al 1

AL-1 is a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It can mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It exists in a variety of adult tissues of BRAIN; HEART;

AL 1965 has anti-neuropathic effects.

AL 1612 is a bio-active chemical.

Heptanal 1,3-glyceryl acetal is a bioactive chemical.

BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.

KP136 (AL136) is an orally active anti-allergic compound that inhibits histamine release and is used in studies of asthma and allergic edema.

Alconil (Al 1567) is an aldose reductase inhibitor that may be used to study chronic obstructive pulmonary disease (COPD) and diabetes.

Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α/β/γ.

Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.

Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.

iKIX1 is an Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection.

M617 acetate is a selective agonist of galanin receptor 1 (GAL1). M617 acetate acts through central GAL1, promotes GLUT4 expression, and enhances GLUT4 content in the cardiac muscle of type 2 diabetic rats. The Ki values are 0.23 and 5.71 nM for GAL1 and GAL2, respectively.

Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations. Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID:29723265

CAL-130 is a PI3Kδ and PI3Kγ inhibitor [IC50s: 1.3 and 6.1 nM].

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).

CAL-130 Racemate, the racemate of CAL-130, is a PI3Kδ and PI3Kγ inhibitor with IC50s of 1.3 and 6.1 nM, respectively.

Idelalisib-D5, a version of Idelalisib (T8651) marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.

a-Santal-10-en-12-oic acid is a useful organic compound for research related to life sciences. The catalog number is T124279 and the CAS number is 74642-79-8.

LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.

SirReal1-O-propargyl is a selective Sirtuin 2 inhibitor (IC50=2.4 μM) and PROTAC ligand. Its propargyl group enables click chemistry reactions such as CuAAc.

Methamnetamine (PAL-1046) hydrochloride is a psychoactive substance derived from phenethylamine, known to cause excessive serotonin release.

AAL-149, an analog of FTY720 and a TRPM7 inhibitor (IC50 = 1.081 μM), exhibits multiple anti-inflammatory effects without targeting S1P receptors. It is applicable in anti-inflammatory research.

ST6GAL1-IN-1 (compound 4e) is a potent selective inhibitor of ST6GAL1, with an IC50 value of 20.0 μM. It demonstrates anti-metastatic activity by effectively inhibiting the migration of MDA-MB-231 cells. Furthermore, ST6GAL1-IN-1 is capable of suppressing tumor growth and metastasis in vivo.

BAL-1516 is a brain-penetrant and highly selective NLRP3 inhibitor (IC50=14.2 nM). It significantly inhibits the release of interleukin-1β and interleukin-18 in microglial neuroinflammation models (IC50=11-59 nM). BAL-1516 holds potential for research in neurodegenerative diseases, such as Alzheimer's and Parkinson's, as well as systemic inflammatory disorders.