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Results for "

IFN-��

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    178
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | Compound_Libraries
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    TargetMol | Inhibitors_Agonists
IFN alpha-IFNAR-IN-1 hydrochloride
T116302070014-98-9In house
IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR, effectively inhibiting MVA-induced IFN-α responses by BM-pDCs with an IC50 of 2-8 μM.
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6-8 weeks
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IFN alpha-IFNAR-IN-1
T11630L844882-93-5
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor that disrupts the interaction between IFN-α and IFNAR, inhibiting MVA-induced IFN-α responses by BM-pDCs (IC50: 2-8 μM).
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6-8 weeks
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StA-IFN-1
T38158300839-31-0
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
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6-8 weeks
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IFN-γ Antagonist 1
T76637158040-83-6
IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI), an interferon γ (IFN γ) antagonist, effectively inhibits IFN-γ induced HLR DR antigen expression in Colon 205 cells, demonstrating an IC50 of approximately 35 μM. This compound shows promise for applications in immune regulation [1].
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IFN-γ Antagonist 1 acetate
T76638
IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) acetate, an interferon γ (IFN γ) antagonist, effectively inhibits the expression of HLR DR antigen in Colon 205 cells induced by IFN-γ, with an IC50 of approximately 35 μM. This compound holds promise for applications in immune regulation [1].
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Anti-Mouse IFN gamma Antibody (H22)
T78262
Anti-Mouse IFN Gamma Antibody is a host Armenian Hamster-derived anti-mouse IFN gamma immunoglobulin G (IgG) inhibitor.
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2-4 weeks
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Anti-Mouse IFN gamma Antibody (XMG1.2)
T9901A-111
Anti-Mouse IFN gamma Antibody (XMG1.2) is a rat IgG1 kappa monoclonal antibody specifically targeting IFNγ in mice. The recommended isotype control for this antibody is Rat IgG1 kappa, Isotype Control.
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2-4 weeks
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Anti-Mouse IFN gamma Antibody (R4-6A2)
T9901A-175
Anti-Mouse IFN gamma Antibody (R4-6A2) is a rat-derived IgG1 kappa isotype antibody designed for in vivo targeting of mouse IFNγ. The recommended isotype control for this antibody is Rat IgG1 kappa, Isotype Control.
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IFN-α Receptor Recognition Peptide 1
IRRP1
TP1117153840-64-3
IFN-α Receptor Recognition Peptide 1, associated with receptor interactions, is a peptide of IFN-α.
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TargetMol
2',3'-cGAMP sodium
2'-3'-cyclic GMP-AMP sodium
T10065L2734858-36-5In house
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.
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TargetMol | Inhibitor Hot
Deucravacitinib
BMS-986165
T146871609392-27-9
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor for the treatment of autoimmune diseases. It blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain, inhibiting IL-12 23 and type I IFN pathways. It selectively binds to the TYK2 pseudokinase (JH2) domain with an IC50 of 1.0 nM.
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TargetMol | Inhibitor Hot
2-(1,8-naphthyridin-2-yl)phenol
T216865182-56-1
2-NP is a STAT1 enhancer.
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TargetMol | Inhibitor Hot
Vadimezan
NSC 640488, DMXAA, ASA-404, 5,6-Dimethylxanthenone-4-acetic Acid
T6273117570-53-3
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.
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TargetMol | Inhibitor Hot
(R)-Lisofylline
(R)-Lisophylline
T21694100324-81-0In house
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM) that interrupts IL-12 signaling-mediated STAT4 activation, making it useful for studies on the treatment of type 1 diabetes and autoimmune disorders.
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3-Hydroxykynurenamine
T6818299362-47-7In house
3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1 NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring, reducing TNF, IL-1β, IFN-γ, and IL-17 production, and inhibiting generation of effector CD8+ T cells. Similarly, in a mouse model of nephrotoxic nephritis, besides reducing inflammatory cytokines, 3-HKA improves proteinuria and serum urea nitrogen, overall ameliorating immune-mediated glomerulonephritis and renal dysfunction.This compound is unstable in powder form and other related salt forms are recommended.
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3-6 months
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Bufexamac
Bufexamic acid
T08672438-72-4
Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
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Hydrocortisone
Cortisol
T161450-23-7
Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilization, and renal calcium excretion, as well as suppressing immune and inflammatory responses.
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(E)-Ferulic acid methyl ester
Methyl ferulate, Methyl (E)-ferulate
T3S000622329-76-6
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a potential inhibitor of the mitogen-activated phosphor kinase pathway and an anti-inflammatory agent first isolated from the medicinal plant S. tuberosa. Additionally, it shows promising anthelmintic activity against Haemonchus contortus.
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TargetMol | Inhibitor Sale
CCCP
Carbonyl Cyanide m-Chlorophenylhydrazone, Carbonyl cyanide 3-chlorophenylhydrazone
T7081555-60-2
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
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TargetMol
MG-T-19
MGT-19, MG T19
T201721328540-44-9
MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells.
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10-14 weeks
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2',3'-cGAMP
2'-3'-cyclic GMP-AMP
T100651441190-66-4
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.
    7-10 days
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    GW9508
    GW 9508
    T1781885101-89-3
    GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
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    RO8191
    RO4948191, CDM-3008
    T22142691868-88-9
    RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
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    TargetMol | Inhibitor Sale
    Ginsenoside F3
    T382962025-50-7
    Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1, type 2 cytokines in murine spleen cells. Ginsenoside-F3 enhances the NF-kappaB DNA binding activity induced by ConA in murine spleen cells (10 μM).
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