Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.

Cat. No.	Product name	CAS No.	Purity
T35556	GSK-3β inhibitor 8	1139875-74-3	98%
T35556	GSK-3β inhibitor 8 is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively reg...
T73415	Miclxin	2494198-61-5	98%
T73415	Miclxin is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutan...
T9556	TNIK-IN-3	2754265-25-1	98%
T9556	TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an I...
T9642	ZW4864 free base	2632259-92-6	98%
T9642	ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base)...
T24076	FzM1	1680196-54-6	98%
T24076	FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). F...
T9662	SRI 37892	1030769-75-5	98%
T9662	SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
T13345	Wnt pathway activator 2	1360540-82-4	98%
T13345	Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
T15137	DK419	2102672-22-8	98%
T15137	DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 an...
T60788	Carboxylesterase-IN-3	2764748-92-5	98%
T60788	Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.
T31987	Gossypolone	4547-72-2	98%
T31987	Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
TQ0215	Salinomycin sodium salt	55721-31-8	98%
TQ0215	Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
TN3468	Atractylochromene	203443-33-8	98%
TN3468	Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
TN1694	Gliotoxin	67-99-2	98%
TN1694	Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
TN3525	Boehmenan	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN3319	9-Hydroxycanthin-6-one	138544-91-9	98%
TN3319	9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
TMA1743	Ergosterol peroxide	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN2995	4,10-Aromadendranediol	70051-38-6	98%
TN2995	4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
T12537	β-catenin/CBP-IN-1	1198780-38-9	98%
T12537	β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
TP1565L	Foxy-5 acetate	TP1565L	98%
TP1565L	Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer ...