hdac1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39567	HDAC1/2-IN-3	HDAC1/2-IN-3
	HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.
T11625	IDO1 and HDAC1 Inhibitor		Others
	IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).		Others
T61433	HDAC1-IN-5
	HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 an...
T62786	HDAC1-IN-3
	HDAC1-IN-3 is a potent inhibitor of Pf HDAC1. HDAC1-IN-3 is antimalarial in both wild-type and multidrug-resistant strains of the parasite. HDAC1-IN-3 exhibits a significant in vivo killing effect on all life cycles of t...
T63482	HDAC1-IN-4
	HDAC1-IN-4 is a potent inhibitor of Plasmodium falciparum HDAC1 (PfHDAC1) with low cytotoxicity and antimalarial effects (IC50<5 nM).
T80873	VEGFR2/HDAC1-IN-1		VEGFR
	VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC. It arrests the cell cycle at the S and G2 phases and induces apoptosis in H...		VEGFR
T82227	HDAC1/CDK7-IN-1		HDAC
	HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effectively suppresses the proliferation of various cancer cell...		HDAC
T64187	HDAC1/6-IN-1
	HDAC1/6-IN-1 is a potent multi-target inhibitor of GLP (IC50: 1.3 nM), HDAC6 (IC50: 13 nM) and HDAC1 (IC50: 89 nM). HDAC1/6-IN-1 inhibits the methylation and deacetylation of H3K9 at the protein level. HDAC1/6-IN-1 can b...
T60947	HDAC1/MAO-B-IN-1
	HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-...
T63209	HDAC1/2 and CDK2-IN-1
	HDAC1/2 and CDK2-IN-1 (compound 14d) are potent inhibitors of HDAC1, HDAC2 and CDK2 with IC50 values of 70.7, 23.1 and 0.80 μM, respectively. HDAC1/2 and CDK2-IN-1 are able to block the cell cycle and induce apoptosis. T...
T7664	Pyroxamide		Apoptosis , HDAC
	Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).		Apoptosis , HDAC
T5347	CXD101	CXD-101	HDAC
	CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II		HDAC
T60794	HDAC10-IN-1
	HDAC10-IN-1 (compound 13b) is a potent and highly selective inhibitor of HDAC10 (IC 50 = 58 nM) that regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1].
T60760	HDAC10-IN-2
	HDAC10-IN-2 (compound 10c) regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells. HDAC10-IN-2 is a potent and highly selective inhibitor of HDAC10 (IC50 = 20 nM) [1].
T78145	HDAC10-IN-2 hydrochloride		Autophagy
	HDAC10-IN-2 hydrochloride (compound 10c) is an HDAC10 inhibitor with high potency and selectivity, exhibiting an IC50 of 20 nM. It influences autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1].		Autophagy
T10603	BRD-6929		HIV Protease , HDAC
	BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) [2]. BRD-6929 potentiates the efficacy of gnidimacrin...		HIV Protease , HDAC
T10245	ACY-957	HDAC Inhibitor C001	HDAC
	ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.		HDAC
T7064	Valproic Acid	Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid	Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
T3516	EDO-S101	Tinostamustine,Minomustine	HDAC
	EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.		HDAC
T6639	RG2833	RGFP109	HDAC
	RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.		HDAC