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Search Results for " a549 "

Targets

193

Compounds

98

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2430 HPOB Apoptosis , HDAC
HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
T6455 CP-91149 Phosphorylase
CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.
T8466 BC-DXI-843 Others
BC-DXI-843 is inhibitor of AIMP2-DX2, and is potential for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.
T15411 GPNA hydrochloride Apoptosis , Others
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT)....
T9119 SU0268 Others
SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
T11631 IFSP1 Ferroptosis
iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3.iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP...
T60028 MM41 DNA/RNA Synthesis
MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.
T8793 CBS1117 Influenza Virus
CBS1117 is a virus entry inhibitor (IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1)). It interferes with the hemagglutinin (HA)-mediated fusion process.
T50005 Sertaconazole Antifungal
Sertaconazole is a broad-spectrum antifungal.
T7856 Naphthol AS-E nAS-E Epigenetic Reader Domain , Histone Acetyltransferase
Naphthol AS-E (nAS-E) is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T8317 5'-Fluoroindirubinoxime 5'-FIO FLT
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).
T16961 Supinoxin RX-5902 Apoptosis , DNA/RNA Synthesis
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...
T7122 AZD-7648 DNA-PK
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
T9098 DMG-PEG 2000 DMG-PEG2000 Others
DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid...
T0239 Lonidamine AF1890,DICA,Diclondazolic Acid Apoptosis , Hexokinase , Mitochondrial Metabolism
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
T12854 SBI-797812 NAMPT
SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).
T9891 PARP1-IN-8  N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide PARP
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).
T6665 Sertaconazole nitrate FI-7045,Ginedermofix,FI7056,Ertaczo Antibiotic , Antifungal
Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections.
T20168 Aurothiomalate sodium Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate Others , PKC
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ...
T1083L Theophylline monohydrate Quibron HDAC , PDE , Adenosine Receptor
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ...
T9533 BC-LI-0186 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide Others
BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protei...
T5135 Flupentixol dihydrochloride Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride Dopamine Receptor
Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.
T9105 NF-κB-IN-1 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- IκB/IKK , NF-κB
NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir...
T5858 Sertindole Lu 23-174 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T12344L1 OTS186935 FA OTS186935 FA(2093400-18-9 Free base) Histone Methyltransferase
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
T8979 AEM1 Nrf2
AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibit...
T62281 PARP-1-IN-2 PARP
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel...
T77728 Tubulin polymerization-IN-55 Microtubule Associated
Tubulin polymerization-IN-55 is a potent Tubulin Polymerization inhibitor with potential anti-angiogenic and anti-tumour activity, showing anti-proliferative effects against A549, K562, HepG2, MDA-MB-231 and HFL-1.
T15451 GW-870086 Glucocorticoid Receptor
GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB).
T8967 SW155246 DNA Methyltransferase
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
T77734 ERK5-IN-5 ERK
ERK5-IN-5 is a potent extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity and potential anticonvulsant activity that inhibits A549 cell proliferation.
T1887 Inauhzin INZ Sirtuin
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54...
T60675L AMPK activator 2 hydrochloride( 2410961-69-0 Free base) AMPK activator 2 hydrochloride( 2410961-69-0 Free base) AMPK
AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK activator 2 hydrochloride inhibits the proliferation and mi...
T36316 MTOR inhibitor-8 mTOR-IN-8 mTOR , Autophagy
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.
T22317 DRB18 transporter
DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associate...
T8816 NAE-IN-M22 NEDD8 inhibitor M22 Apoptosis , E1/E2/E3 Enzyme
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i...
T22396 PF-6274484 PF 6274484 EGFR
PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and ...
T7018 WZB117 transporter
WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells proliferation.
T63343 ULK1-IN-2 Apoptosis , Autophagy
ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells....
T4335 GNE-617 GNE617 NAMPT
GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.
T7082 HDAC8-IN-1 HDAC
MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ...
T36493 CMLD-2 Apoptosis , HuR
CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor ef...
T19661 8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258 AMPK
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch...
T20882 4-Nitrobenzoic acid Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid
4-Nitrobenzoic acid (4Nitrobenzoic acid) is a pharmaceutical intermediate often found in the production of folic acid, DABA, PABA and dyes.
T9582 CLEFMA NF-κB
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
T35610 2,5-dimethyl Celecoxib Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ...
T74400 TC113
TC113 is a c(RGDyK)-Based conjugate of Gemcitabine (GEM). TC113 could be internalized by A549 cells through integrin α v β 3 . TC113 shows potent antiproliferative properties against WM266.4 and A549 cells [1] .
T78941 Anticancer agent 130 Apoptosis
Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].
T63590 C-Met-IN-10
c-Met-IN-10 is a potent c-Met kinase inhibitor (IC50: 16 nM). c-Met-IN-10 inhibits the activity of cancer cells A549, H460 and HT-29, and inhibits A549 cell movement by inhibiting HT-29 cell colony formation, which in tu...
T11421 Glutaminase-IN-1 CB839 derivative transporter
Glutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine renal-type glutaminase (KGA) variant inhibitor, showed antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.

Compounds

HPOB
T2430
Synonym:
Target: Apoptosis, HDAC
CP-91149
T6455
Synonym:
Target: Phosphorylase
BC-DXI-843
T8466
Synonym:
Target: Others
GPNA hydrochloride
T15411
Synonym:
Target: Apoptosis, Others
SU0268
T9119
Synonym:
Target: Others
iFSP1
T11631
Synonym:
Target: Ferroptosis
MM41
T60028
Synonym:
Target: DNA/RNA Synthesis
CBS1117
T8793
Synonym:
Target: Influenza Virus
Sertaconazole
T50005
Synonym:
Target: Antifungal
Naphthol AS-E
T7856
Synonym: nAS-E
Target: Epigenetic Reader Domain, Histone Acetyltransferase
5'-Fluoroindirubinoxime
T8317
Synonym: 5'-FIO
Target: FLT
Supinoxin
T16961
Synonym: RX-5902
Target: Apoptosis, DNA/RNA Synthesis
AZD-7648
T7122
Synonym:
Target: DNA-PK
DMG-PEG 2000
T9098
Synonym: DMG-PEG2000
Target: Others
Lonidamine
T0239
Synonym: AF1890,DICA,Diclondazolic Acid
Target: Apoptosis, Hexokinase, Mitochondrial Metabolism
SBI-797812
T12854
Synonym:
Target: NAMPT
PARP1-IN-8 
T9891
Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide
Target: PARP
Sertaconazole nitrate
T6665
Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo
Target: Antibiotic, Antifungal
Aurothiomalate sodium
T20168
Synonym: Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate
Target: Others, PKC
Theophylline monohydrate
T1083L
Synonym: Quibron
Target: HDAC, PDE, Adenosine Receptor
BC-LI-0186
T9533
Synonym: 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide
Target: Others
Flupentixol dihydrochloride
T5135
Synonym: Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride
Target: Dopamine Receptor
NF-κB-IN-1
T9105
Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
Target: IκB/IKK, NF-κB
Sertindole
T5858
Synonym: Lu 23-174
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy
OTS186935 FA
T12344L1
Synonym: OTS186935 FA(2093400-18-9 Free base)
Target: Histone Methyltransferase
AEM1
T8979
Synonym:
Target: Nrf2
PARP-1-IN-2
T62281
Synonym:
Target: PARP
Tubulin polymerization-IN-55
T77728
Synonym:
Target: Microtubule Associated
GW-870086
T15451
Synonym:
Target: Glucocorticoid Receptor
SW155246
T8967
Synonym:
Target: DNA Methyltransferase
ERK5-IN-5
T77734
Synonym:
Target: ERK
Inauhzin
T1887
Synonym: INZ
Target: Sirtuin
AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
T60675L
Synonym: AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
Target: AMPK
mTOR inhibitor-8
T36316
Synonym: mTOR-IN-8
Target: mTOR, Autophagy
DRB18
T22317
Synonym:
Target: transporter
NAE-IN-M22
T8816
Synonym: NEDD8 inhibitor M22
Target: Apoptosis, E1/E2/E3 Enzyme
PF-6274484
T22396
Synonym: PF 6274484
Target: EGFR
WZB117
T7018
Synonym:
Target: transporter
ULK1-IN-2
T63343
Synonym:
Target: Apoptosis, Autophagy
GNE-617
T4335
Synonym: GNE617
Target: NAMPT
HDAC8-IN-1
T7082
Synonym:
Target: HDAC
CMLD-2
T36493
Synonym:
Target: Apoptosis, HuR
8-Chloroadenosine
T19661
Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258
Target: AMPK
4-Nitrobenzoic acid
T20882
Synonym: Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid
Target:
CLEFMA
T9582
Synonym:
Target: NF-κB
2,5-dimethyl Celecoxib
T35610
Synonym:
Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor
TC113
T74400
Synonym:
Target:
Anticancer agent 130
T78941
Synonym:
Target: Apoptosis
c-Met-IN-10
T63590
Synonym:
Target:
Glutaminase-IN-1
T11421
Synonym: CB839 derivative
Target: transporter
1 2 3 4
Cat No. Product Name Synonyms Targets
T3870 Cyasterone Cyasteron Apoptosis , EGFR
Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.
T5739 Paederosidic acid Apoptosis , BCL
Paederosidic acid has significant anti-tumor, anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain, and it up-regulates expressions of GA...
T5758 Sphondin COX , Prostaglandin Receptor
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
T1083 Theophylline Theo-24,1,3-Dimethylxanthine Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T5S0106 Peimisine Ebeiensine RAAS , AChR
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe...
T3981 Acacetin 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin Apoptosis , IAP , COX , Autophagy
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
T1205 Chloramphenicol Chlornitromycin,Levomycetin,Chloromycetin ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T2870 Matrine Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T6290 Tanespimycin 17-AAG,CP 127374,NSC 330507,KOS 953 Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy
Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T2S0618 β-Elemonic Acid 3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid Apoptosis , Reactive Oxygen Species , COX
β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are rel...
T3008 Lawsone methyl ether 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone Apoptosis , Antibacterial , Antifungal
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s...
T2S1593 Gypenoside XLVI Others
Gypenoside XLVI shows strong cytotoxic activity against A549 cells, with the IC50 values of 52.63±8.31 ug/ml.
T4S1540 Myrislignan Apoptosis , NF-κB
Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induc...
T6S0077 Byakangelicol COX
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...
TN1727 Helichrysetin Apoptosis , HIV Protease
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.
T3771 Methyl protodioscin Smilax saponin B,NSC-698790 Apoptosis
Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h...
TN1721 Gypenoside L ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a...
T5S1607 Morusin Mulberrochromene NF-κB , Antibacterial , STAT
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti...
T7027 EURYCOMANONE Pasakbumin A Others
Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...
TN2755 2-Desoxy-4-epi-pulchellin Anti-infection
2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...
T3404 Cucurbitacin B Cuc B,DATISCACIN,Amarine Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...
TN1516 Cnidicin NOS , NO Synthase
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the pr...
TN3972 Epimedokoreanin B Apoptosis , Others , Antibacterial
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-...
TN1003 DL-Alanine DL-2-Aminopropionic acid Endogenous Metabolite
DL-Alanine (DL-2-Aminopropionic acid) is an amino acid that is a racemic compound of L- and D-alanine.DL-Alanine is often used as a reducing and capping agent in conjunction with aqueous silver nitrate for nanoparticle g...
T2973 Astragaloside IV AST-IV,AS-IV MMP , ERK , Estrogen/progestogen Receptor , JNK
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...
TN5538 6-Methoxykaempferol Others
6-Methoxykaempferol is a flavonoid found in brazilian propolis. 6-Methoxykaempferol has anti-proliferative activity against cancer cells, neuroprotective effects on isolated rat brain synaptosomes and reduces glutathione...
TN2666 1alpha-Hydroxytorilin Others
1alpha-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
TN5287 3β,5α-Dihydroxyergosta-7,22-dien-6-one
3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), res...
TN3832 Deoxyflindissone Others
Deoxyflindissone exhibits significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines.
TN2273 Tigloylgomisin P Others
Tigloylgomisin P shows moderate to marginal cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines.
TN2590 11alpha,12alpha-Oxidotaraxerol palmitate Others
11alpha,12alpha-Oxidotaraxerol palmitate shows selective cytotoxicity against HCT-8, Bel-7402, BGC-823, A549 and A2780.
TN2114 Pseudoginsenoside Rh2 ERK , Raf , p53
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenosid...
T20749 Bisabolene Bisabolene (natural),FEMA 3331,Limene Others
Bisabolene (FEMA 3331) is a sesquiterpene extracted from oregano and other aromatic plants. It is a potential anticancer agent and studies have shown that it can induce apoptosis in the A549 cancer cell line.
T82344 Gambogic acid B
Gambogic acid B, isolated from Garcinia hanburyi resin, exhibits cytotoxic effects on A549, HCT116, and MDA-MB-231 cell lines with respective IC50 values of 1.60 µM, 6.88 µM, and 0.87 µM [1].
TN5579 Trigoxyphin A
Trigoxyphin A exhibits strong cytotoxic activity against HL60 (IC(50): 0.27 microM) and A549 (IC(50): 7.5 microM) tumor cell lines.
TN5373 Ustusolate A
1. Ustusolate A shows weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.
TN5574 Heudelotinone
Heudelotinone shows cytotoxicity against three cancer cell lines A549, Hela, and SMMC-7721( IC50 values of 16.04, 10.67 and 21.68 uM , respectively).
TN5274 Yunnancoronarin A Others
Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.
TN3429 Aphagranin A Others
Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.
T75451 Cytoglobosin C
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC 50 <10 μM) [1] .
T83481 1,1′-Disinomenine
1,1′-Disinomenine, an alkaloid extracted from the stems of Sinomenium acutum, exhibits modest inhibitory activity against A549 and Hela cells [1].
TN4177 Gypenoside LI Others
Gypenoside LI possesses non-small cell lung carcinoma A549 cell inhibitory activity.
TN5879 Edgeworin
Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A...
TN3617 Cedrelopsin Others
Cedrelopsin shows significant inhibition against A549 cells with IC50 values of 3.6-5.9 ug/mL.
T13629 Cyclo(Ala-Gly) Others
Cyclo (Ala-Gly) is a mangrove endophytic fungus, a metabolite of Penicillium thomi, which is cytotoxic to A549, HepG2 and HT29 cells. The IC50 value is in the range of 9.5-18.1 μM.
TN4356 Jolkinolide A Akt , STAT , mTOR
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs.
TN3250 7-Prenyljacareubin Others
7-Prenyljacareubin shows moderate cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.
TN3445 Aristolactam BIII PAFR
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.
T83366 3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone
3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone, a natural product isolated from the fruits of Vitex rotundifolia, exhibits potent cytotoxic activity against A549 and HepG-2 cell lines [1].
T82429 Euphoheliosnoid A
Euphoheliosnoid A (Compound 24), a diterpenoid, significantly enhances natural killer (NK) cell-mediated cytotoxicity against H1299-luci cells and A549-luci cells at a concentration of 2.5 μM [1].
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Natural Products

Cyasterone
T3870
Synonym: Cyasteron
Target: Apoptosis, EGFR
Paederosidic acid
T5739
Synonym:
Target: Apoptosis, BCL
sphondin
T5758
Synonym:
Target: COX, Prostaglandin Receptor
Theophylline
T1083
Synonym: Theo-24,1,3-Dimethylxanthine
Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy
Peimisine
T5S0106
Synonym: Ebeiensine
Target: RAAS, AChR
Acacetin
T3981
Synonym: 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin
Target: Apoptosis, IAP, COX, Autophagy
Chloramphenicol
T1205
Synonym: Chlornitromycin,Levomycetin,Chloromycetin
Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
Matrine
T2870
Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine
Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy
Tanespimycin
T6290
Synonym: 17-AAG,CP 127374,NSC 330507,KOS 953
Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy
β-Elemonic Acid
T2S0618
Synonym: 3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid
Target: Apoptosis, Reactive Oxygen Species, COX
Lawsone methyl ether
T3008
Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone
Target: Apoptosis, Antibacterial, Antifungal
Gypenoside XLVI
T2S1593
Synonym:
Target: Others
Myrislignan
T4S1540
Synonym:
Target: Apoptosis, NF-κB
Byakangelicol
T6S0077
Synonym:
Target: COX
Helichrysetin
TN1727
Synonym:
Target: Apoptosis, HIV Protease
Methyl protodioscin
T3771
Synonym: Smilax saponin B,NSC-698790
Target: Apoptosis
Gypenoside L
TN1721
Synonym:
Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS
Morusin
T5S1607
Synonym: Mulberrochromene
Target: NF-κB, Antibacterial, STAT
EURYCOMANONE
T7027
Synonym: Pasakbumin A
Target: Others
2-Desoxy-4-epi-pulchellin
TN2755
Synonym:
Target: Anti-infection
Cucurbitacin B
T3404
Synonym: Cuc B,DATISCACIN,Amarine
Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy
Cnidicin
TN1516
Synonym:
Target: NOS, NO Synthase
Epimedokoreanin B
TN3972
Synonym:
Target: Apoptosis, Others, Antibacterial
DL-Alanine
TN1003
Synonym: DL-2-Aminopropionic acid
Target: Endogenous Metabolite
Astragaloside IV
T2973
Synonym: AST-IV,AS-IV
Target: MMP, ERK, Estrogen/progestogen Receptor, JNK
6-Methoxykaempferol
TN5538
Synonym:
Target: Others
1alpha-Hydroxytorilin
TN2666
Synonym:
Target: Others
3β,5α-Dihydroxyergosta-7,22-dien-6-one
TN5287
Synonym:
Target:
Deoxyflindissone
TN3832
Synonym:
Target: Others
Tigloylgomisin P
TN2273
Synonym:
Target: Others
11alpha,12alpha-Oxidotaraxerol palmitate
TN2590
Synonym:
Target: Others
Pseudoginsenoside Rh2
TN2114
Synonym:
Target: ERK, Raf, p53
Bisabolene
T20749
Synonym: Bisabolene (natural),FEMA 3331,Limene
Target: Others
Gambogic acid B
T82344
Synonym:
Target:
Trigoxyphin A
TN5579
Synonym:
Target:
Ustusolate A
TN5373
Synonym:
Target:
Heudelotinone
TN5574
Synonym:
Target:
Yunnancoronarin A
TN5274
Synonym:
Target: Others
Aphagranin A
TN3429
Synonym:
Target: Others
Cytoglobosin C
T75451
Synonym:
Target:
1,1′-Disinomenine
T83481
Synonym:
Target:
Gypenoside LI
TN4177
Synonym:
Target: Others
Edgeworin
TN5879
Synonym:
Target:
Cedrelopsin
TN3617
Synonym:
Target: Others
Cyclo(Ala-Gly)
T13629
Synonym:
Target: Others
Jolkinolide A
TN4356
Synonym:
Target: Akt, STAT, mTOR
7-Prenyljacareubin
TN3250
Synonym:
Target: Others
Aristolactam BIII
TN3445
Synonym:
Target: PAFR
3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone
T83366
Synonym:
Target:
Euphoheliosnoid A
T82429
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00305 TGFBR1 Protein, Human, Recombinant (mFc & Avi) Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPK-00306 TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TargetMol