TN2095 |
Pomiferin
|
572-03-2
|
98%
|
|
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
|
T10316 |
AN3199
|
1187187-10-5
|
98%
|
|
AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
|
T14962 |
CI-1044
|
197894-84-1
|
98%
|
|
CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
|
TN1843 |
Kushenol K
|
101236-49-1
|
98%
|
|
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
|
T10416 |
Autotaxin-IN-4
|
2156655-86-4
|
98%
|
|
Autotaxin-IN-4 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 51). It has the potential to treat idiopathic pulmonary fibrosis.
|
T0096 |
Vardenafil
|
224785-90-4
|
98%
|
|
Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
|
T13232 |
TyK2-IN-2
|
2098466-94-3
|
98%
|
|
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
|
T12372 |
PAT-505
|
1782070-22-7
|
98%
|
|
PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma)....
|
T63190 |
Cudetaxestat
|
1782070-21-6
|
98%
|
|
Cudetaxestat (BLD-0409) is a potent and orally active inhibitor of autotaxin (ATX).
|
T16434 |
PAT-048
|
1359983-15-5
|
98%
|
|
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no ef...
|
T15766 |
Lirimilast
|
329306-27-6
|
98%
|
|
Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties...
|
T15640 |
K134
|
189362-06-9
|
98%
|
|
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
|
T14352 |
Autotaxin-IN-1
|
1619971-30-0
|
98%
|
|
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...
|
T16976 |
TAK-915
|
1476727-50-0
|
98%
|
|
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
|
T12394 |
PDE5-IN-2
|
2244517-61-9
|
98%
|
|
PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
|
TN4317 |
Isopedicin
|
4431-42-9
|
98%
|
|
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
|
T10481L |
BAY 73-6691
|
794568-92-6
|
98%
|
|
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
|
TN4665 |
Norbraylin
|
60796-64-7
|
98%
|
|
Norbraylin is a natural product from Toddalia asiatica.
|
T16484 |
PF-05180999
|
1394033-54-5
|
98%
|
|
PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
|
TN4397 |
Kuraridine
|
34981-25-4
|
98%
|
|
Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
|