abc

ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression,and is orally active.

ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.

ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than 25 μM for the inhibition of 9-PAHSA but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260.

ABC294735 is a dual SK1/SK2 inhibitor with potential anticancer activity.

Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).

Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity

Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.

Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.

Mepazine (Pecazine) is a potent and selective inhibitor of MALT1, inhibiting GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM, respectively. Mepazine enhances apoptosis and impacts cell viability.

G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide. G907 inhibits E. coli MsbA with an IC50 value of 18 nM.

Nestifylline is a biochemical.

IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.

M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.

Lanatoside is an FDA-approved cardiac glycoside that has been identified as a candidate anti-dengue compound. It has also been found to promote atherosclerosis. It also has anti-tumor activity, inhibiting the growth of colorectal cancer cells and liver cancer cells.

ABC47 is a potent inhibitor of serine hydrolases, exhibiting IC50 values of 0.03 μM for ABHD4 and 0.1 μM for ABHD3. It plays a crucial role in research on infantile neuronal ceroid lipofuscinosis.

ABC44 is a potent inhibitor of serine hydrolase with IC50s of 0.1 μM and 6.5 μM for palmitoyl protein thioesterase 1 (PPT1) in situ and in vitro, respectively. ABC44 can be used to study late infantile neuron-like lipofuscinosis.

Sabcomeline HCl is an M1 receptor agonist that can be used to study Alzheimer's disease.

(Rac)-Sabcomeline ((Rac)-SB-202026) is an M1/M4 muscarinic agonist used in the study of neurologic disorders such as schizophrenia.

Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for antibody-drug conjugates (ADCs), combining the ADC linker (Acetylene-linker-Val-Cit-PABC) with the potent tubulin inhibitor MMAE.

AcLys-PABC-VC-Aur0101 is a drug-linker conjugate for anti-CXCR4 ADC, exhibiting potent antitumor activity and comprising the auristatin microtubule inhibitor Aur0101, connected through the cleavable linker AcLys-PABC-VC[1].

BCN-PEG1-Val-Cit-PABC-OH is a cleavable 1-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-Val-Cit-PABC-OH, a cleavable linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1].

DBCO-Val-Cit-PABC-PNP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADC) [1].

Fmoc-Ala-Ala-Asn-PABC-PNP is a cleavable peptide ADC linker [1].