PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
TN2095	Pomiferin	572-03-2	98%
TN2095	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
T10316	AN3199	1187187-10-5	98%
T10316	AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
T14962	CI-1044	197894-84-1	98%
T14962	CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
TN1843	Kushenol K	101236-49-1	98%
TN1843	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
T10416	Autotaxin-IN-4	2156655-86-4	98%
T10416	Autotaxin-IN-4 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 51). It has the potential to treat idiopathic pulmonary fibrosis.
T0096	Vardenafil	224785-90-4	98%
T0096	Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
T13232	TyK2-IN-2	2098466-94-3	98%
T13232	TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
T12372	PAT-505	1782070-22-7	98%
T12372	PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma)....
T63190	Cudetaxestat	1782070-21-6	98%
T63190	Cudetaxestat (BLD-0409) is a potent and orally active inhibitor of autotaxin (ATX).
T16434	PAT-048	1359983-15-5	98%
T16434	PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no ef...
T15766	Lirimilast	329306-27-6	98%
T15766	Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties...
T15640	K134	189362-06-9	98%
T15640	K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
T14352	Autotaxin-IN-1	1619971-30-0	98%
T14352	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...
T16976	TAK-915	1476727-50-0	98%
T16976	TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
T12394	PDE5-IN-2	2244517-61-9	98%
T12394	PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
TN4317	Isopedicin	4431-42-9	98%
TN4317	Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
T10481L	BAY 73-6691	794568-92-6	98%
T10481L	BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
TN4665	Norbraylin	60796-64-7	98%
TN4665	Norbraylin is a natural product from Toddalia asiatica.
T16484	PF-05180999	1394033-54-5	98%
T16484	PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
TN4397	Kuraridine	34981-25-4	98%
TN4397	Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.