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TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79603 3,7-DMF 20950-52-1 98%
3,7-DMF
3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By indu...
T79789 DT-6 2414315-95-8 98%
DT-6
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing p...
T80562 Nisevokitug 2649854-92-0 98%
Nisevokitug
Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1].
T80628 Myristoyl tetrapeptide-12 959610-24-3 98%
Myristoyl tetrapeptide-12
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].
T12923 (Rac)-SIS3 free base 1009104-85-1 98%
(Rac)-SIS3 free base
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
T61389 TGFβ1-IN-1 2348795-14-0 98%
TGFβ1-IN-1
TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the s...
TN3753 Dalbergioidin 30368-42-4 98%
Dalbergioidin
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
T13137 TGFβRI-IN-1 1950628-94-0 98%
TGFβRI-IN-1
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
T76774 Ponsegromab 2368950-15-4 SDS-PAGE:95% SEC-HPLC:99.99%
Ponsegromab
Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor. Ponsegromab has anti-cachexic activity by binding to GDF15 to pre...
T76858 Ascrinvacumab 1463459-96-2 SDS-PAGE:95% SEC-HPLC:98.18%
Ascrinvacumab
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has ...
T76681 Fresolimumab 948564-73-6 SDS-PAGE:95% SEC-HPLC:95%
Fresolimumab
Fresolimumab (GC1008) is a specific human anti-transforming growth factor β monoclonal antibody that binds to the active forms of human TGFβ1, TGFβ2, and TGFβ3 a...
T76941 Carotuximab 1268714-50-6 SDS-PAGE:95% SEC-HPLC:95%
Carotuximab
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD10...
T77019 Garetosmab 2097125-54-5 SDS-PAGE:95% SEC-HPLC:95%
Garetosmab
Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cance...
T3674 Hydroxysafflor yellow A 78281-02-4 99.99%
Hydroxysafflor yellow A
Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver fro...
T2386 Pirfenidone 53179-13-8 99.93%
Pirfenidone
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, ...
TN2165 Rubrofusarin gentiobioside 24577-90-0 99.91%
Rubrofusarin gentiobioside
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA bindi...
T2896 Alantolactone 546-43-0 99.91%
Alantolactone
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th...
T2273 ITD-1 1099644-42-4 99.89%
ITD-1
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
T1726 SB-431542 301836-41-9 99.87%
SB-431542
SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other...
T2416 BIX02189 1094614-85-3 99.86%
BIX02189
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
3,7-DMF
T79603
3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By indu...
DT-6
T79789
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing p...
Nisevokitug
T80562
Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1].
Myristoyl tetrapeptide-12
T80628
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].
(Rac)-SIS3 free base
T12923
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
TGFβ1-IN-1
T61389
TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the s...
Dalbergioidin
TN3753
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
TGFβRI-IN-1
T13137
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
Ponsegromab
T76774
Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor. Ponsegromab has anti-cachexic activity by binding to GDF15 to pre...
Ascrinvacumab
T76858
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has ...
Fresolimumab
T76681
Fresolimumab (GC1008) is a specific human anti-transforming growth factor β monoclonal antibody that binds to the active forms of human TGFβ1, TGFβ2, and TGFβ3 a...
Carotuximab
T76941
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD10...
Garetosmab
T77019
Garetosmab (REGN 2477) is A whole-human IgG4 monoclonal antibody that selectively inhibits activin A and acts on COVID-19 44. Garetosmab has potential anti-cance...
Hydroxysafflor yellow A
T3674
Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver fro...
Pirfenidone
T2386
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, ...
Rubrofusarin gentiobioside
TN2165
Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA bindi...
Alantolactone
T2896
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th...
ITD-1
T2273
ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
SB-431542
T1726
SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other...
BIX02189
T2416
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
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TargetMol