cation

Calmidazolium (cation) is a powerful inhibitor of or red blood cell Ca -ATPase & Ca transport into inside-out red blood cell vesicles; an antagonist of calmodulin.

Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic piperazine derivative with hypotensive antiadrenergic properties, It is used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.

Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes, uncouples oxidative phosphorylation, and inhibits ATPase of rat liver mitochondria. The substance is primarily used as a biochemical tool to study the role of divalent cations in various biological systems.

AS1269574 (AS 1269574) is a potent, orally available GPR119 agonist with potential for type 2 diabetes research.

TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.

CW-002 cation is an investigational fumarate-based non-depolarizing muscle relaxant.

CHF-6333 CATION is a compound that inhibits human neutrophil elastase.

LX-201 cation is a bioactive chemical.

Tetrabutylphosphonium cation is a light orange solid and is the salt of the liphilic tetrabutylammonium cation and linear tribromide anion.

CEX Cation-exchange resin 1 is a cation-exchange chromatography medium, based on monodisperse polystyrene/divinylbenzene (PS-DVB). With a particle size of 50 μm, its functional group is -CH2CH2CH2SO3-. CEX Cation-exchange resin 1 is suitable for the separation and purification of antibodies, VLPs, viruses, and proteins.

CEX Cation-exchange resin 2 is a strong cation-exchange resin and an ADC purification resin. It contains cross-linked poly(styrene-divinylbenzene) and exhibits excellent hydrophobicity.

IAV replication-IN-1 (compound 3h) can reduce the upregulation of inflammatory factors and apoptosis caused by IAV infection and alleviate lung damage resulting from IAV infection.

Glycation-IN-1 (Compound 3) is an inhibitor of the glycosylation reaction, effectively suppressing the synthesis of the initial, intermediate, and final products of glycation reactions. It is applicable in research on various chronic diseases, including diabetes, immune inflammation, cardiovascular diseases, and neurodegenerative disorders.

Cemdisiran, an investigational N-acetylgalactosamine-conjugated RNAi (RNA interference) agent with terminal sugar modification, is a small interfering RNA (siRNA) designed to specifically target and suppress the C5 mRNA, thereby reducing the liver's production of the complement component C5 [1].

Cationic Bovine Serum Albumin is a protein composed of 583 amino acids and contains three homologous all-α domains. When used in combination with Tanshinone IIA (HY-N0135), it exhibits significant neuroprotective effects in ischemic stroke. It is also commonly used to induce membranous nephropathy (MN) models.

PKC-ε Translocation Inhibitor Peptide is a selective modulator that controls the FcγR-mediated internalization rate of opsonized beads without affecting FcαR trafficking [1].

AC Antibody Purification Resin 2 is composed of spherical, highly cross-linked agarose beads characterized by a narrow size distribution and strong mechanical stability. It is utilized for the separation and purification of complex antibodies such as monoclonal, bispecific, and polyclonal antibodies as well as Fc fusion proteins. [Substrate: Highly cross-linked agarose microspheres; Particle size: 65μm; Ligand: Alkali-resistant recombinant Protein A; ADC Purification Resin.]

AC Antibody Purification Resin 1 is a 69μm nanometer-sized agarose designed for ADC purification. It contains the ligand: recombinant protein A.

AC mAb-X purification resin is a specialized Protein A resin. It features a highly rigid agarose matrix and particle sizes ranging from 40 to 120 μm. The ligand is a recombinant alkaline-resistant Protein A (~24KD), and it serves as a purification resin for ADC.

Cationomycin is effective against Gram-positive bacteria and mycobacteria, but it shows no activity against Gram-negative bacteria, yeast, or fungi. When added to feed at a concentration of 50 to 100 ppm, Cationomycin can effectively suppress coccidiosis in chickens.

Advanced glycation end products are the outcome of non-enzymatic glycation reactions involving biomolecules such as proteins, lipids, nucleic acids, and reducing sugars. Advanced glycation end products are frequently employed in investigating pathological mechanisms associated with diabetes, ageing, and chronic diseases.

Potassium chloride is an inorganic salt that meets the analytical specifications of Ph. Eur., BP, USP, FCC, and E508, with an aluminum content of ≤0.0001%. It is suitable for use in buffer solution preparation.

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid extracted from the seeds of Crotalaria plants. It inhibits organic cation transporters OCT-1 and OCT-2, with IC50 values of 36.8 µM and 1.8 mM, respectively. Monocrotaline exhibits antitumor activity and shows certain cytotoxicity against liver cancer cells such as HepG2. It is also commonly used to induce pulmonary arterial hypertension models in rodents.

D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.