T35556 |
GSK-3β inhibitor 8
|
1139875-74-3
|
98%
|
|
GSK-3β inhibitor 8 is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively reg...
|
T73415 |
Miclxin
|
2494198-61-5
|
98%
|
|
Miclxin is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutan...
|
T9556 |
TNIK-IN-3
|
2754265-25-1
|
98%
|
|
TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an I...
|
T9642 |
ZW4864 free base
|
2632259-92-6
|
98%
|
|
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base)...
|
T24076 |
FzM1
|
1680196-54-6
|
98%
|
|
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). F...
|
T9662 |
SRI 37892
|
1030769-75-5
|
98%
|
|
SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
|
T13345 |
Wnt pathway activator 2
|
1360540-82-4
|
98%
|
|
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
|
T15137 |
DK419
|
2102672-22-8
|
98%
|
|
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 an...
|
T60788 |
Carboxylesterase-IN-3
|
2764748-92-5
|
98%
|
|
Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.
|
T31987 |
Gossypolone
|
4547-72-2
|
98%
|
|
Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
|
TQ0215 |
Salinomycin sodium salt
|
55721-31-8
|
98%
|
|
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
|
TN3468 |
Atractylochromene
|
203443-33-8
|
98%
|
|
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
|
TN1694 |
Gliotoxin
|
67-99-2
|
98%
|
|
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
TN3319 |
9-Hydroxycanthin-6-one
|
138544-91-9
|
98%
|
|
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
|
TMA1743 |
Ergosterol peroxide
|
2061-64-5
|
98%
|
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
|
TN2995 |
4,10-Aromadendranediol
|
70051-38-6
|
98%
|
|
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
|
TN2775 |
2-Methoxystypandrone
|
85122-21-0
|
98%
|
|
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
|
T12537 |
β-catenin/CBP-IN-1
|
1198780-38-9
|
98%
|
|
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
|
TP1565L |
Foxy-5 acetate
|
TP1565L
|
98%
|
|
Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer ...
|