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Solid Tumors Target Proteins

Certain research progress has been made in CAR-T in solid tumors, including esophageal cancer, gastric cancer, liver cancer, colorectal cancer, pancreatic cancer, and bile duct cancer. Compared with hematoma, there are many types of solid tumor, various pathogenic mechanisms, difficult target selection, and more scattered targets in research projects. Overall, Mesothelin, HER2, EGFR, GPC3, GD2, CD276, MUC1 and Claudin 18.2 (CLDN18.2) were common targets.

  • Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated
    TMPJ-00155
    Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. MUC-1 can act both as an adhesion and an anti-adhesion protein. This protein may provide a protective layer on epithelial cells against bacterial and enzyme attack. MUC-1 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1 influences directly or indirectly the Ras/MAPK pathway. MUC-1 promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response.
    • $355
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  • EpCAM/TROP1 Protein, Mouse, Recombinant (hFc)
    TMPJ-00200
    Epithelial Cellular Adhesion Molecule (Ep-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the EPCAM family. Its’ monomer subunit structure interacts with phosphorylated CLDN7. Ep-CAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. It also up-regulates the expression of FABP5, MYC and cyclins A and E. The post-translational modification glycosylation at Asn-198 is crucial for protein stability.
    • $60
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  • CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated
    TMPJ-01432
    MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC16-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. MUC16 is also cyclically expressed in the endometrium and may contribute to immune privilege during pregnancy. In the eye, MUC16 and other mucins protect the cornea and keep it hydrated. It is altered on the conjunctival epithelium of patients with non-Sjogren dry eye syndrome.
    • $355
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  • CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
    TMPK-00080
    CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51.8 kDa and the accession number is P32970-1.
    • $814
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  • EpCAM/TROP1 Protein, Human, Recombinant (aa 24-265, hFc)
    TMPK-00206
    Epithelial Cellular Adhesion Molecule (EpCAM), also known as KS1/4, gp40, GA733-2, 17-1A, and TROP‑1, is a 40 kDa transmembrane glycoprotein that consists of a 242 amino acid (aa) extracellular domain with two EGF‑like repeats, a 23 aa transmembrane segment, and a 26 aa cytoplasmic domain. EpCAM/TROP1 Protein, Human, Recombinant (aa 24-265, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 54.2 kDa and the accession number is P16422.
    • $302
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  • ROR2 Protein, Human, Recombinant (hFc)
    TMPK-00579
    ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. Mature human ROR2 contains a 369 amino acid (aa) extracellular domain (ECD) and a 518 aa cytoplasmic tail containing an tyrosine kinase domain. ROR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 68 kDa and the accession number is A1L4F5.
    • $487
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  • CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated
    TMPK-01366
    CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
    • $814
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  • Nectin-4 Protein, Human, Recombinant (His & Avi)
    TMPK-00308
    Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. Nectin-4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 37.2 kDa and the accession number is Q96NY8.
    • $418
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  • B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)
    TMPK-01017
    B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is Q5ZPR3-2.
    • $371
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  • B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
    TMPK-00314
    B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.5 kDa and the accession number is Q5ZPR3-1.
    • $418
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  • EGFRVIII Protein, Human, Recombinant (His & Avi)
    TMPK-00691
    The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.6 kDa and the accession number is NP_001333870.1.
    • $465
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  • HGFR/c-Met Protein, Cynomolgus, Recombinant (His)
    TMPK-00499
    c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.5 kDa (α chain) and 69.9 kDa (β chain) and the accession number is A0A2K5UM36.
    • $487
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  • HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST)
    TMPY-04379
    HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.
    • $498
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  • EpCAM/TROP1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPY-05601
    EpCAM/TROP1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 56 kDa and the accession number is P16422.
    • $462
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  • CD70 Protein, Human, Recombinant (rFc)
    TMPY-04982
    CD70 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 44.6 kDa and the accession number is A0A0U5JA32.
    • $539
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  • CA125/MUC16 Protein, Human, Recombinant (His)
    TMPY-06614
    CA125/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.27 kDa and the accession number is Q8WXI7-1.
    • $600
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  • VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
    TMPY-04802
    VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.4 kDa and the accession number is P35968-1.
    • $1,000
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  • VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-05610
    VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 86.5 kDa and the accession number is P35968-1.
    • $462
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  • EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated
    TMPY-05117
    EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is P16422.
    • $306
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  • EGFR Protein, Cynomolgus, Recombinant (His)
    TMPY-04818
    EGFR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is A0A2K5WK39.
    • $255
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  • EGFR Protein, Human, Recombinant (Isoform Viii, hFc)
    TMPY-05258
    EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1.
    • $398
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  • ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-05603
    ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.2 kDa and the accession number is Q01973.
    • $462
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  • Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His)
    TMPY-06833
    Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.28 kDa and the accession number is P15941-1.
    • $600
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  • HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)
    TMPY-00636
    HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.
    • $386
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  • TROP-2 Protein, Cynomolgus, Rhesus, Recombinant (His)
    TMPY-05153
    TROP-2 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.7 kDa and the accession number is XP_001114599.1.
    • $235
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  • EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated
    TMPY-05612
    EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 71.9 kDa and the accession number is P00533-1.
    • $462
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  • VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
    TMPY-05657
    VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P35968-1.
    • $306
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  • EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-05587
    EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 30.7 kDa and the accession number is P16422.
    • $296
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  • EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant
    TMPY-00534
    EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 28 kDa and the accession number is G7PM59.
    • $600
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  • CD70 Protein, Human, Recombinant (hFc)
    TMPY-01068
    CD70 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.5 kDa and the accession number is A0A0U5JA32.
    • $296
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  • EpCAM/TROP1 Protein, Mouse, Recombinant (His)
    TMPY-01766
    EpCAM/TROP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.1 kDa and the accession number is Q99JW5.
    • $361
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  • HER2/ERBB2 Protein, Rhesus, Recombinant (hFc)
    TMPY-01945
    HER2/ERBB2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.3 kDa and the accession number is XP_001090430.1.
    • $600
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  • NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His)
    TMPY-03256
    NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is P26718-1.
    • $386
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  • EGFR Protein, Mouse, Recombinant (His)
    TMPY-02676
    EGFR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is Q01279.
    • $386
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  • EpCAM/TROP1 Protein, Rat, Recombinant (hFc)
    TMPY-03003
    EpCAM/TROP1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.8 kDa and the accession number is O55159.
    • $600
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  • CD70 Protein, Rat, Recombinant (hFc)
    TMPY-03129
    CD70 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is D3ZGU3.
    • $539
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  • NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His)
    TMPY-03376
    NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.3 kDa and the accession number is P61252.
    • $386
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  • HGFR/c-Met Protein, Canine, Recombinant (His)
    TMPY-02068
    HGFR/c-Met Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is Q75ZY9.
    • $600
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  • EGFR Protein, Mouse, Recombinant (hFc)
    TMPY-02675
    EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.
    • $600
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  • FOLR1 Protein, Canine, Recombinant (hFc)
    TMPY-02417
    FOLR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is A0A8C0Z2T7.
    • $600
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  • EGFR Protein, Rat, Recombinant (His)
    TMPY-02958
    EGFR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is E7CXR8.
    • $600
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  • ROR1 Protein, Human, Recombinant (hFc)
    TMPY-04068
    ROR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69 kDa and the accession number is Q01973.
    • $222
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  • EGFR vIII Protein, Human, Recombinant (His)
    TMPJ-00648
    EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 61-75 Kda and the accession number is NP_001333870.
    • $129
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  • HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated
    TMPJ-00415
    Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both α and β chains of HGF R, mediates both ligand binding and receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
    • $355
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  • CD27 Ligand/CD70 Protein, Mouse, Recombinant (His)
    TMPJ-00075
    CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
    • $86
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  • FOLR1 Protein, Rhesus macaque, Recombinant (His)
    TMPJ-00148
    FOLR1 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-38 kDa and the accession number is F7BP60.
    • $102
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  • VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
    TMPJ-00414
    VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 120-150 KDa and the accession number is P35968.
    • $355
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  • FOLR1 Protein, Human, Recombinant (His & Avi)
    TMPK-00150
    Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
    • $418
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  • HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPJ-00776
    HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 120-140 KDa and the accession number is P04626.
    • $355
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  • NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled
    TMPK-00107
    NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 43.4 kDa and the accession number is P26718.
    • $1,400
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