lap

LAP is a highly efficient and biocompatible radical photoinitiator used to initiate radical chain polymerisation and synthesise polymeric materials under light irradiation. The primary wavelength for light absorption and polymerisation initiation is 405 nm. LAP concentrations ≥3.4 mmol/L and the radicals it generates exhibit cytotoxicity towards M-1 mouse renal collecting duct cells.

Rolapitant Intermediate, known scientifically as ((3R,7aR)-3-(tert-Butyl)-1-hydroxy-7a-vinyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one), serves as a pharmaceutical intermediate used in the synthesis of various active compounds.

1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is a cylindrical-shaped lipid used to synthesize liposomes. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is the lipid component in the lipid nanoparticle (LNP) system.

Polysaccharidase (Tremella polysaccharide), a fungal polysaccharide, exhibits immunoenhancing properties and holds potential for research in mitigating chemotherapy and radiotherapy-induced leukopenia [1] [2].

Alkaline Phosphatase (ALP), Human Placental (ALP, PLAP, Alk Phos), serves as a biological material or organic compound useful for life science research.

L-Alanine 4-nitroanilide hydrochloride, 99% (Ala-4-nitroanilide, 99%; H-Ala-pNA, 99%) serves as a substrate for the detection of L-alanine aminopeptidase.

Ala-Phe-Pro-pNA TFA serves as a chromogenic substrate for tripeptidyl peptidase and can be utilized to assess the enzyme's activity.

Ala-Ala-Phe-AMC is a fluorescent substrate with a positively charged characteristic, suitable for assessing proteolytic activity.

DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala dipeptide sequence can be cleaved by cathepsin B. The DBCO group is typically utilized in click chemistry reactions. The PEG spacer enhances the compound's solubility in water. PNP serves as an effective leaving group.

Fmoc-Ala-Ala-Pro-OH is an Fmoc-protected tripeptide linker utilized in the synthesis of antibody-drug conjugates (ADC).

Alloc-Val-Ala-PAB is a cleavable peptide linker employed in the synthesis of antibody-drug conjugates (ADC). The Val-Ala sequence is specifically cleaved by cathepsin B. The Alloc group remains stable when treated with piperidine and TFA, yet it can be easily removed under mild conditions via palladium-catalyzed allyl transfer.

Maleimide-PEG8-Val-Ala-PAB is an ADC linker composed of a cleavable Val-Ala-PAB linker and the probe molecule Maleimide. It is used to connect the monoclonal antibody Cetuximab with the CDK inhibitor SNS-032 for the synthesis of antibody-drug conjugates (ADC).

(2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride [Telaprevir Intermediate 4] is a pharmaceutical intermediate utilized in the synthesis of various active compounds.

Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is a gelatin methacryloyl compound infused with green fluorescent molecules. This modification allows Green Fluorescent GelMA to function as a scaffold, facilitating the design of tissue models ranging from vascular systems to cartilage and bone, and promoting cell proliferation and dispersion. With 30% methacrylation and Green Fluorescent properties, it requires photo-initiator LAP to self-assemble into fibrous hydrogels, targeting bioactive adhesive sites to provide structural support and enable biodegradation. Its applications include cell culture, bio 3D printing, tissue engineering, among others.

GelMA (Gelatin Methacryloyl), with 60% methacrylation and Green Fluorescent properties, is a type of methylated gelatin incorporating fluorescent molecules. This compound functions as a scaffold for creating tissue analogs, such as those resembling the vascular system, cartilage, and bone, promoting cell proliferation and diffusion. To form fibrous hydrogels, GelMA requires the action of a photoinitiator LAP, allowing it to target bioactive adhesion sites to support and degrade in tissue cells. It is applicable in fields like cell culture, bio 3D printing, and tissue engineering.

GelMA (Gelatin Methacryloyl), with 90% methacrylation and green fluorescence, is a modification of gelatin achieved by grafting fluorescent molecules onto the polymer. Green Fluorescent Gelatin Methacryloyl acts as a scaffold beneficial for creating tissue analogs ranging from the vascular system to cartilage and bone, promoting cell proliferation and diffusion. In the presence of the photoinitiator LAP, GelMA self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing essential support and biodegradability for tissue cells. Applications encompass cell culture, bio 3D printing, tissue engineering, among others.

Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is a variant of methacryloylated gelatin with red fluorescence, achieved by grafting fluorescent molecules onto GelMA. It acts as a scaffold and is suitable for designing tissue analogs from the vascular system to cartilage and bones, facilitating cell proliferation and dissemination. With 30% methacrylation, Red Fluorescent GelMA requires light initiator LAP to self-assemble into fibrous hydrogels, targeting bioactive adhesion sites while providing inherent support and biodegradability. Applications include cell culture, biological 3D printing, tissue engineering, and more.

Gelatin Methacryloyl, 30% methacrylation, blue fluorescent (GelMA, 30% methacrylation, blue fluorescent) is a type of GelMA that incorporates blue fluorescent molecules through its structure. It acts as a scaffold for creating tissue analogs, such as those of the vascular, cartilage, and skeletal systems, promoting cell proliferation and diffusion. Upon exposure to the photoinitiator LAP, it self-assembles into fibrous hydrogels, targeting bioactive adhesion sites to inherently support tissue cells and facilitate biodegradation. Applications include cell culture, bioprinting, and tissue engineering.

Chondroitin Sulfate Methacryloyl (CSMA) is a methacryloyl-modified form of chondroitin sulfate known for its biocompatibility. It exhibits a higher degree of methacrylic substitution compared to HAMA , which is closely linked to customizable mechanical properties, swelling behavior, and enzymatic degradability. CSMA serves as a versatile biomaterial suitable for biomimetic hydrogel scaffolds and is an ideal hydrogel ink for 3D printing. Under the influence of photoinitiator LAP, it self-assembles into a fibrous hydrogel targeting bioactive adhesion sites, supporting tissue cell interaction and biodegradation. It is applicable in areas such as cell culture, biological 3D printing, and tissue engineering.

Dextran Methacryloyl (MW 200000) is a methacrylated glucan that can transform into a cell matrix gel. The gel formed from Dextran Methacryloyl (MW 200000) shows no cytotoxicity towards fibroblasts, although cells exhibit only limited adhesion in prolonged experiments. In the presence of the photoinitiator LAP, it self-assembles into a fibrous hydrogel that targets bioactive adhesion sites, providing inherent support and biodegradability for tissue cells. It is applicable in areas such as cell culture, bio 3D printing, and tissue engineering.

Dextran Methacryloyl (DexMA) (MW 500000) is a methacrylated dextran that can transform into a cell matrix gel. The gel formed by Dextran Methacryloyl (MW 500000) is non-cytotoxic to fibroblasts; however, cell adhesion in long-term experiments is only marginally effective. Under the influence of the photoinitiator LAP, Dextran Methacryloyl (MW 500000) self-assembles into fibrous hydrogels that target bioactive adhesion sites, providing inherent support and biodegradation activity for tissue cells. Application areas include cell culture, bio 3D printing, and tissue engineering.

GelMA (Gelatin Methacryloyl), with 60% methacrylation and red fluorescence, is a modified version of GelMA created by grafting fluorescent molecules onto it. It serves as a scaffold, facilitating the design of tissue analogs ranging from the vascular system to cartilage and bone, thus promoting cell proliferation and diffusion. In contrast, GelMA, 60% methacrylation with green fluorescence, requires LAP as a photoinitiator to self-assemble into fibrous hydrogels and target bioactive adhesion sites, providing inherent support to tissue cells and promoting biodegradability. This compound finds applications in cell culture, 3D bioprinting, and tissue engineering.

Gelatin Methacryloyl (GelMA) with 90% methacrylation and blue fluorescence is a modified form of gelatin achieved through the attachment of fluorescent molecules to GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold, facilitating the design of tissue analogs from vascular systems to cartilage and bone, promoting cell proliferation and migration. For GelMA with 90% methacrylation and green fluorescence, it requires the presence of a photoinitiator, specifically LAP, to self-assemble into fibrous hydrogels. These hydrogels target bioactive adhesion sites, providing inherent support for tissue cells and contributing to biodegradability. Applications include cell culture, bio 3D printing, and tissue engineering.

Alginate Methacryloyl (AlgMA) (MW 300000) is a methacryloyl-modified alginate known for its potential use in tissue engineering scaffolds and 3D printing inks. This compound exhibits biocompatibility, non-immunogenicity, and low toxicity, and can physically crosslink with divalent cations such as calcium. Under the influence of photoinitiator LAP, AlgMA self-assembles into fibrous hydrogels, targeting bioactive adhesion sites to provide inherent support to tissue cells and facilitate biodegradation. It is applicable in fields such as cell culture, biological 3D printing, and tissue engineering.