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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T41277 | PACMA 31 | Others | |
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability. | |||
T5586 | CFMS Receptor Inhibitor II | c-Fms | |
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor | |||
T4335 | GNE-617 | GNE617 | NAMPT |
GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer. | |||
T10894 | CSF1R-IN-1 | c-Fms | |
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM. | |||
T14380 | AZD7507 | CSF-1R , HER , Sodium Channel | |
AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity. | |||
T12171 | Nampt-IN-5 | P450 , NAMPT | |
Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) . | |||
T22089 | HPI 1 | Hedgehog/Smoothened | |
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a... | |||
T6682 | STF-118804 | STF 118804,STF118804 | Apoptosis , NAMPT |
STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM. | |||
T6119 | Sotuletinib | BLZ945 | c-Fms , CSF-1R |
Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs. | |||
T13194 | CSF1R-IN-2 | c-Fms , c-Met/HGFR , Src | |
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively). | |||
TQ0015 | PRN1371 | c-Fms , FGFR , CSF-1R | |
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R). | |||
T4376 | Nampt-IN-1 | LSN3154567 | c-Fms , NAMPT , CSF-1R |
Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM. | |||
T10652 | Vimseltinib | DCC-3014 | c-Fms , CSF-1R , c-Kit |
Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM). | |||
T7100 | PLX5622 | PLX-5622 | c-Fms , CSF-1R |
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. | |||
T2115 | Pexidartinib | PLX-3397 | Apoptosis , c-Fms , FLT , CSF-1R , c-Kit |
Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. | |||
T2659 | GW2580 | GW 2580,SC-203877 | c-Fms |
GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS. | |||
T1998 | CHS-828 | CHS 828,GMX1778 | Apoptosis , NAMPT |
CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM). | |||
T12854 | SBI-797812 | NAMPT | |
SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM). | |||
T2624 | OSI-930 | OSI 930 | Apoptosis , c-Fms , Raf , VEGFR , FLT , CSF-1R , Src , c-Kit |
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors. | |||
T15199 | Edicotinib | JNJ-527,JNJ-40346527 | c-Fms , FLT , CSF-1R , c-Kit |
Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote... |