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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9497 | Niraparib tosylate monohyrate | PARP | |
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting... | |||
T39695 | ARD-2128 | Androgen Receptor | |
ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protein levels, suppressing AR-regulated gene expression in tumor... | |||
T12266 | Ilginatinib | NS-018 | Tyrosine Kinases , JAK |
Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2. | |||
T5414 | Glumetinib | SCC244 | c-Met/HGFR |
Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM). | |||
T12266L2 | Ilginatinib hydrochloride | NS-018 hydrochloride | Tyrosine Kinases , JAK |
Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2. | |||
T12266L | Ilginatinib maleate | NS-018 maleate | Tyrosine Kinases , JAK |
Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2. | |||
T4488 | GSK-25 | GSK25 | ROCK , S6 Kinase , mTOR |
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). | |||
T3231 | Niraparib | MK-4827 | Apoptosis , Others , PARP |
Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis. | |||
T6714 | URB-597 | KDS-4103,FAAH Inhibitor II | Mitophagy , FAAH , Autophagy |
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets. | |||
T6041 | Oprozomib | PR-047,ONX 0912 | Proteasome , Autophagy |
Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has potential antineoplastic activity. | |||
T2119 | Venetoclax | GDC-0199,ABT 199,ABT-199,ABT199 | BCL , Autophagy |
Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces a... | |||
T17225 | Vercirnon | CCX282-B,GSK-1605786,Traficet-EN | CCR |
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases. | |||
T9146 | Ms48107 | Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- | Others |
MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch... | |||
T3353 | Niraparib hydrochloride | MK-4827 hydrochloride,MK-4827 (hydrochloride) | Apoptosis , Others , PARP |
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of... | |||
T6892 | Niraparib tosylate | MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate | Apoptosis , PARP |
Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. | |||
T26174 | SAK3 | SAK-3,SAK 3 | |
SAK 3 is a potent and orally bioavailable CaV3.1/3.3 activator. | |||
T15198 | Edasalonexent | CAT-1004 | NF-κB |
Edasalonexent is an orally bioavailable inhibitor of NF-κB. | |||
T39573 | GSK251 | PI3K | |
GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode. | |||
T17218 | Varespladib methyl | A-002,LY333013 | Others , Phospholipase |
Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor. | |||
T10300 | AMG2850 | TRP/TRPV Channel | |
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8). |