T2653 |
SB1317
|
1204918-72-8
|
100%
|
|
SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
|
T1947 |
BS-181
|
1092443-52-1
|
|
|
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
|
TN1663 |
Ganoderic acid DM
|
173075-45-1
|
98%
|
|
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
|
T17305 |
CDK8-IN-4
|
1613638-82-6
|
98%
|
|
CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
|
TN4394 |
Kobophenol A
|
124027-58-3
|
98%
|
|
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
|
T12617 |
(R)-CR8 trihydrochloride
|
1786438-30-9
|
98%
|
|
(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
|
T5438 |
PROTAC CDK9 Degrader-1
|
2118356-96-8
|
98%
|
|
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
|
T10737 |
CDK4/6-IN-3
|
2366237-37-6
|
98%
|
|
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
|
T16038 |
Men 10376
|
135306-85-3
|
98%
|
|
Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
|
TN4263 |
Isoangustone A
|
129280-34-8
|
98%
|
|
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
|
T11309 |
FMF-04-159-2
|
2364489-81-4
|
98%
|
|
FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
|
T10739 |
CDK8/19-IN-1
|
1818427-07-4
|
98%
|
|
CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
|
T15730 |
Ribociclib hydrochloride
|
1211443-80-9
|
98%
|
|
Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
|
T13425 |
(1S,3R,5R)-PIM447 dihydrochloride
|
T13425
|
98%
|
|
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
|
T11656 |
Indoramin D5
|
57165-41-0
|
98%
|
|
Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin.
|
T10172 |
5-Iodo-indirubin-3'-monoxime
|
331467-03-9
|
98%
|
|
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s:...
|
T13309 |
Voruciclib hydrochloride
|
1000023-05-1
|
98%
|
|
Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
|
TMA1743 |
Ergosterol peroxide
|
2061-64-5
|
98%
|
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
|
TN3802 |
Dehydrodiconiferyl alcohol
|
4263-87-0
|
98%
|
|
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
|
T6139 |
A-674563
|
552325-73-2
|
98%
|
|
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
|