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PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2095 Pomiferin 572-03-2 98%
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
T10316 AN3199 1187187-10-5 98%
AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
T14962 CI-1044 197894-84-1 98%
CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
TN1843 Kushenol K 101236-49-1 98%
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
T10416 Autotaxin-IN-4 2156655-86-4 98%
Autotaxin-IN-4 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 51). It has the potential to treat idiopathic pulmonary fibrosis.
T0096 Vardenafil 224785-90-4 98%
Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
T13232 TyK2-IN-2 2098466-94-3 98%
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
T12372 PAT-505 1782070-22-7 98%
PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma)....
T63190 Cudetaxestat 1782070-21-6 98%
Cudetaxestat (BLD-0409) is a potent and orally active inhibitor of autotaxin (ATX).
T16434 PAT-048 1359983-15-5 98%
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no ef...
T15766 Lirimilast 329306-27-6 98%
Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties...
T15640 K134 189362-06-9 98%
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
T14352 Autotaxin-IN-1 1619971-30-0 98%
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...
T16976 TAK-915 1476727-50-0 98%
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
T12394 PDE5-IN-2 2244517-61-9 98%
PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
TN4317 Isopedicin 4431-42-9 98%
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
T10481L BAY 73-6691 794568-92-6 98%
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
TN4665 Norbraylin 60796-64-7 98%
Norbraylin is a natural product from Toddalia asiatica.
T16484 PF-05180999 1394033-54-5 98%
PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
TN4397 Kuraridine 34981-25-4 98%
Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
Pomiferin
TN2095
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
AN3199
T10316
AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
CI-1044
T14962
CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).
Kushenol K
TN1843
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
Autotaxin-IN-4
T10416
Autotaxin-IN-4 is an Autotaxin inhibitor extracted from patent WO2018212534A1 (compound 51). It has the potential to treat idiopathic pulmonary fibrosis.
Vardenafil
T0096
Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific ...
TyK2-IN-2
T13232
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
PAT-505
T12372
PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma)....
Cudetaxestat
T63190
Cudetaxestat (BLD-0409) is a potent and orally active inhibitor of autotaxin (ATX).
PAT-048
T16434
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no ef...
Lirimilast
T15766
Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties...
K134
T15640
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.
Autotaxin-IN-1
T14352
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...
TAK-915
T16976
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
PDE5-IN-2
T12394
PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)
Isopedicin
TN4317
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
BAY 73-6691
T10481L
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
Norbraylin
TN4665
Norbraylin is a natural product from Toddalia asiatica.
PF-05180999
T16484
PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM).
Kuraridine
TN4397
Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents.
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