mast

Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

AMG-25 (c-Kit-IN-5-1) is a selective and potent c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used in the study of mast cell-associated fibrosis.

Peptide from giant hornet Vespa orientalis that has biological effects similar to mast cell degranulating peptide from bee venom.

Mast Cell Degranulating Peptide HR-2 acetate from giant hornet Vespa orientalis that has biological effects similar to mast cell degranulating peptide from bee venom.

Mast cell degranulating peptide (28-49) is a bee venom depolarizer that enhances cGMP levels in cerebellum tablets of mice.

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

Marimastat (BB2516) (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM)and MMP-7 (IC50=13 nM).

Ataquimast is used in curing advanced receptor-positive breast cancer.

Bamaquimast (L 0042) is a proton pump inhibitor for the study of asthma-like immune system disorders and respiratory diseases.

Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospasm induced by histamine, methacholine, serotonin, LTC4, or platelet-activating factor. Pirodomast is a potential antiallergic compound. Pirodomast had only weak relaxant activity on guinea pig trachea in vitro. Pirodomast is a potential antiallergic compound that inhibits the protein hydrolyzing activity of trypsin in vitro, prevents antigen-induced immediate and late asthmatic responses in allergic sheep in vivo, and inhibits antigen-induced airway hyperresponsiveness to histamine and carbachol in allergic sheep.

Picumast shows antiallergic activity and can be utilized in the treatment of asthma. Picumast may be used in the treatment of therapeutic allergic airway diseases.

Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.

Stigmasterol (Stigmasterin) is a phytosterol with major functions in the maintenance of cell membrane structure and physiology. Stigmasterol lowers cholesterol levels and has anti-tumor, anti-inflammatory, and immunomodulatory effects.

Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity,In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection.

Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).

Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).

6α-Hydroxystigmast-4-en-3-one is a useful organic compound for research related to life sciences and the catalog number is T124266.

3β,5α-Dihydroxystigmastan-6-one is a useful organic compound for research related to life sciences and the catalog number is T124674.

6-Hydroxystigmasta-4,22-dien-3-one is a useful organic compound for research related to life sciences and the catalog number is T124943.

Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.

Prinomastat (AG3340) is an orally active and selective inhibitor of metalloproteinases (MMPs) that crosses the blood-brain barrier.

Stigmast-7-en-3-ol is a useful organic compound for research related to life sciences and the catalog number is T125511.

Clemastanin A is a useful organic compound for research related to life sciences and the catalog number is T125590.

Masticadienonic acid is a compound derived from Chios mastic gum, with potential anti-inflammatory and anti-cancer activities. It alleviates colitis in mice by modulating inflammatory responses, gut barrier integrity, and the microbiome. Masticadienonic acid is a potential protein tyrosine phosphatase 1B (PTP1B) inhibitor and can be used for research on diabetes.