β-cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39849	Propargite		Parasite
	Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC 50 of 1 μM [1] .		Parasite
T8982	RH01687		Others
	RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress.		Others
TN1019	Beta-mangostin	β-Mangostin	Apoptosis , Antibacterial , Parasite
	Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo...		Apoptosis , Antibacterial , Parasite
T9696	β-catenin-IN-2		Wnt/beta-catenin
	β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.		Wnt/beta-catenin
T13867	RH01386		Others
	RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ...		Others
TP1328	TB500		Others
	TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4.		Others
T2055	WS3		EGFR , IκB/IKK
	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.		EGFR , IκB/IKK
T76392	β-Bag cell peptide
	β-Bag cell peptide, a neuroactive peptide, elevates cyclic AMP levels and reduces the amplitudes of voltage-dependent potassium currents [1] in bag cell neurons.
T21902	ML351		Lipoxygenase
	ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).		Lipoxygenase
T15159	Dorzagliatin	HMS5552	Glucokinase
	Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.		Glucokinase
T1900	LDN-212854	LDN212854,BMP Inhibitor III	ALK , TGF-beta/Smad
	LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.		ALK , TGF-beta/Smad
TN1471	Cassiaside C	Toralactone 9-O-β-D-gentiobioside	Others , Endogenous Metabolite
	Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE).		Others , Endogenous Metabolite
T1674	Nateglinide	A4166,Senaglinide	Potassium Channel , Proteasome , PPAR
	Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins...		Potassium Channel , Proteasome , PPAR
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T7799	BMP signaling agonist sb4	SB 4	TGF-beta/Smad
	BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)		TGF-beta/Smad
T6496	Vactosertib	TEW-7197,EW-7197	ALK , TGF-beta/Smad
	Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...		ALK , TGF-beta/Smad
T1286	Vincamine	Angiopac,Oxybral,Devincan,Novicet,Equipur,Perval	GPR , Others
	Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.		GPR , Others
T1989	Luminespib	AUY922,VER-52296,NVP-AUY922	Apoptosis , HSP , Autophagy
	Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).		Apoptosis , HSP , Autophagy
T4864	Methyl β-D-Galactopyranoside	Methyl-β-D-galactopyranoside	Others , Endogenous Metabolite
	Within the cell, Methyl β-D-Galactopyranoside (Methyl-β-D-galactopyranoside) is primarily located in the cytoplasm. Outside of the human body, Methyl β-D-Galactopyranoside can be found in cereals and cereal products.		Others , Endogenous Metabolite