Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.

  • CHIR-99021
    T2310252917-06-9
    CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in mouse and human embryonic stem cells.
    • $36
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Specnuezhenide
    T380339011-92-2
    Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect to the seeds of wheat and Chinese cabbage.
    • $32
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
  • ICG-001
    T6113780757-88-2
    ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • Echinacoside
    T171682854-37-3
    Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilative ones.
    • $70
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Urea
    T073857-13-6
    Urea (Carbonyldiamide) is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the total urinary solids.
    • $30
    In Stock
    Size
    QTY
  • Bisdemethoxycurcumin
    TL000724939-16-0
    Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].
    • $41
    In Stock
    Size
    QTY
  • HLY78
    T11571854847-61-3In house
    HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.
    • $34
    In Stock
    Size
    QTY
  • Ginkgetin
    T4S2126481-46-9
    1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead
    • $120
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • F7H
    T77692897109-93-2
    F7H is a potent Frizzled receptor FZD7 antagonist with an IC50 value of 1.25 μM.F7H is a potent ligand for the transmembrane structural domain (TMD) of FZD7, with potential antitumor and bacteriostatic activity.
    • $54
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Foxy-5 Ammonium Salt
    TP1565L1
    Foxy-5 Ammonium Salt is a WNT5A agonist, a mimetic peptide of WNT5A, a non-classical member of the Wnt family.Foxy-5 Ammonium Salt triggers cytoplasmic free calcium signaling without affecting β-catenin activation and inhibits migration and invasion of epithelial cancer cells.Foxy-5 Foxy-5 Ammonium Salt effectively reduces the metastatic spread of prostate cancer cells with low WNT5A expression in an in situ mouse model.
    • $97
    In Stock
    Size
    QTY
  • ICG001
    T2237847591-62-2
    ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • PARP1/2/TNKS1/2-IN-1
    T724372243453-32-7In house
    PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis.
    • $70
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TNIK-IN-7
    T777191417795-24-4
    TNIK-IN-7 is a potent and selective Traf2 and Nck interacting kinase (TNIK) inhibitor (IC50: 11 nM) with antitumor activity for studying signaling and proliferation in colorectal cancer cells.
    • $139
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TNKS-2-IN-2
    T777332719726-91-5
    TNKS-2-IN-2 is a novel and potent TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.
    • $195
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TNIK-IN-2
    T95572754265-76-2In house
    TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
    • $148
    In Stock
    Size
    QTY
  • YW2036
    T678662131223-92-0
    YW2036 is an inhibitor of Wnt signaling pathway.
    • $117
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Gossypolone
    T319874547-72-2In house
    Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
    • $195
    In Stock
    Size
    QTY
  • β-catenin modulator IIa-661
    T678841015859-04-7
    β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
    • $50
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Wnt pathway activator 2
    T133451360540-82-4In house
    Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
    • $51
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TNIK-IN-5
    T98102754265-66-0In house
    TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.
    • $129
    In Stock
    Size
    QTY
  • DK419
    T151372102672-22-8In house
    DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
    • $79
    In Stock
    Size
    QTY
  • GSK-3β inhibitor 8
    T355561139875-74-3In house
    GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway and stimulates β-cell proliferation.
    • $110
    35 days
    Size
    QTY
    TargetMol | Inhibitor Sale
  • NRX-103094
    T634272763260-36-0In house
    NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
    • $67
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • FzM1
    T240761680196-54-6In house
    FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
    • $35
    In Stock
    Size
    QTY
  • Miclxin
    T734152494198-61-5In house
    Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60.
    • $96
    In Stock
    Size
    QTY
  • Carboxylesterase-IN-3
    T607882764748-92-5In house
    Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.
    • $98
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • SRI 37892
    T96621030769-75-5In house
    SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
    • $397
    In Stock
    Size
    QTY
  • NRX-103095
    T637302763260-38-2In house
    NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.
    • $215
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • ZW4864 free base
    T96422632259-92-6In house
    ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a K i value of 0.76 μM and an IC 50 value of 0.87 μM [1]. ZW4864 (free base) shows good pharmacokinetic properties.
    • $163
    In Stock
    Size
    QTY
  • TNIK-IN-3
    T95562754265-25-1In house
    TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 μM), Flt1 (IC50 = 0.191 μM), and DRAK1 (IC50 = 0.411 μM). This compound holds potential for carrying out research on colorectal cancer (CRC) [1].
    • $132
    In Stock
    Size
    QTY
  • NRX-252262
    T91822438637-61-5In house
    NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
    • $116
    In Stock
    Size
    QTY
  • NRX-252114
    T635162763260-39-3In house
    NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.
    • $196
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • CCT 031374 hydrobromide
    T216851219184-91-4In house
    CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
    • $68
    In Stock
    Size
    QTY
  • XAV-939
    T1878284028-89-3
    XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription.
    • $48
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • LF3
    T7399664969-54-4
    LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Wnt-C59
    T22421243243-89-1
    Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
    • $33
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • SKL2001
    T6989909089-13-0
    SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • BML-284
    T3144853220-52-7
    BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.
    • $55
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • WAY-262611
    T19711123231-07-1
    WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.
    • $58
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • IWR-1
    T26511127442-82-3
    IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
    • $50
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Tegatrabetan
    T56421227637-23-1
    Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • WIC1
    T67923943083-58-7
    WIC1 is a potent Wnt inhibitor. WIC1 can be used in cancer research
    • $43
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • IWP-O1
    T53422074607-48-8
    IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
    • $37
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TNKS-2-IN-1
    T776754765-59-7
    TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity against E. coli and S. aureus.TNKS-2-IN-1 inhibits the release of IL-1β from the NLRP3 inflammasome (IC50: 5 μM) by inhibiting IL-1β release from ATP-stimulated J1A.774 cells.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Boehmenan
    TN352557296-22-7
    (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell
    • $276
    Backorder
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Wnt pathway inhibitor 3
    T77502663213-98-7
    Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.
    • $39
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • 2-Methoxystypandrone
    TN277585122-21-0
    2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant
    • $520
    Backorder
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Teplinovivint
    T91511428064-91-8
    Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.
    • $135
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • TINK-IN-1
    T776601417795-25-5
    TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.
    • $35
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • FIDAS-3
    T112841266684-01-8
    FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for MAT2A binding.
    • $33
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale