a-33

PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.

NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.

BMY-27709 is an influenza virus growth inhibitor with an IC50 value of 3-8 μM against A WSN 33 virus growth and demonstrates inhibitory activity against certain subtypes of influenza viruses. BMY-27709 acts early in H1 and H2 virus infections by inhibiting hemagglutinin proteins but has no effect on H3 subtype viruses and influenza B Lee 40 viruses.

Compound Fr12413, with CAS No. 18851-33-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr12413 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr12778, with CAS No. 465514-33-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr12778 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr13698, with CAS No. 529-33-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13698 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr14048, with CAS No. 6705-33-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14048 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr14081, with CAS No. 622-33-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14081 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr14184, with CAS No. 13220-33-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14184 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr14304, with CAS No. 5437-33-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14304 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr14309, with CAS No. 369-33-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14309 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr14510, with CAS No. 2713-33-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14510 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr16642, with CAS No. 16874-33-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr16642 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound Fr16720, with CAS No. 108-33-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr16720 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Methyl 4-fluorobenzoate, with CAS No. 403-33-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Methyl 4-fluorobenzoate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Cyclopropylpyridazin-3(2H)-one, with CAS No. 1161737-33-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Cyclopropylpyridazin-3(2H)-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound PDK0406, with CAS No. 930-33-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0406 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.

(+)-JQ-1 (JQ1) is a specific, reversible BET bromine domain inhibitor that targets BRD4 (1/2) with IC50 values of 77/33 nM. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation.

Vortioxetine (Lu AA 21004) is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment.

Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton and acts as an inhibitor of glutamate decarboxylase, with a Ki of 33 μM.

2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)

Compound 2222-33-5, with CAS No. 2222-33-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 2222-33-5 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.