gtp

8-Br-GTP, an analog of GTP, functions as both a competitive inhibitor of FtsZ polymerization and GTPase activity (with a K i value of 31.8 μM). Moreover, it is capable of facilitating nucleic acid modification.

GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).

Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) activates signal-transducing G proteins involved in cellular processes such as proliferation, differentiation, and activation of intracellular kinase cascades. It regulates proliferation and apoptosis through the hydrolysis by small GTPases Ras and Rho, and plays a role in vesicle docking, fusion, and formation via Rab. Additionally, GTP serves as an energy-rich precursor for the biosynthesis of DNA and RNA.

2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis

Guanosine-5'-triphosphate disodium salt (5'-GTP disodium salt) is an enhancer of myogenic cell differentiation and serves as an energy source for translation and other critical cellular processes.

BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.

Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate (sodium) is an isomer of dGTP and functions as an inhibitor of telomerase, with an inhibition constant (Ki) of 15 μM for the human enzyme.

(±)-Decursinol (3',4'-dihydro-3'-hydroxy-Xanthyletin) is a natural product from Angelica gigas.

5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].

2'-O-Methylguanosine-5'-O-triphosphate (2'-methyl GTP) acts as an inhibitor targeting the hepatitis C virus (HCV) non-structural protein 5B (NS5B; with an IC50 of 3.5 µM), and serves as an active metabolite of the prodrug IDX184 through a 2'-methylguanosine intermediate transformation. Additionally, at a concentration of 50 µM, it promotes tubulin polymerization. Notably, levels of 2'-methyl GTP are reduced in the tumoral tissues of patients with hepatocellular carcinoma in comparison to the adjacent normal tissues.

3'-O-Methylguanosine-5'-O-triphosphate (3'-O-methyl GTP), a methylated derivative of GTP, serves as a chain termination reagent in synthesizing early RNA polymerase II elongation intermediates.

KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSC-LC cells with KRAS mutation but not normal lung cells

BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) with IC50 of 46.11 nM. BC-LI-0186 competitively binds the RagD interaction site of LRS with Kd of 42.1 nM and has no effect on LRS-vps34, LRS-eprs, RagB-RagD association, mTORC1 complex formation. BC-LI-0186 potently inhibits the activity of tumor-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 can be used for lung cancer-related research.

2'-O-Benzylguanosine-5'-O-triphosphate (tertsodium) [2'-O-Benzyl gtp (tertsodium)] is a modified nucleotide.

3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.

3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.

6-Thio-GTP (tetrasodium) is an inhibitor of Vav1-Rac. It can suppress TCR-induced T cell proliferation and CD28-mediated T cell survival. In a murine model of allogeneic heart transplantation, 6-Thio-GTP (tetrasodium) demonstrates immunosuppressive effects, which can prolong the survival time of heart transplants.

3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki of 1.5 μM. This compound can be integrated by telomerase into the 3′ end of DNA and has the ability to inhibit telomerase activity in HeLa cells in vitro.

TNP-β-L-GTP tetrasodium is a fluorescent GTP analog utilized in the study of binding kinetics and affinity of GTP-binding proteins, such as G proteins and GTPases. This compound, which carries a TNP fluorescent group, exhibits changes in fluorescence intensity upon protein binding, enabling quantitative analysis.

8-Br-GTP (tetrasodium) [8-Bromoguanosine-5'-triphosphate (tetrasodium)] is a derivative of the energy substrate GTP, utilized in protein synthesis and gluconeogenesis. It inhibits the E. coli GTPase FtsZ with a Ki value of 31.8 μM and promotes the assembly of microtubules in pig brains.

GTP-Binding Protein Fragment, Gs alpha is a polypeptide molecule with the sequence CKQLQKDKQVYRATHR.

3'-Aminoacetyl-GTP sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.

LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.

2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.