TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.

Cat. No.	Product name	CAS No.	Purity
T13137	TGFβRI-IN-1	1950628-94-0	98%
T13137	TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
T7377	LSKL, Inhibitor of Thrombospondin (TSP-1)	283609-79-0	98%
T7377	LSKL, Inhibitor of Thrombospondin (TSP-1) is a peptide derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-β.
TN3753	Dalbergioidin	30368-42-4	98%
TN3753	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
T12923	SIS3 free base	1009104-85-1	98%
T12923	SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
T24897	TP0427736	864374-00-5	98%
T24897	TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF...
T20319	Pentabromophenol	608-71-9	98%
T20319	Pentabromophenol inhibits TGF-β signaling by accelerating the degradation of type II TGF-β receptors via caveolae-mediated endocytosis.
T60644	SJ000063181	945189-68-4	98%
T60644	SJ000063181 is a potent BMP signaling activator with an EC 50 ≤1 μM. SJ000063181 can be used as chemical probes to interrogate BMP signaling due to it can penetr...
T7676	LSKL, Inhibitor of Thrombospondin TSP-1 acetate	T7676	98%
T7676	LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
T11052L	Disitertide acetate		98%
T11052L	Disitertide acetate is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitert...
T1748	Kartogenin	4727-31-5	98%
T1748	Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
T6856	Halofuginone	55837-20-2	98%
T6856	Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase（Ki=18.3 nM）, could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mamm...
T9523	TGFβRI-IN-3	2763602-67-9	98%
T9523	TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has poten...
T8730	BMS986260	2001559-19-7	98%
T8730	BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
T3524	Halofuginone hydrobromide	64924-67-0	98%
T3524	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
T2565	Hesperetin	520-33-2	98%
T2565	Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges....
T2109	SD-208	627536-09-8	98%
T2109	SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
T3031	A 83-01	909910-43-6	98%
T3031	A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 n...
T1800	GW788388	452342-67-5	98%
T1800	GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
T6337	RepSox	446859-33-2	98%
T6337	RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.
T3636	(E)-SIS3	521984-48-5	98%
T3636	SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signali...