T35348 |
LDN-193189 2HCl
|
1435934-00-1
|
98%
|
|
|
T7377 |
LSKL, Inhibitor of Thrombospondin (TSP-1)
|
283609-79-0
|
98%
|
|
LSKL, Inhibitor of Thrombospondin (TSP-1) is a peptide derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-β.
|
TN3753 |
Dalbergioidin
|
30368-42-4
|
98%
|
|
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
|
T61301 |
Chromenone 1
|
1639929-29-5
|
98%
|
|
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedbac...
|
T13137 |
TGFβRI-IN-1
|
1950628-94-0
|
98%
|
|
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
|
T12923 |
SIS3 free base
|
1009104-85-1
|
98%
|
|
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
|
T9523 |
TGFβRI-IN-3
|
T9523
|
98%
|
|
TGFβRI-IN-3 inhibits TGFβR1 at an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has...
|
T24897 |
TP0427736
|
864374-00-5
|
98%
|
|
TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF...
|
T20319 |
Pentabromophenol
|
608-71-9
|
98%
|
|
Pentabromophenol inhibits TGF-β signaling by accelerating the degradation of type II TGF-β receptors via caveolae-mediated endocytosis.
|
T12433 |
PF-06952229
|
1801333-55-0
|
98%
|
|
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
|
T7676 |
LSKL, Inhibitor of Thrombospondin TSP-1 acetate
|
T7676
|
|
|
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
|
T11052L |
Disitertide acetate
|
|
95.11%
|
|
Disitertide acetate is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitert...
|
T1748 |
Kartogenin
|
4727-31-5
|
96.25%
|
|
Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
|
T3524 |
Halofuginone hydrobromide
|
64924-67-0
|
97.01%
|
|
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
|
T6856 |
Halofuginone
|
55837-20-2
|
97.67%
|
|
Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mamm...
|
T1800 |
GW788388
|
452342-67-5
|
98%
|
|
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
|
T3031 |
A 83-01
|
909910-43-6
|
98%
|
|
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 n...
|
T2109 |
SD-208
|
627536-09-8
|
98%
|
|
SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
|
T8730 |
BMS986260
|
2001559-19-7
|
98.22%
|
|
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
|
T2565 |
Hesperetin
|
520-33-2
|
98.54%
|
|
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges....
|