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RAI-20
(Synonyms: H018) Copy Product Info
🥰Excellent
Synonyms: H018
Catalog No. T218441 Copy Product Info
🥰Excellent
RAI-20 (H018) is an orally bioavailable dual inhibitor of JAK1 and JAK2, with IC50 values of 15.1 and 22.7 nM, respectively. It exhibits excellent pharmacokinetic properties, including plasma stability, systemic exposure, and a prolonged half-life. In a collagen-induced arthritis rat model, RAI-20 demonstrates significant anti-inflammatory and anti-arthritic activities, effectively reducing paw swelling volume and the arthritis index. RAI-20 serves as a useful compound for research into the pathogenesis of rheumatoid arthritis.
RAI-20
Cas No. 2549180-90-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RAI-20 (H018) is an orally bioavailable dual inhibitor of JAK1 and JAK2, with IC50 values of 15.1 and 22.7 nM, respectively. It exhibits excellent pharmacokinetic properties, including plasma stability, systemic exposure, and a prolonged half-life. In a collagen-induced arthritis rat model, RAI-20 demonstrates significant anti-inflammatory and anti-arthritic activities, effectively reducing paw swelling volume and the arthritis index. RAI-20 serves as a useful compound for research into the pathogenesis of rheumatoid arthritis. |
| Targets & IC50 | JAK2:22.7 nM |
| In vitro | RAI-20 inhibits the proliferation of Ba/F3 cells with an IC50 of 1.21 μM and suppresses IL-6-induced pSTAT1 expression in human whole blood cells with an IC50 of 1.45 μM. It demonstrates excellent in vitro pharmacokinetic properties, including strong stability in human plasma, moderate metabolism in liver microsomes, high plasma protein binding, no significant CYP inhibition, and hERG inhibition activity with an IC50 of 11.5 μM. |
| In vivo | RAI-20 (2-10 mg/kg; oral administration; daily for 14 days) demonstrates strong, dose-dependent anti-arthritic activity in Lewis rats with collagen-induced arthritis, with the most significant reduction in paw volume and arthritis index observed at a daily dose of 10 mg/kg. |
| Synonyms | H018 |
| Molecular Weight | 448.53 |
| Formula | C20H21FN4O3S2 |
| Cas No. | 2549180-90-5 |
| Smiles | N(C(=O)[C@@H]1[C@@H](F)C1)C2=CN3C(=CC=CC3=N2)C=4SC(CN5CCS(=O)(=O)CC5)=CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: RAI-20 in vivo | RAI-20 in vitro | RAI-20 formula | RAI-20 molecular weight
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