| T1056 |
Isoprenaline hydrochlorideHOT |
Isoproterenol is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
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| T1713 |
IBMXHOT |
IBMX is a pan-phosphodiesterase (PDE) inhibitor (IC50s: 6.5/26.3/31.7 μM for PDE3/PDE4/PDE5).
|
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| T6054 |
GSK256066 |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selec...
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| T4097 |
Vardenafil hydrochloride trihydrate |
Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
|
|
| T4041 |
GLPG1690 |
GLPG-1690, an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
|
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| T6649 |
S- (+)-Rolipram |
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous ...
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| T0625 |
Theobromine |
3, 7-Dimethylxanthine, a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
|
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| T3465 |
Vesnarinone |
Vesnarinone (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal neg...
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| T50062 |
2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide |
2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.
|
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| T3987 |
Lotamilast |
E6005 is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
|
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| T1096 |
Milrinone |
Milrinone is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.
|
|
| T1708 |
Pimobendan |
Pimobendan is a selective inhibitor of PDE3 (IC50: 0.32 μM).
|
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| T0462 |
Cilostazol |
Cilostazol is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
|
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| T0480 |
Doxofylline |
Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown...
|
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| T0160 |
Anagrelide |
Anagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagrelide is by ...
|
|
| T2205 |
Theophylline-7-acetic acid |
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
|
|
| T0070 |
Pentoxifylline |
Pentoxifylline modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase a...
|
|
| T4285 |
Crisaborole |
AN-2728 is a Phosphodiesterase 4 Inhibitor.
|
|
| T4462 |
Roflumilast N-oxide |
Roflumilast N-oxide is a PDE type 4 inhibitor.
|
|
| T6644 |
Rolipram |
Rolipram is a phosphodiesterase 4 inhibitor with antidepressant properties.
|
|
| T5474 |
D 159687 |
D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxio...
|
|
| T7642 |
Cilostamide |
Cilostamide is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)
|
|
| T7542 |
Amino Tadalafil |
Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.
|
|
| T7346 |
Lodenafil |
Lodenafil is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)
|
|
| T5940 |
Proxyphylline |
Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and ...
|
|
| T6147 |
Nortadalafil |
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary art...
|
|
| T5956 |
VP3.15 dihydrobromide |
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1....
|
|
| T5411 |
SEP-0372814 |
PDE10-IN-1 is PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders.
|
|
| T4480 |
Vardenafil dihydrochloride |
Vardenafil dihydrochloride is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
|
|
| T6S2115 |
Ginkgolide J |
Ginkgolide J has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices...
|
|
| T5101 |
BW-A78U |
BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.
|
|
| T5033 |
Olprinone |
Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olpr...
|
|
| T5106 |
BRL 50481 |
BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.
|
|
| T4S0792 |
(+)-pinoresinol-β-D-glucoside; (+)-pinor |
|
|
| T4695 |
CP671305 |
CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.
|
|
| T0264 |
Zomepirac Sodium |
Zomepirac sodium salt is a prostaglandin synthetase inhibitor.
|
|
| T1265 |
Amrinone |
Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
|
|
| T2923 |
Apremilast |
Apremilast (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
|
|
| T6445 |
Cilomilast |
Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.
|
|
| T1681 |
Aminophylline |
Aminophylline is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
|
|
| T0096 |
Vardenafil |
Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
|
|
| T0467 |
Sildenafil citrate |
Sildenafil, a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erectile dysfunction and less com...
|
|
| T1398 |
Tadalafil |
Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phos...
|
|
| T1024 |
Roflumilast |
Roflumilast is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activitie...
|
|
| T0080 |
Trapidil |
Trapidil is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic ...
|
|
| T3224 |
DprE1-IN-1 |
DprE1-IN-1 is a potent inhibitor of DprE1 and PDE6.
|
|
| T2334 |
Avanafil |
Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
|
|
| T6462 |
Deltarasin |
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
|
|
| T1164 |
Sildenafil |
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction and reduce symptoms of pulmonary arterial hypertension (PAH).
|
|
| T6983 |
Sildenafil Mesylate |
Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
|
|
| T6042 |
[11C]MP 10 |
[11C]MP 10, a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.
|
|
| T1745 |
TAK063 |
TAK-063 is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.
|
|
| T2646 |
HA130 |
HA130 is a selective ATX (autotaxin) inhibitor.
|
|
| T0705 |
Triflusal |
Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
|
|
| T0994 |
Ketotifen fumarate |
Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
|
|
| T7954 |
YM976 |
YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)
|
|
| T0045 |
Heptaminol hydrochloride |
Heptaminol hydrochloride, a vasoconstrictor, is used in the therapy of hypotension, especially orthostatic hypotension.
|
|
| T1083L |
Theophylline monohydrate |
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
|
|
| T1112 |
2-(Hydroxymethyl)pyridine |
2-Pyridinylmethanol is an organic compound.
|
|
| T6390 |
Anagrelide HCl |
Anagrelide Hydrochloride(BL4162A) is a drug used for the treatment of essential thrombocytosis.
|
|
| T1083 |
Theophylline |
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
|
|
| T1618 |
Dypyridamole |
Dipyridamole is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
|
|
| T6548 |
Irsogladine |
Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
|
|
| T0458 |
Indometacin |
Indomethacin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
|
|
| T2129 |
Zaprinast |
Zaprinast was an unsuccessful Clinicalal drug candidate that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which succes...
|
|
| T2137 |
Ibudilast |
Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.
|
|
| T0383 |
Fenspiride hydrochloride |
Fenspiride, an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of c...
|
|
| T1027 |
Luteolin |
Luteolin is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentr...
|
|
| T2855 |
Icariin |
Icariin is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
|
|
| T0892 |
Diprophylline |
Dyphylline is a xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline proba...
|
|
| T0167 |
Vinpocetine |
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
|
|
| TQ0126 |
Mirodenafil dihydrochloride |
Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
|
|
| T8405 |
Vardenafil hydrochloride |
Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes
|
|
| T9239 |
RS-25344 |
RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vi...
|
|
| T16478 |
PF-04447943 |
PF-04447943 is an effective inhibitor of human recombinant PDE9A (IC50=12 nM). It has >78-fold selectivity, compared to other PDE family members (IC50>1000 nM).
|
|
| T17199 |
Udenafil |
Udenafil is an inhibitor of PDE5 .
|
|
| T16976 |
TAK-915 |
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
|
|
| T16499 |
Mardepodect |
Mardepodect is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful ...
|
|
| T16498 |
Mardepodect hydrochloride (898562-94-2 free base) |
Mardepodect hydrochloride can cross the blood-brain barrier. Mardepodect hydrochloride is an effective and selective PDE10A inhibitor (IC50: 0.37 nM). It has >10...
|
|
| T16484 |
PF-05180999 |
PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
|
|
| T16482 |
PF-05085727 |
PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11. PF-05085727 is an effective, selective and brain penetrant inhibitor of cGMP-dependent ...
|
|
| T16434 |
PAT-048 |
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no ef...
|
|
| TN4317 |
Isopedicin |
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
|
|
| T5496 |
ML-030 |
ML-030 is a potent and selective inhibitor of PDE4(PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2 with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49...
|
|
| T16272 |
Naproxen etemesil |
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of napro...
|
|
| T16164 |
MY-5445 |
MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
|
|
| T16079 |
Mirodenafil |
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
|
|
| T11689 |
ITI214 |
ITI214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion...
|
|
| T15766 |
Lirimilast |
Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties...
|
|
| TN2974 |
3-O-Methylquercetin tetraacetate |
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiv...
|
|
| TN4397 |
Kuraridine |
Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
|
|
| T10841 |
CM-675 |
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to tre...
|
|
| T19865 |
GEBR-7b |
GEBR-7b is a phosphodiesterase-4 (PDE4) inhibitor.
|
|
| T31101 |
CRT0273750 |
CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.
|
|
| T25376 |
Ensifentrine |
Ensifentrine is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical ...
|
|
| T24656 |
PQ-10 |
PQ-10 is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.
|
|
| T8919 |
Homo Sildenafil |
Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.
|
|
| T22086 |
HA-155 |
HA155 is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.
|
|
| T21965 |
MBCQ |
MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.
|
|
| T19706 |
Ro20-1724 |
Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.
|
|
| TN4665 |
Norbraylin |
Norbraylin is a natural product from Toddalia asiatica.
|
|
| T8506 |
THPP-1 |
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
|
|
| T8787 |
Drotaverine hydrochloride |
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation duri...
|
|
| T8659 |
K-Ras-PDEδ-IN-1 |
K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
|
|
| T23256 |
RS 25344 hydrochloride |
RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor
|
|
| T23256 |
RS 25344 hydrochloride |
RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor
|
|
| T23154 |
Piclamilast |
Piclamilast is a PDE4 inhibitor.
|
|
| T22851 |
ICI 63197 |
ICI 63197 is a PDE4 inhibitor.
|
|
| T15640 |
K134 |
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
|
|
| T13232 |
TyK2-IN-2 |
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
|
|
| TN1266 |
3-O-Methylquercetin |
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
|
|
| T12150 |
N-Methylbenzamide |
N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.
|
|
| T10994L2 |
Deltasonamide 2 (TFA) |
Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
|
|
| T10994L |
Deltasonamide 2 hydrochloride |
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.
|
|
| T12394 |
PDE5-IN-2 |
PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
|
|
| T12372 |
PAT-505 |
PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma)....
|
|
| T12315 |
OR-1896 |
OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator.
|
|
| T12267 |
NSP-805 |
NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.
|
|
| T12103 |
MR-L2 |
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
|
|
| T8462 |
Enoximone |
Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.
|
|
| T8454 |
SEP-0372814 |
SEP-0372814 is a potent inhibitor of PDE10.
|
|
| T8515 |
BI-409306 |
BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory
|
|
| TN2159 |
Robustine |
Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro.
|
|
| TN2095 |
Pomiferin |
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
|
|
| TN1950 |
Moracin M |
Moracin M is a phytoalexin. Moracin M inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, >40, and >100 μM, respectively.
|
|
| TN1843 |
Kushenol K |
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
|
|
| T10994 |
Deltasonamide 2 |
Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
|
|
| T14352 |
Autotaxin-IN-1 |
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...
|
|
| T13193 |
TPN171 |
TPN171 is a selective and oral bioavailable phosphodiesterase type 5 (PDE5) inhibitor (IC50: 0.62 nM), which has the potential for the treatment of pulmonary art...
|
|
| T14962 |
CI-1044 |
CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
|
|
| T11533 |
HA155 |
HA155 selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.
|
|
| T11483 |
GSK 256066 Trifluoroacetate |
GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of ch...
|
|
| T10730 |
CDC801 |
CDC801 is a potent and orally active inhibitor of PDE4 and TNF-α (IC50: 1.1 μM and 2.5 μM).
|
|
| T10676 |
Carbodenafil |
Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).
|
|
| T11206 |
Ent-Tadalafil |
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).
|
|
| T15381 |
Gisadenafil |
Gisadenafil is a specific and orally active inhibitor of PDE5 (IC50: 3.6 nM). It also prevents the degradation of cyclic guanosine monophosphate (cGMP).
|
|
| T10417 |
Autotaxin-IN-5 |
Autotaxin-IN-5 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 63). It has the potential to treat idiopathic pulmonary fibrosis.
|
|
| T14507 |
Bay 60-7550 |
Bay 60-7550 is an inhibitor of PDE2(Ki: 3.8 nM).
|
|
| T10416 |
Autotaxin-IN-4 |
Autotaxin-IN-4 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 51). It has the potential to treat idiopathic pulmonary fibrosis.
|
|
| T10415 |
Autotaxin-IN-3 |
Autotaxin-IN-3 is an Autotaxin(ATX) inhibitor (IC50: 2.4 nM) sourced from patent WO2018212534A1 (compound 33).
|
|
| T10418 |
Autotaxin modulator 1 |
Autotaxin modulator 1 is a new modulator of Autotaxin extracted from Patent WO 2014018881 A1.
|
|
| T10409 |
ATX inhibitor 5 |
ATX inhibitor 5 is an orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM). It has an anti-hepatofibrosis effect and reduces CCl4-induced hepatic fibrosis lev...
|
|
| T10410 |
ATX inhibitor 1 |
ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).
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| T10350 |
Apremilast D5 |
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α rel...
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| T10481L |
BAY 73-6691 |
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
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| T3631 |
PF8380 |
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysopho...
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