cr 1

CR-1-31-B, a synthetic rocaglate, acts as a highly potent inhibitor of eIF4A. By disrupting the interaction between eIF4A and RNA, it effectively obstructs the initiation phase of protein synthesis. Specifically, CR-1-31-B interferes with the association between Plasmodium falciparum eIF4A (PfeIF4A) and RNA. Additionally, CR-1-31-B induces apoptosis in neuroblastoma and gallbladder cancer cells [4].

Neboglamine (CR-2249, XY-2401) hydrochloride, an orally active positive modulator of the NMDA receptor glycine site, can be used in schizophrenia research [1].

CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) is a selective inhibitor of MAO-A with IC50 of 202.7 nM and a ligand of I2-imidazoline receptor with IC50 of 596 nM.

Loxiglumide (CR-1505) is an antagonist of cholecystokinin (CCK-1) receptor.

AP 811 acetate is a selective antagonist of the atrial natriuretic peptide clearance receptor (ANP-CR, NPR3), with a high affinity (K_i = 0.48 nM) and over 20,000-fold selectivity for NPR3 compared to NPR1, effectively inhibiting ANP-induced pump stimulation [1] [2].

2,3,5,6-Tetramethoxyaporphine, a benzyl isoquinoline alkaloid with antitussive properties, can be extracted from Glaucium flavum Cr. (Family Papaveraceae) [1] [2].

Lobophorin CR-2, a lobophorin congener, induces UPR-associated gene expression, inhibits oral squamous cell carcinoma cell growth, and causes UPR-dependent cell death in MEF cells [1].