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PXS 25
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Catalog No. T217751 Copy Product Info
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PXS 25 is a non-cation-dependent inhibitor of the mannose 6-phosphate receptor (CI-M6PR), capable of hindering CI-M6PR-mediated activation of latent TGF-β1. Under normoxic conditions, PXS 25 impedes the high glucose-induced conversion of latent TGF-β1 to its active form in proximal tubular cells. Additionally, it suppresses the production of fibronectin, type IV collagen, and the expression of phosphorylated Smad 2 in these cells. PXS 25 exhibits antifibrotic properties in dermal fibroblasts and is utilized in diabetic nephropathy research.
PXS 25
Cas No. 798546-78-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PXS 25 is a non-cation-dependent inhibitor of the mannose 6-phosphate receptor (CI-M6PR), capable of hindering CI-M6PR-mediated activation of latent TGF-β1. Under normoxic conditions, PXS 25 impedes the high glucose-induced conversion of latent TGF-β1 to its active form in proximal tubular cells. Additionally, it suppresses the production of fibronectin, type IV collagen, and the expression of phosphorylated Smad 2 in these cells. PXS 25 exhibits antifibrotic properties in dermal fibroblasts and is utilized in diabetic nephropathy research. |
| In vitro | PXS 25 (1-200 µM; 72 h) can inhibit high glucose-induced activation of latent TGF-β1, downstream Smad2 signaling, and extracellular matrix production in HK-2 cells under normoxic conditions, without affecting hypoxia-related responses. Additionally, PXS 25 (1-1000 µM; 72 h) exhibits no cytotoxic effects on HK-2 cells under either normoxic or hypoxic conditions, regardless of whether 5 mM or 30 mM D-glucose is used. |
| Molecular Weight | 362.31 |
| Formula | C15H23O8P |
| Cas No. | 798546-78-8 |
| Smiles | O([C@H]1O[C@H](CCP(=O)(O)O)[C@@H](O)[C@H](O)[C@@H]1O)C2=C(C)C=C(C)C=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: PXS 25 in vitro | PXS 25 formula | PXS 25 molecular weight
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