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Search Result

Search Results for "epigenetic reader domain"

Targets

Epigenetic Reader Domain

Compounds

Cat No. Product Name
T15424 GSK1379725A Epigenetic Reader Domain
GSK1379725A 是一种选择性 BPTF 配体，Kd 为 2.8 μM。
T2072 BET bromodomain inhibitor Epigenetic Reader Domain
BET bromodomain inhibitor 是 BET 的一种有效抑制剂，来自专利 WO/2015/153871A2，化合物实例11。
T11925 M‑89 Histone Methyltransferase , Epigenetic Reader Domain
M-89 可抑制 Menin-MLL 蛋白之间的相互作用，有研究混合谱系白血病的潜力。它是一种强特异性 menin 抑制剂，结合到 menin 的Kd 值为 1.4 nM。
T11136 E-7386 E7386 Epigenetic Reader Domain
E-7386 是是一种有口服活性的 CBP/-catenin 调节剂。
T5362 Y06036 Epigenetic Reader Domain
Y06036 是一种选择性 BET 抑制剂，具有抗肿瘤活性，可与 BRD4(1)溴结构域结合，Kd 值为 82 nM。
T16072 MI-538 Histone Methyltransferase , Epigenetic Reader Domain
MI-538是一种menin 和MLL 融合蛋白相互作用的抑制剂，IC50值为 21 nM。
TQ0058 MI-463 Histone Methyltransferase , Epigenetic Reader Domain
MI-463 是一种有口服活性的menin-mLL 相互作用的高效小分子抑制剂，IC50为15.3 nM。
T3311 GSK6853 Epigenetic Reader Domain
GSK6853 是一种强选择性RPF1乙酰赖氨酸抑制剂，pKd 为9.5，其选择性是其它的乙酰赖氨酸的 1600 倍。
T1854 MS436 Epigenetic Reader Domain
MS436 是溴结构域抑制剂，作用于 BRD4 BrD1的Ki 为 30 到 50 nM 之间，比作用于 BrD2 选择性高 10 倍。
TQ0069 MI-503 Histone Methyltransferase , Epigenetic Reader Domain
MI-503 是一种高效且可口服的 menin-mLL 相互作用抑制剂。
T2127 OF-1 Epigenetic Reader Domain
OF-1 是溴结构域的一种抑制剂，其对TRIM24 和BRPF1B 的IC50值分别为270 mM 和1.2 μM。
TQ0083 NI-57 Epigenetic Reader Domain
NI-57 是溴结构域和植物同源锌指结构域 (BRPF) 蛋白家族的一种抑制剂，对 BRPF1、BRPF2 (BRD1) 和 BRPF3 的 IC50值分别为 3.1、46 和 140 nM。
T12112 MS402 Epigenetic Reader Domain
MS402 是一种新型 BD1 选择性 BET BrD 抑制剂，阻断 Th17 细胞分化并改善小鼠结肠炎，对BRD4(BD1)、BRD4(BD2)、BRD3(BD1)、BRD3(BD2)、BRD2(BD1)和BRD2(BD2)的Ki 分别为...
T16321 NI-42 Epigenetic Reader Domain
NI-42 是一种用于 BRPF 的结构正交化学探针，是有偏向性的BRPFs 溴结构域 (BRD)抑制剂，BRPF1、2和3的IC50为7.9、48和260 nM; BRPF1、2和3的Kd 值为40、210和940 nM，与非分类 IV ...
T6783 BI-7273 Epigenetic Reader Domain
BI7273 是一种选择性的可细胞透过BRD9抑制剂，IC50和Kd 分别为 19 和 0.75 nM。它对 BRD7 的作用较强，IC50和Kd 值分别为 117 和 0.3 nM。
TQ0253 PLX51107 Epigenetic Reader Domain
PLX51107 是一种选择性 BET 抑制剂，与 CBP 和 EP300 的结构域相互作用。它对 BRD2、BRD3、BRD4 和 BRDT 的 BD1 结构域的亲和力Kd 值分别为 1.6、2.1、1.7 和 5 nM，BD2 结构域亲...
T6939 PFI-3 PFI 3 Epigenetic Reader Domain
PFI3是一种选择性，可渗透细胞的SMARCA2/4溴结构域抑制剂，Kd 值为89 nM，可延迟和预防乳腺癌。
T9749 FHD-286 Epigenetic Reader Domain
FHD-286 是 BRM/BRG1 ATPase 的抑制剂，可用于治疗 BAF 相关疾病如急性髓性白血病的研究。
T19935 XD14 Epigenetic Reader Domain
XD14 是BET 抑制剂，其与 BRD2、BRD3 和 BRD4 的结合常数分别为 170 nM、380 nM 和 160 nM。它具有抗肿瘤活性。
T13363 Y06137 PKC , Epigenetic Reader Domain
Y06137 是一种有效的特异性 BET 抑制剂，对 BRD4(1) 溴结构域的 Kd 为 81 nM。 Y06137可用于去势抵抗性前列腺癌治疗的研究。
GSK1379725A
T15424
synonym:
Target:
BET bromodomain inhibitor
T2072
synonym:
Target:
M‑89
T11925
synonym:
Target:
E-7386
T11136
synonym: E7386
Target:
Y06036
T5362
synonym:
Target:
MI-538
T16072
synonym:
Target:
MI-463
TQ0058
synonym:
Target:
GSK6853
T3311
synonym:
Target:
MS436
T1854
synonym:
Target:
MI-503
TQ0069
synonym:
Target:
OF-1
T2127
synonym:
Target:
NI-57
TQ0083
synonym:
Target:
MS402
T12112
synonym:
Target:
NI-42
T16321
synonym:
Target:
BI-7273
T6783
synonym:
Target:
PLX51107
TQ0253
synonym:
Target:
PFI-3
T6939
synonym: PFI 3
Target:
FHD-286
T9749
synonym:
Target:
XD14
T19935
synonym:
Target:
Y06137
T13363
synonym:
Target:
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