AS 100

AS100 is a bioactive chemical.

GPX-100 (13-deoxydoxorubicin) is an analogue of the anthracycline antitumour antibiotic doxorubicin. GPX-100 inserts into DNA and interacts with topoisomerase II to inhibit DNA replication and repair as well as RNA and protein synthesis.

ABT-100 is a potent, highly selective, and orally active inhibitor of farnesyl transferase [farnesyl-protein transferase] with broad-spectrum antitumor activity.

RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.

FV-100 (Valnivudine HCl) is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo.FV-100 is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo.

(Iso)-RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC 50 s of 6.4 and 7.2, respectively.

Triton X-100 is a non-denaturing detergent that solubilizes lipid membranes. Triton X-100 is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Triton X-100 is listed as an excipient in certain vaccines including split virus influenza vaccines. Triton X-100 is a nonionic surfactant [1] [2].

Hyaluronic acid sodium (MW 100 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.

CLIP 86-100 acetate(648881-58-7 free base) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide called CLIP. The major histocompatibility complex class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the binding groove, a place-holding peptide CLIP is removed. CLIP 86-100 acetate(648881-58-7 free base) is accomplished by the molecule DM, which is shown to increase the dissociation rate of a CLIP peptide from class II.

AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD).

TU-100 is frequently used in the treatment of chronic gastrointestinal disorders, and it is commonly applied to alleviate symptoms such as abdominal pain, bloating, Crohn’s disease, irritable bowel syndrome, adhesive intestinal obstruction, and paralytic ileus. Additionally, TU-100 can improve gastrointestinal motility abnormalities in patients with grade B liver impairment after hepatectomy and reduce serum CRP levels.

E3LigaseLigand-linker Conjugate 100 is a conjugate of an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and its corresponding linker. E3LigaseLigand-linker Conjugate 100 functions as a Cereblon ligand to recruit CRBN protein and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.

TR-100 is a small molecule inhibitor targeting tumor-associated tropomyosin (Tpm). It binds to the C-terminus of Tpm3.1, affecting its interaction with actin filaments and thus influencing their stability and function. This mechanism allows TR-100 to specifically affect actin filament bundles in cancer cells without impairing cardiac muscle function. TR-100 is useful for studying the role of Tpm3.1 in cancer cell proliferation and survival, as well as its impact on insulin-stimulated glucose uptake and insulin secretion.

Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9, activates the proprotein form of caspase-1 independent of the inflammasome adaptor ASC[2]. Talabostat competitively inhibits the dipeptidyl peptidase (DPP) activity of FAP and CD26/DPP-IV, and there is a high-affinity interaction with the catalytic site due to the formation of a complex between Ser630/624 and the boron of talabostat[3]. Talabostat can stimulate immune responses against tumors involving both the innate and adaptive branches of the immune system. In WEHI 164 fibrosarcoma and EL4 and A20/2J lymphoma models, PT-100 causes regression and rejection of tumors. The antitumor effect appears to involve tumor-specific CTL and protective immunological memory. Talabostat treatment of WEHI 164-inoculated mice increases mRNA expression of cytokines and chemokines known to promote T-cell priming and chemoattraction of T cells and innate effector cells[3]. Talabostat treated mice show significant less fibrosis and FAP expression is reduced. Upon PT100 treatment, significant differences in the MMP-12, MIP-1α, and MCP-3 mRNA expression levels in the lungs are also observed. Treatment with PT100 in this murine model of pulmonary fibrosis has an anti-fibro-proliferative effect and increases macrophage activation[4]. [1]. Connolly BA, et al. Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potencyand in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13. [2]. Okondo MC, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017 Jan;13(1):46-53. [3]. Adams S, et al. PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res. 2004 Aug 1;64(15):5471-80. [4]. Egger C, et al. Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. Eur J Pharmacol. 2017 Aug 15;809:64-72.

HA-100 hydrochloride is a powerful protein kinase inhibitor, exhibiting IC50 values of 4 μM, 8 μM, 12 μM, and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and MLC-kinase, respectively. Additionally, HA-100 hydrochloride is utilized as a ROCK inhibitor.

GAT100 is a potent and covalent negative allosteric modulator (NAM). GAT-100 behaved as a robust positive allosteric modulator of binding of orthosteric agonist CP55,940. This novel covalent probe can serve as a useful tool for characterizing CB1R allosteric ligand-binding motifs.

Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].

Gp100:209-217, a gp 100-derived human CTL epitope presented by HLA-A2, is an eight-amino-acid polypeptide that acts as a potent TGF-β inhibitor, blocking the TGF-β signaling pathway [1].

Gp100 (619-627) acetate refers to the amino acid fragment 619 to 627 of the human melanoma antigen glycoprotein 100 (gp100). This compound has been extensively studied as a target in melanoma immunotherapy research.

Dimethyl silicone oil, viscosity 100 cSt (25 °C) (Poly(dimethylsiloxane) (PDMS), viscosity 100 cSt (25 °C); Dimethylsilcone fluid, viscosity 100 cSt (25 °C)) is a biochemistry reagent.

Polyoxyethylene (100) stearyl ether is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

100 mM Pro-Ac, pH 5.0 buffer is a biochemical reagent used as a reconstitution buffer for ADC products.

ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).

ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100, an activator of the stimulator of interferon genes (STING).