Search Result

Search Results for " mutation "

146

Compounds

Natural Products

463

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T77804	KRAS G12D mutation regulator 4

T83506	[Asn23]-beta-Amyloid (1-42), iowa mutation
	[Asn23]-beta-Amyloid (1-42), Iowa mutation, is a biologically active peptide exhibiting increased aggregation propensity and fibril toxicity. This mutation involves the substitution of Aspartic acid (Asp) at position 23 ...
T83509	[Arg6]-β-Amyloid (1-40), england mutation
	β-Amyloid (1-40), England mutation, is a biologically active peptide with a histidine (His) to arginine (Arg) substitution at position 6, known to enhance oligomerization kinetics that serve as fibril seeds and increase ...
T83508	[Arg6]-β-Amyloid (1-42), england mutation
	[Arg6]-β-Amyloid (1-42), England mutation, is a biologically active peptide associated with autosomal dominant Alzheimer's Disease in various kindreds. The English (H6R) mutation disrupts H6 interactions due to several m...
T83507	[Asn23] β-Amyloid (1-40), Iowa mutation
	[Asn23] β-Amyloid (1-40), Iowa mutation, is a biologically active peptide associated with autosomal dominant Alzheimer's Disease in multiple families. This specific mutation involves the substitution of Asp 23 with Asn, ...
T9117	BSJ-4-116		CDK , Ligand for E3 Ligase
	BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).		CDK , Ligand for E3 Ligase
T6878	LJI308		S6 Kinase
	LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.		S6 Kinase
T3196	GNF-7	GNF7	Bcr-Abl , ACK , AChR
	GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.		Bcr-Abl , ACK , AChR
T8684	Sotorasib	AMG-510	Ras
	Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ...		Ras
T22254	Alflutinib	AST2818,ASK120067	EGFR , P450
	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.		EGFR , P450
T7175	Alflutinib mesylate	AST2818 mesylate	EGFR
	Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.		EGFR
T1901	(E/Z)-TG003	TG003	BCL , CDK
	(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.		BCL , CDK
T15735	Leptomycin B	CI 940,LMB	CRM1 , Antibiotic , Antifungal
	Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a ...		CRM1 , Antibiotic , Antifungal
T2066	Quizartinib	AC220	Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC
	Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T3061	Lorlatinib	PF-6463922,PF-06463922,Loratinib	Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
	Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.		Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
T14489	Azvudine	FNC,RO-0622	HCV Protease , HBV , HIV Protease , Reverse Transcriptase
	Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1...		HCV Protease , HBV , HIV Protease , Reverse Transcriptase
T27154	Dexelvucitabine	D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC	Reverse Transcriptase
	Dexelvucitabine (RVT), a nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.		Reverse Transcriptase
T5462	Almonertinib	HS-10296	EGFR
	Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.		EGFR
T4575	Chromium picolinate		DNA , p38 MAPK
	Chromium picolinate causes DNA damage and mutation. It is an activator of p38.		DNA , p38 MAPK
T2464	ZMC1		p53
	NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).		p53
T3059	ALK-IN-1	AP26113,Brigatinib,AP26113-analog	EGFR , IGF-1R , ALK
	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.		EGFR , IGF-1R , ALK
T15550	IDH-305		Dehydrogenase
	IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (...		Dehydrogenase
T2245	CL-387785	WAY-EKI 785,EKI-785	EGFR
	CL-387785 (WAY-EKI 785)(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR(IC50： 370+/-120 pM); is able to overcome resistance caused by the T790M mutation on a functional level.		EGFR
T30293	Bamocaftor	VX-659	CFTR
	Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of c...		CFTR
T40544	NCGC00092410	ML008	Glucosidase
	NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.		Glucosidase
T5312	CFTR corrector 2	FDL169	CFTR , Autophagy
	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.		CFTR , Autophagy
T35901	EGFR-IN-99	JBJ-03-142-02	EGFR , HER
	EGFR-IN-99 (JBJ-03-142-02) is an EGFR and HER2 Exon 20 insertion mutation inhibitor with antiproliferative activity for the study of non-small cell lung cancer (NSCLC).		EGFR , HER
T60081	BV02	2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid	Others
	BV02 is an inhibitor of 14-3-3 protein-protein interactions and can be used in studies about the treatment of chronic myeloid leukemia. BV02 disrupts hematopoietic cells expressing the IM-resistant T315I mutation and the...		Others
T5675	Almonertinib hydrochloride	HS-10296 hydrochloride	EGFR
	Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.		EGFR
T72771	P53 Activator 7
	P53 Activator 7 is an activator of the p53 Y220C mutation (MDM-2/p53), featuring an EC50 value of 104 nM. It has the capability to bind to the mutated p53, reinstating its DNA-binding function.
T78170	Kras4B G12D-IN-1		Ras
	Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mut...		Ras
T5983	O-Phenanthroline	1,10-Phenanthroline	MMP , Others
	o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene m...		MMP , Others
T1623	Lopinavir	ABT-378	SARS-CoV , HIV Protease
	Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related dr...		SARS-CoV , HIV Protease
T2382	Vemurafenib	RO5185426,RG7204,PLX4032	Raf , MAPK , ACK , Src , Autophagy
	Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity and is used for the treatment of BRAF V600E mutation-positive...		Raf , MAPK , ACK , Src , Autophagy
T64338	AKI603	AKI 603,AKI-603	Aurora Kinase
	AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l...		Aurora Kinase
T2490	Osimertinib	AZD-9291,Mereletinib	EGFR
	Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irreversible and oral activity. Osimertinib has antitumor activi...		EGFR
T3336	Rg3039	PF-06687859	Others
	Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an...		Others
T79745	IDH2R140Q-IN-2		Dehydrogenase
	IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation ...		Dehydrogenase
T64124	Sunvozertinib	DZD9008,DZD 9008,DZD-9008	EGFR , BTK
	Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor and has inhibitory effects on EGFR, Her2 and mutant epidermal growth factor. Sunvozertinib showed inhibition of EGFR exon 20 NPH insertion, EGFR exon 20 ASV ins...		EGFR , BTK
T8756	KRAS inhibitor-9	DUN09716	Apoptosis , Ras
	KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS ...		Apoptosis , Ras
T69529	BI-0474		Ras
	BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G...		Ras
T3550	X-376	Ensartinib,X-396	c-Met/HGFR , ALK
	X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inh...		c-Met/HGFR , ALK
T25006	AGI-14100	AGI 14100	Dehydrogenase
	AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.		Dehydrogenase
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T60202	MMRi62	7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga...		Ferroptosis
T36141	Boscalid		Mitochondrial Metabolism
	Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehydrogenase.1It suppresses mycelial growth ofS. minorby 87 to ...		Mitochondrial Metabolism
T27555	HS-438	HS 438
	HS-438 inhibits imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.
T11159	EGFR-IN-2		EGFR
	EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.		EGFR
T11300	FLT3-IN-6		Others
	FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.		Others
T33219	MB725	MB 725,MB-725
	MB725 is a strong and selective inducer of viability reduction in several cancer cell lines containing the oncogenic p53-Y220C mutation.

Compounds

KRAS G12D mutation regulator 4

T77804

Synonym:

Target:

[Asn23]-beta-Amyloid (1-42), iowa mutation

T83506

Synonym:

Target:

[Arg6]-β-Amyloid (1-40), england mutation

T83509

Synonym:

Target:

[Arg6]-β-Amyloid (1-42), england mutation

T83508

Synonym:

Target:

[Asn23] β-Amyloid (1-40), Iowa mutation

Target: CDK, Ligand for E3 Ligase

Target: Bcr-Abl, ACK, AChR

Synonym: AST2818,ASK120067

Target: EGFR, P450

Alflutinib mesylate

T7175

Synonym: AST2818 mesylate

Target: CRM1, Antibiotic, Antifungal

Quizartinib

T2066

Synonym: AC220

Target: Apoptosis, FLT, Autophagy, Ligands for Target Protein for PROTAC

Lorlatinib

T3061

Synonym: PF-6463922,PF-06463922,Loratinib

Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase

Azvudine

T14489

Synonym: FNC,RO-0622

Target: HCV Protease, HBV, HIV Protease, Reverse Transcriptase

Dexelvucitabine

T27154

Synonym: D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC

Target: Reverse Transcriptase

Target: DNA, p38 MAPK

Synonym: AP26113,Brigatinib,AP26113-analog

Target: EGFR, IGF-1R, ALK

IDH-305

T15550

Synonym:

Target: Dehydrogenase

CL-387785

T2245

Synonym: WAY-EKI 785,EKI-785

Target: CFTR, Autophagy

EGFR-IN-99

T35901

Synonym: JBJ-03-142-02

Target: EGFR, HER

BV02

T60081

Synonym: 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid

Target: Others

Almonertinib hydrochloride

T5675

Synonym: HS-10296 hydrochloride

Synonym: 1,10-Phenanthroline

Target: SARS-CoV, HIV Protease

Vemurafenib

T2382

Synonym: RO5185426,RG7204,PLX4032

Target: Raf, MAPK, ACK, Src, Autophagy

AKI603

T64338

Synonym: AKI 603,AKI-603

Target: Aurora Kinase

Osimertinib

T2490

Synonym: AZD-9291,Mereletinib

Target: Dehydrogenase

Sunvozertinib

T64124

Synonym: DZD9008,DZD 9008,DZD-9008

Target: Apoptosis, Ras

Synonym: Ensartinib,X-396

Target: c-Met/HGFR, ALK

AGI-14100

T25006

Synonym: AGI 14100

Target: Dehydrogenase

PF 05089771 tosylate

T7502

Synonym:

Target: Sodium Channel

MMRi62

T60202

Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Target: Mitochondrial Metabolism

Synonym: MB 725,MB-725

Target:

Cat No.	Product Name	Synonyms	Targets
T22218	2'-Deoxyguanosine	Deoxyguanosine,Guanine deoxyriboside	Endogenous Metabolite
	2'-Deoxyguanosine (Guanine deoxyriboside) is a purine nucleoside that is recognized by members of the 2'-dG-II family.2'-Deoxyguanosine has been associated with aging, mutation, and carcinogenesis, and is oxidized by mol...		Endogenous Metabolite
T5293	Maltotriose	D-Maltotriose,Amylotriose	Others , Endogenous Metabolite
	Maltotriose (Amylotriose) is a common oligosaccharide metabolite found in human urine after maltose ingestion or infusion. Maltotriose is increased in Glycogen storage disease II due to a mutation of the enzyme alpha-1,4...		Others , Endogenous Metabolite
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T5267	N-Acetyl-L-glutamic acid	Ac-L-Glu-OH,N-Acetylglutamic acid	Others , Endogenous Metabolite
	N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) (NAcGlu) is an acetylated amino acid. NAcGlu is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetyl glutamate synthase (NAGS). NAcGlu activates carbamoyl phospha...		Others , Endogenous Metabolite
T30969	Clitocine		Apoptosis , BCL
	Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin...		Apoptosis , BCL
T83133	Alternaphenol B2		Isocitrate Dehydrogenase (IDH)
	Alternaphenol B2, a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1m), is sourced from the coral-derived fungus Parengyodontium album SCSIO SX7W11. It exhibits inhibitory activity specifically against the ...		Isocitrate Dehydrogenase (IDH)

Natural Products

2'-Deoxyguanosine

T22218

Synonym: Deoxyguanosine,Guanine deoxyriboside

Target: Endogenous Metabolite

Maltotriose

T5293

Synonym: D-Maltotriose,Amylotriose

Target: Others, Endogenous Metabolite

Gefitinib

T1181

Synonym: ZD1839

Target: EGFR, Tyrosine Kinases, Autophagy

N-Acetyl-L-glutamic acid

T5267

Synonym: Ac-L-Glu-OH,N-Acetylglutamic acid

Target: Others, Endogenous Metabolite

Clitocine

T30969

Synonym:

Target: Apoptosis, BCL

Alternaphenol B2

T83133

Synonym:

Target: Isocitrate Dehydrogenase (IDH)

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02337	Influenza A H3N2 Neuraminidase/NA Protein (E119V)	H3N2	HEK293
	Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the ho...
TMPY-02339	Influenza A H3N2 Neuraminidase/NA Protein (R292K)	H3N2	HEK293
	Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the ho...
TMPY-02338	Influenza A H3N2 Neuraminidase/NA Protein (N294S)	H3N2	HEK293
	Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the ho...
TMPY-04338	Influenza A H3N2 Neuraminidase/NA Protein (H274Y)	H3N2	HEK293
	Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the ho...
TMPY-01744	ACVR2A Protein, Human, Recombinant (His)	Human	HEK293
	ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately...
TMPY-01447	ACVR2A Protein, Mouse, Recombinant (His)	Mouse	HEK293
	ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately...
TMPY-00117	FGF-16 Protein, Human, Cynomolgus, Recombinant	Human,Cynomolgus	Baculovirus-Insect Cells
	Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the ME...
TMPY-02899	Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Apolipoprotein A1 (APOA1) is a member of the apolipoprotein family whose members are proteins bind with lipids and form lipoproteins to translate these oil-soluble lipids such as fat and cholesterol through lymphatic and...
TMPY-05350	CD8 alpha Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been imp...
TMPY-05364	CD8 alpha Protein, Human, Recombinant (hFc)	Human	HEK293
	T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been imp...
TMPY-05134	CD8 alpha Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
	T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been imp...
TMPY-01139	PDGFRA Protein, Human, Recombinant (His)	Human	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-01888	KRAS Protein,Human, Recombinant (Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-06056	KRAS Protein, Human, Recombinant (G12D, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-05750	Human coronavirus (HCoV-OC43) Spike S1 Protein (His)	HCoV-OC43	HEK293
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-05670	Human coronavirus (HCoV-NL63) Spike S1 Protein (His)	HCoV-NL63	HEK293
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-05674	Human coronavirus (HCoV-NL63) Spike Protein (S1+S2 ECD, His)	HCoV-NL63	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-05675	Human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECD, His)	HCoV-229E	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-03574	MERS-CoV Spike/S1 Protein (aa 1-725, His)	MERS-CoV	HEK293
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-06013	Human coronavirus (HCoV-OC43) Spike S2 Protein (His)	HCoV-OC43	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-05677	Human coronavirus (HCoV-OC43) Spike Protein (S1+S2 ECD, His)	HCoV-OC43	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-05671	Human coronavirus (HCoV-229E) Spike S1 Protein (His)	HCoV-229E	HEK293
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-03512	MERS-CoV Spike/S2 Protein (aa 726-1296, His)	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-05676	Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) Spike Protein (S1+S2 ECD, His)	HCoV-HKU1	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-02429	Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) Spike S1 Protein (His)	HCoV-HKU1	HEK293
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-00402	MERS-CoV Spike/RBD Protein fragment (aa 367-606, His)	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-03661	MERS-CoV Spike Protein (S1+S2 ECD, aa 1-1297, His)	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-01059	BMPR2 Protein, Human, Recombinant (His)	Human	HEK293
	The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin...
TMPY-01196	CD3D Protein, Human, Recombinant (His)	Human	HEK293
	T-cell surface glycoprotein CD3 delta chain, also known as CD3D, is a single-pass type I membrane protein. CD3D, together with CD3-gamma, CD3-epsilon and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heter...
TMPK-00436	SARS-COV-2 Spike S1 Protein (D614G, His & Avi)	SARS-CoV-2	HEK293
	The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic...
TMPK-00691	EGFRVIII Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPK-00692	EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPK-00689	EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPK-00690	EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled	Human	HEK293
	The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearran...
TMPY-02496	Rad6/UBE2A Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPY-04272	FcRH2/FCRL2 Protein, Human, Recombinant (His)	Human	HEK293
	Fc receptor-like 2 (FCRL2) is highly expressed on B-cell chronic lymphocytic leukemia (B-CLL) cells and could possibly influence disease pathogenesis. FCRL2 has robust predictive value for determining IGHV gene mutation ...
TMPY-00569	B3GAT3 Protein, Human, Recombinant (His)	Human	E. coli
	B3GAT3, encoding beta-1,3-glucuronyltransferase 3, has an important role in proteoglycan biosynthesis. Homozygous B3GAT3 mutations have been associated with short stature, skeletal deformities, and congenital heart defec...
TMPY-00368	ALR Protein, Human, Recombinant (His)	Human	HEK293
	Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consa...
TMPY-00452	SBDS Protein, Mouse, Recombinant (His)	Mouse	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disor...
TMPY-00518	SBDS Protein, Human, Recombinant (His)	Human	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disor...
TMPY-01380	Cyclophilin B Protein, Human, Recombinant (His)	Human	HEK293
	PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of th...
TMPK-01069	TMEM106B Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017...
TMPY-00181	Endothelin B Receptor Protein, Human, Recombinant (His)	Human	HEK293
	The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-re...
TMPY-03860	Endothelin B Receptor Protein, Human, Recombinant (mFc)	Human	HEK293
	The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-re...
TMPY-04633	Frizzled 2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	FZD2 may be a tumor suppressor gene in salivary adenoid cystic carcinomas (SACCs) that inhibits cell growth and migration. OMOD2 is a rare skeletal dysplasia and characterized by facial dysmorphism and shortness of the u...
TMPJ-01362	UBAP1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family membe...
TMPJ-01119	GPNMB Protein, Human, Recombinant (His)	Human	Human Cells
	Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one...
TMPY-01602	ACVR2A Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately...
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