T22319 |
DTP3
|
1809784-29-9
|
98%
|
|
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
|
TN2775 |
2-Methoxystypandrone
|
85122-21-0
|
98%
|
|
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
|
T11721 |
JDTic
|
361444-66-8
|
98%
|
|
JDTic has a very long duration of action, with effects in animals seen for up to several weeks after administration of a single dose, although its binding to the...
|
T15606 |
JAK1-IN-4
|
2091134-35-7
|
98%
|
|
JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively). JAK1-IN-4 inhibits STAT3 phosphorylation in NC...
|
T10424 |
AZ-3
|
2228908-91-4
|
98%
|
|
AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).
|
TN2002 |
Obovatol
|
83864-78-2
|
98%
|
|
Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treat...
|
TMA1743 |
Ergosterol peroxide
|
2061-64-5
|
98%
|
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
|
TN3541 |
Broussonin E
|
90902-21-9
|
98%
|
|
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
|
T11690 |
ITK inhibitor 2
|
1309784-09-5
|
98%
|
|
ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor , with an IC50 of 2 nM.
|
TN4774 |
Physalin A
|
23027-91-0
|
98%
|
|
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
|
T11711 |
Jaspamycin
|
22242-96-2
|
98%
|
|
Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity. Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to th...
|
TN3364 |
Agrimonolide
|
21499-24-1
|
98%
|
|
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of ...
|
T12091 |
MM-589
|
2097887-20-0
|
98%
|
|
MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.
|
T12091L |
MM-589 TFA
|
2097887-21-1
|
98%
|
|
MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.
|
T15037 |
Momelotinib Mesylate
|
1056636-07-7
|
98%
|
|
Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.
|
T11709 |
JAK3 covalent inhibitor-1
|
2300106-50-5
|
98%
|
|
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.
|
T3066 |
S-Ruxolitinib
|
1160597-27-2
|
98%
|
|
Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivi...
|
T15038 |
Momelotinib sulfate
|
1056636-06-6
|
98%
|
|
Momelotinib sulfate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.
|
T11713 |
JBJ-02-112-05
|
T11713
|
98%
|
|
JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC 50 of 15 nM for EGFR L858R/T790M [1].
|
T11708 |
JAK2-IN-4
|
1438284-00-4
|
98%
|
|
JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.
|