cd-10

CD-10 is an orally active inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) that can penetrate the blood-brain barrier. It binds to Keap1 with a KD value of 193 nM. CD-10 exerts significant antioxidant and anti-inflammatory effects by activating the Keap1-Nrf2 pathway, demonstrated by reduced levels of MDA, IL-4, and IL-10, and increased expression of HO-1 protein. In a chronic unpredictable mild stress (CUMS) mouse model, CD-10 effectively alleviates anxiety and depressive behaviors and restores serum neurotransmitter levels by promoting Nrf2 nuclear translocation. CD-10 is applicable for research in depression.

Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.

Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan are used to treat hypertension and heart failure.

Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM and is a component of the heart failure medicine LCZ696.

Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.

Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).

Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).

Rezafungin (SP-3025, Biafungin) is a natural product echinocandin and a 1,3-β-D-glucan synthase inhibitor with broad-spectrum antifungal activity, high tissue penetration, and a long half-life, used for the treatment of candidemia and invasive candidiasis.

Rezafungin acetate (Biafungin acetate) is a echinocandin with antimicrobial activity that inhibits 1,3-β-D-glucan synthase. It can be used for research on invasive fungal diseases in hematopoietic and bone marrow transplant recipients.

Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.

Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.

CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].

Anti-Mouse CD103 Antibody (M290) is a rat-derived IgG2a, κ antibody inhibitor that targets mouse CD103.

Anti-VCAM1/CD106 Antibody is a monoclonal antibody targeting vascular cell adhesion molecule-1 (VCAM1/CD106). It inhibits leukocyte recruitment to inflammatory sites and tumor tissues by blocking the interaction between VCAM1 and integrin VLA-4.

Anti-Human CD103 Antibody (hCD103.01A) is a monoclonal inhibitory antibody against human CD103, which can be used in cancer immunotherapy research.

Carotuximab-MMAE, an ADC, comprises a CD105-targeted antibody linked to Monomethyl auristatin E (MMAE), displaying notable antitumor properties.

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an IgG1, κ inhibitor antibody derived from rats, specifically targeting mouse CD106/VCAM-1.

Anti-LAMP1/CD107a Antibody (SAR-428926 antibody) is a humanized monoclonal antibody targeting Lysosomal-Associated Membrane Protein 1 (LAMP1/CD107a). LAMP1 is typically located on lysosomal membranes but is highly expressed on the surface of various solid tumor cells. Serving as the targeting moiety of the antibody-drug conjugate (ADC) SAR-428926, this antibody specifically binds to surface-expressed LAMP1, mediating the internalization of the ADC and the release of a potent maytansinoid cytotoxic payload. This targeting strategy demonstrates outstanding anti-tumor efficacy in patient-derived xenograft (PDX) models of solid tumors, effectively inhibiting tumor growth.

WRN inhibitor 10 (Compound P24) is an inhibitor of the Werner helicase WRN, with an IC50 of 1.1 nM. It effectively inhibits the proliferation of SW48 cancer cells, with an IC50 of 39 nM. WRN inhibitor 10 exhibits favorable liver microsomal stability and membrane permeability, and demonstrates good pharmacokinetic properties in CD-1 mice.

Cryptolepinone is a quinone reductase (Quinone Reductase) activator, with a CD value (the concentration required to double induction activity) of 0.02 μg/mL, found in Sida acuta. In mouse mammary organ culture assays, 10 μg/mL of Cryptolepinone shows an 83.3% inhibition rate of DMBA-induced preneoplastic lesions. Cryptolepinone is applicable for research in the anticancer field.