CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T2653	SB1317	1204918-72-8	100%
T2653	SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
T1947	BS-181	1092443-52-1
T1947	BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
TN1663	Ganoderic acid DM	173075-45-1	98%
TN1663	Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
T17305	CDK8-IN-4	1613638-82-6	98%
T17305	CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
TN4394	Kobophenol A	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T12617	(R)-CR8 trihydrochloride	1786438-30-9	98%
T12617	(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
T5438	PROTAC CDK9 Degrader-1	2118356-96-8	98%
T5438	PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
T10737	CDK4/6-IN-3	2366237-37-6	98%
T10737	CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
T16038	Men 10376	135306-85-3	98%
T16038	Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
TN4263	Isoangustone A	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T11309	FMF-04-159-2	2364489-81-4	98%
T11309	FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
T10739	CDK8/19-IN-1	1818427-07-4	98%
T10739	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
T15730	Ribociclib hydrochloride	1211443-80-9	98%
T15730	Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
T13425	(1S,3R,5R)-PIM447 dihydrochloride	T13425	98%
T13425	(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
T11656	Indoramin D5	57165-41-0	98%
T11656	Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin.
T10172	5-Iodo-indirubin-3'-monoxime	331467-03-9	98%
T10172	5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s:...
T13309	Voruciclib hydrochloride	1000023-05-1	98%
T13309	Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
TMA1743	Ergosterol peroxide	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN3802	Dehydrodiconiferyl alcohol	4263-87-0	98%
TN3802	Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
T6139	A-674563	552325-73-2	98%
T6139	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.