibitor
|
2099128-41-1
|
98%
|
|
CDK4/6/1 Inhibitor is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone re...
|
T14136 |
AG-024322
|
837364-57-5
|
98%
|
|
AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
|
TN3719 |
Cristacarpin
|
74515-47-2
|
98%
|
|
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
|
T10743 |
CDK9-IN-11
|
T10743
|
98%
|
|
CDK9-IN-11 is a potent CDK9 inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 [1].
|
T15730 |
Ribociclib hydrochloride
|
1211443-80-9
|
98%
|
|
Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
|
T10741 |
CDK9-IN-1
|
1415559-43-1
|
98%
|
|
CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
|
TN3673 |
Clausine Z
|
866111-14-0
|
98%
|
|
Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
|
TN4263 |
Isoangustone A
|
129280-34-8
|
98%
|
|
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
|
T2653 |
SB1317
|
1204918-72-8
|
98%
|
|
SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
|
T13202L |
Trilaciclib
|
1374743-00-6
|
98%
|
|
Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
|
T10739 |
CDK8/19-IN-1
|
1818427-07-4
|
98%
|
|
CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
|
T13425 |
(1S,3R,5R)-PIM447 dihydrochloride
|
T13425
|
98%
|
|
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
|
T13627 |
CP-10
|
2366268-80-4
|
98%
|
|
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
|
T25125 |
AZA197
|
1249398-09-1
|
98%
|
|
AZA197 is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downre...
|
T13309 |
Voruciclib hydrochloride
|
1000023-05-1
|
98%
|
|
Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
|
T12617 |
(R)-CR8 trihydrochloride
|
1786438-30-9
|
98%
|
|
(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
|
T11656 |
Indoramin D5
|
57165-41-0
|
98%
|
|
Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin.
|
T64373 |
CDK1-IN-2
|
|
98%
|
|
CDK1-IN-2 is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.
|
T12642L |
Simurosertib
|
1330782-76-7
|
98%
|
|
Simurosertib is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).
|