thp

Pirarubicin (Theprubicin) is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as an antineoplastic agent.

MS-PEG4-THP is a PROTAC linker, which is a PEG type.

THP-PEG3-OH is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

THP-PEG4-OH is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

THP-PEG5-OH is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

THP-PEG6-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized in the synthesis of PROTACs[1]. It is also a non-cleavable three-unit PEG linker for antibody-drug conjugates (ADCs)[2].

THP-PEG8-OH is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

THP-PEG8-Tos is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

THP-SS-alcohol is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

THP-SS-PEG1-Boc, a cleavable ADC linker with a one-unit PEG, is commonly used in the synthesis of antibody-drug conjugates (ADCs)[1].

THP-SS-PEG1-Tos is a cleavable 1-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

THP-PEG11-OH is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the selective protein degradation process through the ubiquitin-proteasome system within cells.

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in synthesizing PROTAC K-Ras Degrader-1, as documented in reference [1].

THP-PEG4-Pyrrolidine(N-Me)-CH2OH, a PEG-based PROTAC linker, aids in the synthesis of PROTAC K-Ras Degrader-1[1].

Tos-PEG4-THP is a polyethylene glycol (PEG) derivative utilized as a linker in the synthesis of PROTAC K-Ras Degrader-1, a potential therapeutic compound for targeted degradation of K-Ras protein [1].

Compound 12k (THP-1/MV-4-11 against-1) is a 5-substituted thiazolyl urea anticancer agent with significant inhibitory efficacy against THP-1/MV-4-11 cancer cells, demonstrating IC50 values of 29 nM and 98 nM, respectively.

Benzyl-PEG13-THP is a PROTAC linker, classified under the PEG category, and is used for the synthesis of PROTAC molecules.

THP-PEG11-THP is a PROTAC linker classified under the PEG category and is utilized in the synthesis of PROTAC molecules.

Azido-PEG8-THP is a PROTAC linker classified under the PEG family, utilized in the synthesis of PROTAC molecules. This compound serves as a click chemistry reagent and contains an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

THP-PEG16-alcohol is a type of PROTAC linker classified under the PEG category, and it is suitable for synthesizing PROTAC molecules.

THP-PEG8-THP is a PROTAC linker in the PEG class and is utilized in the synthesis of PROTAC molecules.

THP-PEG16-THP is a PEG-based PROTAC linker used in the synthesis of PROTAC molecules.

THP-PEG12-alcohol is a PROTAC linker belonging to the PEG category, used for synthesizing PROTAC molecules.

THP-PEG4-C1-OH is a PROTAC linker classified under the PEG category, suitable for synthesizing PROTAC molecules.