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Poly(ADP-ribose) Glycohydrolase (PARG)

PARG (Poly(ADP-ribose) Glycohydrolase) is responsible for the degradation of poly(ADP-ribose) (PAR) synthesised by PARP (Poly(ADP-ribose) Polymerase), thereby maintaining a balanced intracellular level of PAR.PARG has a number of important roles that are required for DNA damage repair, maintenance of replication fork stability, regulation of proliferation and differentiation.

FilterHomeSignaling PathwaysCell Cycle/CheckpointPoly(ADP-ribose) Glycohydrolase (PARG)
PDD00017273
T57001945950-21-9
PDD00017273 is a radiosensitizing PARG) inhibitor with antitumor or activity for the study of epithelial ovaries.
  • $75
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TargetMol | Citations Cited
COH34
T10859906439-72-3
COH34 (1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
  • $66
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TargetMol | Inhibitor Sale
PDD00017272
T393561945950-20-8
PDD00017272 (34f) is a potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), exhibiting an EC50 value of 4.8 nM in biochemical assays and 9.2 nM in cellular POM.
  • $99
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Endo-1,4-β-xylanase
T761799025-57-4
Endo-1,4-β-xylanase (Xylanase), a glycoside hydrolase enzyme that degrades arabinoxylan (AX), is commonly utilized in biochemical research. It specifically hydrolyzes the β-xylosidic bonds linking two d-xylopyranosyl residues in a β-(1,4) configuration [1].
  • $29
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COH34 analog 1
T10858314248-24-3
COH34 analog 1 is a COH34 oxidation analogue that can be used to synthesize active compounds.
  • $30
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TargetMol | Inhibitor Sale
PARG-IN-4
T815462988890-20-4
PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity.
  • $215
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pNP-ADPr
T41083939028-75-8
pNP-ADPr is a colorimetric substrate used in continuous activity assays for Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3), aiding research on poly(ADP-ribose) polymerase (PARP) enzymes.
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PDD00017238
T393651952247-05-0
PDD00017238 demonstrates a robust inhibitory effect on Poly(ADP-ribose) Glycohydrolase (PARG), displaying EC50 values of 40 nM in biochemical assay and 55 nM in cell POM assessment.
  • $78
5 days
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TFMU-ADPr
T745102412923-11-4
TFMU-ADPr serves as a versatile substrate for assessing poly(ADP-ribose) glycohydrolase (PARG) activity, enabling direct measurement of total PAR hydrolase activity through the liberation of a fluorophore. Exhibiting exceptional reactivity, generality, stability, and usability, TFMU-ADPr is an effective tool for evaluating small-molecule inhibitors and investigating the regulation of ADP-ribosyl catabolic enzymes in vitro [1].
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PDD00031705
T123882032096-45-8
PDD00031705 is a benzimidazolone core, cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.
  • $1,230
8-10 weeks
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JA2131
T734796505-99-3
JA2131, a small molecular inhibitor targeting Poly(ADP-ribose) Glycohydrolase (PARG), has an IC50 value of 0.4 μM, modulates DNA damage responses, induces replication fork stalling, and leads to cancer cell death.
  • $1,330
6-8 weeks
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TFMU-ADPr triethylamine
T74511
TFMU-ADPr triethylamine, a versatile substrate for evaluating poly(ADP-ribose) glycohydrolase (PARG) activity, enables direct measurement of total PAR hydrolase activity through the liberation of a fluorophore. With outstanding reactivity, generality, stability, and usability, it serves as an essential tool for the in vitro assessment of small-molecule inhibitors and exploration of the regulation of ADP-ribosyl catabolic enzymes [1].
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Ethacridine
T88097442-16-0
Ethacridine acts as an inhibitor of poly (ADP-ribose) glycohydrolase (PARG) and functions as an activator of transcriptional coactivators. It induces apoptosis in thyroid cancer cells and promotes the differentiation of thyroid follicular cells.
  • $1,520
6-8 weeks
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pNP-ADPr disodium
T78401
pNP-ADPr disodium serves as a colorimetric substrate in the inaugural continuous assays of Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activities. It also facilitates research into poly(ADP-ribose)polymerase (PARP) enzymes [1] [2].
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