lipoprotein — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T73610	Lipoprotein lipase
	Lipoprotein lipase, a multifunctional enzyme present in adipose tissue, heart, skeletal muscle, islets, and macrophages, plays a crucial role in normal lipoprotein metabolism, and the distribution and utilization of tiss...
T2499	Torcetrapib	CP-529414	CETP
	Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces...		CETP
T5S0246	Pseudoprotodioscin		Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.		Others , Fatty Acid Synthase
T7832	Ibrolipim	NO-1886	LPL Receptor
	Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.		LPL Receptor
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T1510	Rosuvastatin calcium	ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.		Potassium Channel , HMG-CoA Reductase , Autophagy
T15549	Icosabutate		Others
	Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist...		Others
T16751	Rilapladib	SB 659032	Phospholipase
	Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activating factor receptor.		Phospholipase
T19861	Niceritrol	Perycit,Cardiolipol,Bufor	Others
	Niceritrol (Cardiolipol) is a niacin ester that reduces cholesterol and triglycerides in total plasma and in the VLD and LD lipoprotein fractions.		Others
T1415	Gemfibrozil	CI-719,Jezil,Decrelip,Lopid	P450 , Adrenergic Receptor , PPAR
	Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...		P450 , Adrenergic Receptor , PPAR
T13600	CDD3505	4-nitro-1-trityl-1H-imidazole	P450
	CDD3505 (4-nitro-1-trityl-1H-imidazole) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450
T6109	Darapladib	SB-480848	Phospholipase
	Darapladib (SB-480848)(IC50=0.25 nM) is a substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2).		Phospholipase
T25701	Levosemotiadil	SD 3212,SA 3212	LDL , Calcium Channel
	Levosemotiadil（SA 3212） is a novel calcium antagonist and a very potent inhibitor of low-density lipoprotein oxidation.Levosemotiadil may be used to prevent lethal cardiac arrhythmias.		LDL , Calcium Channel
T11874	Lp-PLA2-IN-3		Phospholipase
	Lp-PLA2-IN-3 is a potent and orally bioactive lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor that inhibits recombinant human Lp-PLA2 with an IC50 value of 14 nM.		Phospholipase
T11386L	Gemcabene	PD-72953	Others
	Gemcabene (PD-72953) is a lipid-lowering agent with anti-inflammatory activity. Gemcabene lowers low-density lipoprotein cholesterol and triglycerides, raises high-density lipoprotein cholesterol, and decreases pro-infla...		Others
T41160	Lalistat 2		Lipase
	Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).		Lipase
T30577	BRD0418	BRD 0418,BRD-0418	Others
	BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.		Others
T31204	Darapladib-impurity		Others
	Darapladib-impurity is the impurity of Darapladib. Darapladib inhibits lipoprotein-associated phospholipase A2 (Lp-PLA2).		Others
T77695	Muvalaplin	LY3473329	Others
	Muvalaplin (LY3473329) is an orally active lipoprotein (a) Lp(a) reagent that inhibits Lp(a) formation by blocking apo(a)-apo B100 interactions.		Others
T13601	CDD3506	1-TRITYL-1H-IMIDAZOL-4-AMINE	P450
	CDD3506 (1-TRITYL-1H-IMIDAZOL-4-AMINE) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450