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cAMP
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cholecystokinin
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EBI2/GPR183
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GPCR19
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advanced glycation end products
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Porcupine
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Stemness kinase
TGF-beta/Smad
Wnt/beta-catenin
YAP
ACK
ALK
Bcr-Abl
BTK
c-Fms
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FAK
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FLT
Hck
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IGF-1R
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PKA
PYK2
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Src
Syk
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Tie-2
Trk receptor
Tyrosine Kinases
VEGFR
DUB
E1/E2/E3 Enzyme
p97
Proteasome
PROTAC-Linker Conjugates for PAC
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Antibody-Drug Conjugates (ADCs)
ADC Linker
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Tumor
Anti-infective
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Development and reproduction
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Metabolic diseases
Neurological disorders
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Natural Products

Plant
Structure

Alangiaceae
Aquifoliaceae
Cephalotaxaceae
Costaceae
Daphniphyllaceae
Dioscoreaceae
Eucommiaceae
Ginkgoaceae
Hippocastanaceae
Illiciaceae
Lycopodiaceae
Moringaceae
Myricaceae
Myristicaceae
Nelumbonaceae
Nothofagaceae
Nyssaceae
Orobanchaceae
Paeoniaceae
Piperaceae
Podocarpaceae
Pteridaceae
Resedaceae
Sapindaceae
Schisandraceae
Stemonaceae
Theaceae
Other
Alkaloids
Coumarins
Flavonoids
Lignans
Others
Phenols
Phenylpropanoids
Quinones
Saccharides and Glycosides
Steroids
Terpenoids

Recombinant Proteins

CAR-T Therapy Target Proteins
CD Proteins
Complement System
Cytokines and Growth Factors
Enzymes
Fluorescent Proteins
Hormones
Immune Checkpoint Proteins
Others
Receptor Proteins
Viral Proteins

Hematologic Malignancies Target Proteins
Solid Tumors Target Proteins
B Cell CD Proteins
Cell Activation CD Proteins
Cell Adhesion CD Proteins
Cytokine Receptor CD Proteins
Endothelial Cell CD Proteins
Myeloid Cell CD Proteins
NK/Non-lineage Cell CD Proteins
Other CD Proteins
Platelet CD Proteins
T Cell CD Proteins
Cytokines
Epidermal Growth Factor Family, EGFs
Growth Factors
Others
Hydrolases,EC 3
Isomerases,EC 5
Ligases or Synthetases,EC 6
Lyases,EC 4
Oxidoreductases,EC 1
Transferases,EC 2
Translocases,EC 7
Butyrophilins
Co-inhibitory Immune Checkpoint Proteins
Co-stimulatory Immune Checkpoint Proteins
Cell Adhesion Receptors
Cytokines and Growth Factor Receptors
Enzyme-Linked Receptors
Fc Receptors
G Protein-Coupled Receptors, GPCRs
Ion Channel-Linked Receptors
Nuclear Receptors
Receptor Serine/Threonine Kinases
Receptor Tyrosine Kinases
Others
Coronavirus (CoV) Proteins
DENV Proteins
EBOV Proteins
HBV Proteins
HCV Proteins
HIV Proteins
Influenza Proteins
RSV Proteins
Others

Technical Services

Technical Services

Molecular Docking
Virtual Screening
Biomolecular Interaction
Custom Synthesis
AI-driven Ultra High-throughput Virtual Screening

Poly(ADP-ribose) Glycohydrolase (PARG)

PARG (Poly(ADP-ribose) Glycohydrolase) is responsible for the degradation of poly(ADP-ribose) (PAR) synthesised by PARP (Poly(ADP-ribose) Polymerase), thereby maintaining a balanced intracellular level of PAR.PARG has a number of important roles that are required for DNA damage repair, maintenance of replication fork stability, regulation of proliferation and differentiation.

Filter HomeSignaling PathwaysCell Cycle/CheckpointPoly(ADP-ribose) Glycohydrolase (PARG)

PARG-IN-4

T815462988890-20-4

PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity.