TSH

D-Thyroxine (Dextroxin) could lower cholesterol and also increases hepatic lipase which in turn improves utilization of triglycerides, leading to improve apolipoprotein E cholesterol particles.

Thyrotropin (TSH), a thyroid-stimulating hormone, is synthesized by thyrotrope cells in the anterior pituitary gland and modulates the endocrine activity of the thyroid [1] [2].

TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).

VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.

ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)

NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies.

ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism.

Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism.

D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.

Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab reduces TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used in the study of thyroid-associated eye diseases.

Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.

TSHR antagonist S37a is a selective, orally bioavailable TSHR (thyroid-stimulating hormone receptor) antagonist that inhibits TSH-induced cyclic adenosine monophosphate (cAMP) in TSHR-expressing HEK 293 cells, suitable for studying Graves' orbitopathy.

Anti-TSHR Antibody (M22) is a and highly specialized stimulating monoclonal antibody that targets the thyrotropin receptor (TSHR) to mimic the biological activity of thyroid-stimulating hormone and facilitate the measurable activation of cyclic AMP signaling pathways across various endocrine and immunological experimental models.

TSHR antagonist S37b, the less potent enantiomer of TSHR antagonist S37a, exhibits minimal efficacy in inhibiting the thyrotropin receptor (TSHR). It is utilized in thyroid function research[1].

Apoptozole (Apoptosis Activator VII) inhibits the ATPase domain of Hsc70 and Hsp70, inducing apoptosis.

TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated molecular chaperone and anti-inflammatory activity, and enhances Hsp72 expression in neurons and glial cells.

ML346 is a novel activator of Hsp70.

Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.

VER-155008 is an Hsp70 inhibitor (IC50 = 0.5 μM), exhibiting over 100-fold selectivity against Hsp90, and capable of inhibiting Hsc70 and Grp78 (IC50 = 2.6 μM for both). This compound possesses good selectivity and cell permeability, and is used in anti-tumor research, showing therapeutic potential in leukemia and solid tumor models.

Manganese chloride tetrahydrate is a high-purity manganese salt that can serve as a cofactor for enzyme reactions and provide essential trace elements in cell culture, and is commonly used in biochemical experiments.

Heptanoic acid sodium is the sodium salt of Heptanoate.The C(5) ketogenicity of Heptanoate is much lower than the C(4) ketogenicity of octanoate, and it can inhibit the osteoporosis and gluconeogenesis of Heptanoate.

Trans-1,2-Cyclohexanediaminetetraacetic acid (CDTA) is a cyclohexane derivative and a multidentate chelating agent with strong chelating ability towards divalent and trivalent metal ions, comparable to EDTA. It is commonly used as a metal ion chelating agent, titrant, and radiopharmaceutical ligand.

2-Amino-2-methyl-1,3-propanediol is an activator of 2-oxoaldehyde dehydrogenase and can also be used as a solid-solid phase change material (PCM) and biological buffer.