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Cat No. | Product Name | Synonyms | Targets |
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T80183 | Muscarinic toxin 7 | ||
Muscarinic toxin 7 (MT7) is a peptide exhibiting selective, noncompetitive antagonistic activity at the muscarinic M1 receptor [1]. | |||
T80477 | Muscarinic toxin 3 | MT3 | Adrenergic Receptor |
Muscarinic toxin 3 (MT3), a potent non-competitive antagonist of mAChR and adrenoceptors, exhibits pIC50 values of 6.71 for M1, 8.79 for M4, 8.86 for α1A, 7.57 for α1B, 8.13 for α1D, 8.49 for α2A, <6.5 for α2B, and 7.29 ... | |||
T81893 | M1/M4 muscarinic agonist 2 | ||
Compound 40 is a selective M1/M4 muscarinic antagonist with an IC50 of 19 nM for M1 receptors and 42 nM for M4 receptors [1]. | |||
T11078 | Deschloroclozapine | Serotonin Transporter | |
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. | |||
T4981 | Anisotropine Methylbromide | Prostaglandin Receptor , AChR | |
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. | |||
T1760 | TBPB | AChR | |
TBPB is an allosteric M1 mAChR agonist. | |||
T11095L | DREADD agonist 21 | 5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor | |
DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM). | |||
T1281 | Tropicamide | Ro 1-7683 | AChR |
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ... | |||
T7555 | Piperidolate hydrochloride | AChR | |
Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs). | |||
T9419 | Fesoterodine | (R) Fesoterodine | AChR |
Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB). | |||
T9694 | Emraclidine | CVL-231 | AChR |
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies. | |||
T23116 | Oxotremorine sesquifumarate | AChR | |
Oxotremorine sesquifumarate is a muscarinic agonist. | |||
T2390 | Cevimeline hydrochloride hemihydrate | AChR | |
Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome. | |||
T28827 | Sofpironium bromide | BBI4000,BBI 4000,BBI-4000 | Others , AChR |
Sofpironium bromide (BBI4000) belongs to a class of drugs called anticholinergics, which exert their effect by blocking the action of acetylcholine. | |||
T6575 | LY2119620 | AChR | |
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. | |||
T4979 | Procyclidine hydrochloride | (±)-Procyclidine hydrochlorid | NMDAR , iGluR |
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties. | |||
T1475 | Fesoterodine fumarate | Toviaz,SPM 907 | AChR |
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... | |||
T5655 | MAChR-IN-1 hydrochloride | AChR | |
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm. | |||
T8219 | VU0238441 | AChR | |
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM. | |||
T13066 | TAK-071 | AChR | |
TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM). | |||
T17244 | VU0467154 | AChR | |
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively. | |||
T6548 | Irsogladine | Dicloguamine | PDE , AChR |
Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. | |||
T7405 | Piperidolate | AChR | |
Piperidolate inhibits intestinal cramp induced by acetylcholine | |||
T13325 | VU 0365114 | AChR | |
VU 0365114 is a positive allosteric modulator of mAChR M5 (EC50: 2.7 μM). | |||
T9420 | Prifinium bromide | Others | |
Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action. | |||
T23524 | W-84 dibromide | HDMPPA | AChR |
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator. | |||
T0794 | Mepenzolate Bromide | Colibantil,Cantil,Cantilaque | AChR |
Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions. | |||
T4997 | Umeclidinium bromide | GSK573719A | AChR |
Umeclidinium bromide (GSK573719A) is a novel mAChR antagonist. | |||
T3993 | BQCA | benzylquinolone carboxylic acid | AChR |
BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator. | |||
T13385 | Zamifenacin fumarate | UK-76654 fumarate | AChR |
Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor. | |||
T8224 | VU0119498 | AChR | |
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent. | |||
T4494 | CLOZAPINE N-OXIDE | Dopamine Receptor , 5-HT Receptor , AChR , Drug Metabolite | |
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopa... | |||
T0099 | Tolterodine tartrate | Detrol LA,PNU-200583E,Kabi-2234 | AChR |
Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo. | |||
T8383 | Cyclopentolate Hydrochloride | AChR | |
Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively. | |||
T1460 | Dicyclomine hydrochloride | AChR | |
Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. | |||
T9353 | OXOMEMAZINE | AChR , Histamine Receptor | |
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low ... | |||
T7002 | Trihexyphenidyl hydrochloride | Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride | AChR |
Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class. | |||
T9019 | JHU37152 | JHU 37152 | AChR |
JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... | |||
T23508 | VU 0255035 | AChR | |
muscarinic M1 antagonist | |||
T8007 | VU 0238429 | SCR-1481B1,VU0238429 | AChR |
VU 0238429 (SCR-1481B1) is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM). | |||
T0427 | Homatropine Methylbromide | Homatropine methobromide | AChR |
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. | |||
T16411 | Otenzepad | AF-DX 116 | AChR |
Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung. | |||
T29123 | VU0152099 | VU 0152099,VU-0152099 | AChR |
VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM). | |||
T9018 | JHU37160 | JHU 37160 | AChR |
JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... | |||
T1179 | Tiotropium bromide | Tiopropium,BA679 BR | AChR |
Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical a... | |||
T15942 | MK-7622 | M1 receptor modulator | AChR |
MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric. | |||
T3619 | VU0357017 hydrochloride | ML071 hydrochloride,CID-25010775,VU 0357017 hydrochloride | AChR |
VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15). | |||
T22380 | Nor-benzetimide | Others , AChR | |
Norbenzetimide, an organic compound, is prepared from benzetimide by catalytic transfer hydrogenolysis. | |||
T28069 | ML380 | ML 380,ML-380 | AChR |
ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM). | |||
T0720 | Gallamine triethiodide | Benzkurin,Flaxedil | AChR |
Gallamine triethiodide (Benzkurin), a synthetic inhibiting drug, is nondepolarizing. |
Cat No. | Product Name | Synonyms | Targets |
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T0962 | L-Hyoscyamine | Daturine,Hyoscyamine | AChR |
L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w... | |||
T8304 | Anisodamine Hydrobromide | 6-Hydroxyhyoscyamine | Adrenergic Receptor , AChR |
Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock. | |||
T8196 | Arborine | Arborin | Others , AChR |
Arborine (Arborin) is a larval growth inhibitor from glycoslnis pentaphylla. | |||
T2198 | Arecoline hydrobromide | Arecoline HBr,Arecoline bromide | AChR |
Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist. | |||
T5S0106 | Peimisine | Ebeiensine | RAAS , AChR |
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe... | |||
T1285 | Anethole trithione | Anetholtrithion | Others , AChR |
Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia. | |||
T4S1619 | L-Hyoscyamine sulfate | Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate | AChR |
L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits ... | |||
T1231 | Pilocarpine nitrate | Pilagan,Pilofrin | AChR |
Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. | |||
T0970 | Racanisodamine | Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine | Adrenergic Receptor , AChR |
Racanisodamine (7β-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock. | |||
T5805 | Guvacoline hydrochloride | Norarecoline hydrochloride | AChR |
Guvacoline hydrochloride (Norarecoline hydrochloride) is a muscarinic agonist. | |||
T0804 | Pilocarpine Hydrochloride | NSC 5746 HCl,Pilocarpine HCl,(+)-Pilocarpine hydrochloride | AChR |
Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy. | |||
TN1653 | Fustin | ERK , Beta Amyloid , AChR | |
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death. | |||
T6805 | Choline bitartrate | 2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium | Others , AChR |
Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcho... | |||
T7056 | Dronedarone | SR 33589 | P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy |
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. | |||
T1341 | Nortropine | Nortropenol | AChR |
Nortropine (Nortropenol) is used as muscarinic receptor antagonists. | |||
T21532 | Anisodamine | 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine | AChR |
Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine. Anisodamine improve the microcirculation ... | |||
T4727 | Taurolithocholic acid sodium salt | Sodium taurolithocholate | Others , Calcium Channel |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors. | |||
T4S0111 | Hupehenine | AChR | |
Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarinic receptors and cholinesterase inhibition. | |||
T68953 | Arecoline | Reactive Oxygen Species , AChR | |
Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can in... | |||
T0266 | Quinidine hydrochloride monohydrate | Quinidine hydrochloride | Potassium Channel , Sodium Channel , Parasite |
Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid... | |||
T6S0659 | Rhynchophylline | Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin | Calcium Channel , NF-κB |
1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c... | |||
TN2116 | Pteropodine | BCL , Calcium Channel , 5-HT Receptor | |
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic l... | |||
TN4342 | Izalpinine | Others | |
Izalpinin exhibits potent antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Izalpinin exhibits inhibitory role of muscarinic receptor-related detrusor contractile activity, and it may be a promisi... | |||
TN1790 | Isopteropodine | Uncarine E | 5-HT Receptor , Antibacterial , AChR |
Isopteropodine (Uncarine E) is an isoyohimbine-type octindole alkaloid isolated from Hamelia patens micropropagated and has antimicrobial activity and stimulates the immune system. Isopteropodine has antimicrobial activi... | |||
T73856 | Anagyrine hydrochloride | ||
Anagyrine hydrochloride ((-)-Anagyrine hydrochloride), a quinolizidine alkaloid discovered in Lupinus albus, interacts with both muscarinic and nicotinic acetylcholine receptors, demonstrating IC50 values of 132 and 2096... |
Cat No. | Product Name | Species | Expression System |
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TMPY-02286 | Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1/M1 Protein (His) | H1N1 | E. coli |
The Influenza virus matrix protein 1 (M1) is a matrix protein of the influenza virus. M1 protein has been shown to play a crucial role in virus replication, assembly, and budding. It forms a coat inside the viral envelop... | |||
TMPY-00496 | Influenza A H1N1 (A/Brevig Mission/1/1918) Matrix protein 1/M1 Protein (His) | H1N1 | E. coli |
The Influenza virus matrix protein 1 (M1) is a matrix protein of the influenza virus. M1 protein has been shown to play a crucial role in virus replication, assembly, and budding. It forms a coat inside the viral envelop... | |||
TMPY-03844 | Influenza A H7N9 (A/Anhui/1/2013) Matrix protein 1/M1 Protein (His) | H7N9 | E. coli |
The Influenza virus matrix protein 1 (M1) is a matrix protein of the influenza virus. M1 protein has been shown to play a crucial role in virus replication, assembly, and budding. It forms a coat inside the viral envelop... | |||
TMPY-00498 | Influenza A H3N2 (A/Aichi/2/1968) Matrix protein 1/M1 Protein (His) | H3N2 | E. coli |
The Influenza virus matrix protein 1 (M1) is a matrix protein of the influenza virus. M1 protein has been shown to play a crucial role in virus replication, assembly, and budding. It forms a coat inside the viral envelop... | |||
TMPH-01714 | CHRM1 Protein, Human, Recombinant (His) | Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ... | |||
TMPH-03338 | CHRM1 Protein, Rat, Recombinant (His) | Rat | E. coli |
CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli. | |||
TMPH-01715 | CHRM2 Protein, Human, Recombinant (His) | Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ... | |||
TMPH-01716 | CHRM3 Protein, Human, Recombinant (B2M & His) | Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ... | |||
TMPH-01717 | CHRM5 Protein, Human, Recombinant (His) | Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. ... |
Cat No. | Product Name | ||
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L9830 | Anti-Parkinson's Disease Compound Library | 908 compounds | |
A unique collection of 908 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS. |