at1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5439	BRD4 degrader AT1		Epigenetic Reader Domain
	BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.		Epigenetic Reader Domain
T2531	Eprosartan Mesylate	SKF-108566J	RAAS
	Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker.		RAAS
T7838	Losartan Carboxaldehyde		COX
	Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.		COX
T1461	Candesartan	CV 11974	RAAS
	Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.		RAAS
T19840	GSK-F1	PI4KA inhibitor-F1	PI4K
	GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.		PI4K
T1615	Irbesartan	SR-47436,BMS-186295	Apoptosis , RAAS
	Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.		Apoptosis , RAAS
T27404	GAT107	GAT 107,GAT-107	AChR
	GAT107 is a novel and potent α7 nicotinic cholinergic receptor modifier agonist and modulator with anti-inflammatory activity that reverses injury perception in a mouse model of neuropathic pain.		AChR
T16007	MALAT1-IN-1		Others
	MALAT1-IN-1 modulated Malat1 downstream genes in a dose-dependent manner without affecting the expression of nuclear enriched abundant transcript 1 (Neat1). MALAT1-IN-1 is an effective and specific Malat1 inhibitor.		Others
T11820	LAT1-IN-1	BCH	Apoptosis , Others
	LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral...		Apoptosis , Others
T15109	DGAT1-IN-1		Transferase
	DGAT1-IN-1 is a potent inhibitor of diacylglycerol O- acyltransferase type 1(DGAT1, IC50 of < 10 nM).		Transferase
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T77517	URAT1 inhibitor 7		OAT
	URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemi...		OAT
T13259	URAT1 inhibitor 1		OAT
	URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.		OAT
T79177	URAT1&XO inhibitor 2		Xanthine Oxidase
	Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in H...		Xanthine Oxidase
T79114	URAT1 inhibitor 5
	URAT1 Inhibitor 5 (compound 16) serves as a powerful inhibitor of URAT1 and is utilized in hyperuricemia research [1].
T78195	URAT1 inhibitor 8
	URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM. It is applicable in the study of gout [1].
T70301	GAT100
	GAT100 is a potent and covalent negative allosteric modulator (NAM). GAT-100 behaved as a robust positive allosteric modulator of binding of orthosteric agonist CP55,940. This novel covalent probe can serve as a useful ...
T62220	DGAT1-IN-3
	DGAT1-IN-3 is a selective, potent, orally active DGAT-1 inhibitor that inhibits human DGAT-1 (IC50: 38 nM) and rat DGAT-1 (IC50: 120 nM).DGAT1-IN-3 can be used in studies of obesity, dyslipidemia and metabolic syndrome.
T62825	URAT1 inhibitor 2
	URAT1 inhibitor 2 is an orally active inhibitor of URAT1 and CYP isozyme with IC50 values of 1.36 μM, 16.97 μM and 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively, URAT1 inhibitor 2 is a promisi...
T60724	URAT1 inhibitor 3
	URAT1 inhibitor 3 is a potent, orally active, selective inhibitor of URAT1(IC 50 = 0.8 nM). URAT1 inhibitor 3 shows urate-lowering efficacy that can be used in gout and hyperuricemi research [1].