ap2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12885	SGC-AAK1-1		AAK1 (AP2 associated kinase 1)
	SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.		AAK1 (AP2 associated kinase 1)
T15781	LP-935509		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
	LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-...		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
T68455	AP23846	AP-23846	Src
	AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines.		Src
T14299	AP20187	B/B Homodimerizer	Others
	AP20187 (B/B Homodimerizer) is a cell-permeable compound employed to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein...		Others
T62861	ERAP2-IN-1
	ERAP2-IN-1 (compound 61) is a non-competitive inhibitor of ERAP2. ERAP2-IN-1 specifically inhibits the hydrolytic activity of ERAP2 peptides, inhibiting Arg-AMC hydrolysis (IC50: 27 μM) and the hydrolytic activity of mod...
T63986	SAP2-IN-1
	SAP2-IN-1 is a secreted aspartate protease 2 (SAP2) inhibitor that exhibits potent SAP2 inhibition (IC50: 0.92 μM). SAP2-IN-1 is also a virulence factor inhibitor and is not active in vitro. SAP2-IN-1 can be used to stud...
T82683	Connexin mimetic peptide 40GAP27
	Connexin mimetic peptide 40GAP27, corresponding to the GAP27 domain of the second extracellular loop of the dominant vascular connexin (Cx40), designated as 40Gap27, is a biologically active peptide utilized to study the...
T82684	Connexin mimetic peptide 40,37GAP26
	Connexin mimetic peptide 40,37GAP26, a biologically active peptide, matches the GAP26 domain of the extracellular loop of major vascular connexins Cx37 and Cx40, referred to as 37,40Gap26 based on Cx homology. It has bee...
T36240	AP219
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an ...
T68325	AP24163
	AP24163 is an inhibitor of the gatekeeper mutant of BCR-ABL, thereby suppressing in vitro resistance.
T68607	AP23848
	AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.
TP2123	ShK-Dap22
	Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4...
T78129	MetAP2-IN-1		Others
	MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].		Others
T68581	AP23464
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ab...
T69700	BAP2
	BAP2 is a novel inhibitor of protein disulfide isomerase (PDI).
T7621	6-Thioinosine	6-Mercaptopurine riboside,6TI	Nucleoside Antimetabolite/Analog
	6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.		Nucleoside Antimetabolite/Analog
T15506	HTS01037		Others
	HTS01037 is an inhibitor of fatty acid-binding. HTS01037 is a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).		Others
T77333L	(Iso)-BMT-124110 Formate	(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）	AAK1 (AP2 associated kinase 1)
	(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease.		AAK1 (AP2 associated kinase 1)
T34630	SGC-AAK1-1N	SGCAAK11N,SGCAAK1-1N,SGC-AAK11N
	SGC-AAK1-1N is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) with an IC 50 of 1.8 μM [1].
T63355	BMS-309403 sodium
	BMS-309403 sodium is a potent, orally active, selective inhibitor of the adipocyte fatty acid binding protein (FABP4, aP2), demonstrating inhibitory constants (K i ) of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, re...