Search Result

Search Results for " cyclooxygenase "

Targets

202

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T7670	Mavacoxib		COX
	Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.		COX
T9472	Rebamipide mofetil		COX
	Rebamipide mofetil is an orally active prodrug of Rebamipide which is a mucoprotective agent.		COX
T6497	Fenoprofen Calcium		Others , COX
	Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.		Others , COX
T2553	Etofenamate		COX
	Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.		COX
T11005	Desmethyl Celecoxib		COX
	Demethyl celecoxib is a selective inhibitor of COX-2 with anti-inflammatory activity (IC50 of 32 nM). with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.		COX
T1582	Naproxen	(S)-Naproxen	COX , Autophagy
	Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.		COX , Autophagy
T15577	Indobufen	Ibustrin	COX
	Indobufen (Ibustrin) is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue fac...		COX
T4101	SC-560	SC560	COX
	SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.		COX
T2550	Tolmetin	Tolectin	COX
	Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds.		COX
T3954	Adelmidrol		NF-κB , COX , PPAR
	Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.		NF-κB , COX , PPAR
T0285	Isoxicam	Isoxicamum,Isoxicamo,Maxicam	COX
	Isoxicam (Isoxicamum) is a non-steroidal anti-inflammatory drug that is not marketed in the United States.		COX
T0778	Phenacetin	Acetophenetidin	COX
	Phenacetin (Acetophenetidin) is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.		COX
T12580	PTUPB		COX , Epoxide Hydrolase
	PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).		COX , Epoxide Hydrolase
T0826	Meloxicam	Movalis,Mobic,Metacam	Apoptosis , COX , Autophagy
	Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxicam is Nonsteroidal Anti-inflammatory Compounds.		Apoptosis , COX , Autophagy
T1133	Nimesulide	R805	COX
	Nimesulide (R805) is a relatively COX-2 selective inhibitor with analgesic and antipyretic properties.		COX
T15645	Pamicogrel	KBT3022	COX
	Pamicogrel (KBT3022) is an inhibitor of COX.		COX
T0705	Triflusal	UR1501	COX , PDE , PPAR
	Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.		COX , PDE , PPAR
T1432	Phenylbutazone	Butazolidine	COX
	Phenylbutazone (Butazolidine) is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylitis, rheumatoid arthritis, and reactive arthri...		COX
T22437	Tazofelone	LY-213829	Others
	Tazofelone (LY-213829) is a NSAID used for the treatment of inflammatory bowel disease.		Others
T15571	Imrecoxib	BAP-909	COX
	Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-inflammatory effect.		COX
T3500	Flurbiprofen Axetil	Ropion,Lipfen,Ropiopn	COX
	Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.		COX
T0758	Piroxicam	CP-16171	COX
	Piroxicam (CP-16171) is a non-specific COX inhibitor.		COX
T5032	Iguratimod	T614	Others , COX
	Iguratimod (T614) is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an I...		Others , COX
T1258	Nabumetone	BRL14777	COX , Glutathione Peroxidase
	Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.		COX , Glutathione Peroxidase
T1325	Carprofen	Ridamyl,Imadyl,Rimadyl	FAAH , COX , Autophagy
	Carprofen (Ridamyl) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities.		FAAH , COX , Autophagy
T6387	Ampiroxicam	CP 65703,Flucam	COX
	Ampiroxicam (Flucam) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.		COX
T5460	Mofezolac		COX
	Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000		COX
T5843L	(S)-Flurbiprofen	esflurbiprofen	COX , PGE Synthase
	Esflurbiprofen is an inhibitor of COX-1 and COX-2.		COX , PGE Synthase
T0432	Diclofenac diethylamine		Apoptosis , COX
	Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).		Apoptosis , COX
T2405	Revaprazan hydrochloride	YH1885	ATPase , COX , Antibacterial
	Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.		ATPase , COX , Antibacterial
T1421	Aceclofenac	Preservex,Airtal	COX
	Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.		COX
T0466	Celecoxib	SC 58635	COX
	Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.		COX
T2367	SKF-86002	SKF86002	p38 MAPK , TNF
	SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).		p38 MAPK , TNF
T6568	Licofelone	ML-3000	Apoptosis , Lipoxygenase , COX
	Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity ass...		Apoptosis , Lipoxygenase , COX
T0219	Valdecoxib	SC 65872	COX
	Valdecoxib (SC 65872) is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or N...		COX
T10152	4-Methylamino antipyrine		COX , Drug Metabolite
	4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relativel...		COX , Drug Metabolite
T1867	Otenaproxesul	ATB 346	Apoptosis , COX
	Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.		Apoptosis , COX
T7882	Indomethacin farnesil	Infree	Others , COX , Autophagy
	Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (DMARD).		Others , COX , Autophagy
T8356	FPL 62064		Lipoxygenase , COX
	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).		Lipoxygenase , COX
T0291	Flurbiprofen	dl-Flurbiprofen	Apoptosis , COX , MRP
	Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.		Apoptosis , COX , MRP
T0159	Pranoprofen	Pyranoprofen	Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
	Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.		Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
T0463	Loxoprofen	Loxoprofene,Loxoprofeno,Koloxo	COX
	Loxoprofen (Koloxo) is an anti-inflammatory non-steroidal medicine.		COX
T7540	2,5-Di-tert-butylhydroquinone	BHQ	Calcium Channel , Lipoxygenase , COX
	2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.		Calcium Channel , Lipoxygenase , COX
T1191L	Metamizole sodium	Analgin,Dipyron	COX
	Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.		COX
T22368	Metyrosine	α-Methyltyrosine	COX
	Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressu...		COX
T0784	Tolfenamic Acid	GEA 6414,Tolfedine	COX
	Tolfenamic Acid (GEA 6414) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.		COX
T1586	Tenoxicam	Ro-12-0068,Tenoxicamum,Mobiflex,Tilcotil	COX
	Tenoxicam (Tilcotil), an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.		COX
T7838	Losartan Carboxaldehyde		COX
	Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.		COX
T7596	Firocoxib	ML 1785713	COX
	Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.		COX
T6424	Bromfenac Sodium	AHR 10282B,Bronuck,AHR 10282R	COX
	Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.		COX

Compounds

Synonym: (S)-Naproxen

Target: COX, Autophagy

Target: NF-κB, COX, PPAR

Isoxicam

T0285

Synonym: Isoxicamum,Isoxicamo,Maxicam

Target: COX

Phenacetin

T0778

Synonym: Acetophenetidin

Target: COX, Epoxide Hydrolase

Meloxicam

T0826

Synonym: Movalis,Mobic,Metacam

Target: Apoptosis, COX, Autophagy

Target: COX, PDE, PPAR

Phenylbutazone

T1432

Synonym: Butazolidine

Synonym: Ropion,Lipfen,Ropiopn

Target: COX, Glutathione Peroxidase

Carprofen

T1325

Synonym: Ridamyl,Imadyl,Rimadyl

Target: FAAH, COX, Autophagy

Ampiroxicam

T6387

Synonym: CP 65703,Flucam

Synonym: esflurbiprofen

Target: COX, PGE Synthase

Diclofenac diethylamine

T0432

Synonym:

Target: Apoptosis, COX

Revaprazan hydrochloride

T2405

Synonym: YH1885

Target: ATPase, COX, Antibacterial

Aceclofenac

T1421

Synonym: Preservex,Airtal

Target: p38 MAPK, TNF

Licofelone

T6568

Synonym: ML-3000

Target: Apoptosis, Lipoxygenase, COX

4-Methylamino antipyrine

T10152

Synonym:

Target: COX, Drug Metabolite

Otenaproxesul

T1867

Synonym: ATB 346

Target: Apoptosis, COX

Indomethacin farnesil

T7882

Synonym: Infree

Target: Others, COX, Autophagy

FPL 62064

T8356

Synonym:

Target: Lipoxygenase, COX

Flurbiprofen

T0291

Synonym: dl-Flurbiprofen

Target: Apoptosis, COX, MRP

Pranoprofen

T0159

Synonym: Pyranoprofen

Target: Apoptosis, COX, PGE Synthase, Prostaglandin Receptor

Loxoprofen

T0463

Synonym: Loxoprofene,Loxoprofeno,Koloxo

Target: COX

2,5-Di-tert-butylhydroquinone

T7540

Synonym: BHQ

Target: Calcium Channel, Lipoxygenase, COX

Metamizole sodium

T1191L

Synonym: Analgin,Dipyron

Target: COX

Metyrosine

T22368

Synonym: α-Methyltyrosine

Target: COX

Tolfenamic Acid

T0784

Synonym: GEA 6414,Tolfedine

Target: COX

Tenoxicam

T1586

Synonym: Ro-12-0068,Tenoxicamum,Mobiflex,Tilcotil

Target: COX

Losartan Carboxaldehyde

Synonym: AHR 10282B,Bronuck,AHR 10282R

Target: COX

Cat No.	Product Name	Synonyms	Targets
T6S0077	Byakangelicol		COX
	1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...		COX
TN1723	Hamaudol		COX
	Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 activities with values of 0.30, 0.57 mM, respectively.		COX
T3883	Roburic acid		COX
	Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.		COX
TQ0288	Hexahydrocurcumin		Reactive Oxygen Species , ROS , COX
	Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.		Reactive Oxygen Species , ROS , COX
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T6S2023	Harpagoside		Others , COX , NO Synthase
	1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression...		Others , COX , NO Synthase
TQ0180	Chebulagic acid		SARS-CoV , Influenza Virus , Lipoxygenase , COX
	Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.		SARS-CoV , Influenza Virus , Lipoxygenase , COX
T8240	Cis-5-Dodecenoic Acid		Others
	Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position.		Others
T4S0590	Columbin		Phospholipase , COX , Parasite
	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.		Phospholipase , COX , Parasite
T3877	Esculentoside A		NF-κB , COX
	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun...		NF-κB , COX
T3747	Syringaldehyde	Syringic aldehyde,Springaldehyde	COX
	syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity wi...		COX
T8255	(±)-Catechin	(±)-Catechin hydrate	ROS , COX
	(±)-Catechin ((±)-Catechin hydrate) hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.		ROS , COX
T7052	Gnetol		Tyrosinase , COX , HDAC , AChR
	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...		Tyrosinase , COX , HDAC , AChR
T2972	Rutaecarpine	Rutacarpine,Rhetine,Rutecarpine	COX
	Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.		COX
T2778	(+)-Catechin Hydrate		Antioxidant , COX
	(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems.		Antioxidant , COX
T6S0413	Pectolinarigenin	Pectolinaringenin	Others , Lipoxygenase , COX
	1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ...		Others , Lipoxygenase , COX
T5430	[8]-Shogaol	8-SHOGAOL	Apoptosis , COX
	[8]-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.		Apoptosis , COX
T4643	TFAP	N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX , Endogenous Metabolite
	TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor		COX , Endogenous Metabolite
T2826	Asaraldehyde	Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde	COX
	Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde), a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1.		COX
T5431	[10]-Shogaol	10-Shogaol	Antioxidant , COX
	[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects.		Antioxidant , COX
T3866	Macelignan	Anwuligan,(+)-Anwulignan	Others , COX
	Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species.		Others , COX
T7113	Paradol	6-paradol,[6]-Gingerone	COX
	Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activit...		COX
T0443	Salicin	Salicoside,Salicine,D-(−)-Salicin	COX
	Salicin (Salicine), a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions.		COX
T0649	Salicylic acid	2-Hydroxybenzoic acid	Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
TQ0169	Inulicin	1-O-Acetylbritannilactone	FAK , NF-κB , COX , Src
	Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.		FAK , NF-κB , COX , Src
T3399	Psoralidin		Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T3342	Xanthohumol		Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV
	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ...
T5759	S-(+)-Marmesin	(+)-Marmesin,(S)-Marmesin,marmesin	Lipoxygenase , COX
	S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.		Lipoxygenase , COX
T6S1543	Dehydrodiisoeugenol		Others , NF-κB , COX , Antibacterial
	1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ...		Others , NF-κB , COX , Antibacterial
T3744	Veratric acid	Veratrumenoic acid,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species , COX
	Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.		Reactive Oxygen Species , COX
T2856	(-)-Epicatechin	L-Epicatechin,Epicatechin,(-)-Epicatechol	Ferroptosis , COX , Endogenous Metabolite
	(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.		Ferroptosis , COX , Endogenous Metabolite
T5727	CAFESTOL		ERK , NF-κB , COX , PGE Synthase
	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production...		ERK , NF-κB , COX , PGE Synthase
TN2139	Regaloside B		NOS , COX , NO Synthase
	Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2).		NOS , COX , NO Synthase
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
T6S0722	Isoorientin	Homoorientin,Luteolin-6-C-glucoside	Antioxidant , COX
	Isoorientin (Homoorientin) has antioxidant activity.		Antioxidant , COX
T1468	Lornoxicam	Ro 13-9297,Chlortenoxicam,TS110	COX , Endogenous Metabolite
	Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam co...		COX , Endogenous Metabolite
T3S0645	N-trans-Feruloyltyramine	Feruloyltyramine,N-Feruloyltyramine,Moupinamide	Others , COX
	1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...		Others , COX
T2S2335	Dehydroevodiamine	DHED	Others , NF-κB , COX , PGE Synthase , NO Synthase
	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl...		Others , NF-κB , COX , PGE Synthase , NO Synthase
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T8293	γ-Tocopherol	(+)-γ-Tocopherol	COX
	(+)-γ-Tocopherol ((+)-γ-Tocopherol) is one of the naturally occurring forms of Vitamin E. It is the most abundant Tocopherol in soybean and corn oils.		COX
TN1377	α-Spinasterol	alpha-Spinasterol	COX , Antibacterial , TRP/TRPV Channel
	α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v...		COX , Antibacterial , TRP/TRPV Channel
T0822	Catechin	Catechinic acid,D-Catechin,(+)-Catechin,Cianidanol,Catechuic acid	Apoptosis , Influenza Virus , COX , Endogenous Metabolite
	Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant.		Apoptosis , Influenza Virus , COX , Endogenous Metabolite
TN1373	α-Humulene	Alpha-caryophyllene	TNF , NOS , COX
	α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production an...		TNF , NOS , COX
T0877	Gallic acid	3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , ROS , COX , Endogenous Metabolite
	Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T5681	ETHYL CAFFEATE	ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB , COX , PGE Synthase , NO Synthase
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...		NF-κB , COX , PGE Synthase , NO Synthase
T0065	Acetaminophen	4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol	COX , Endogenous Metabolite , Histone Acetyltransferase
	Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.		COX , Endogenous Metabolite , Histone Acetyltransferase
T7030	Anemarsaponin B		p38 MAPK , NF-κB , MEK , COX , NO Synthase
	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c...		p38 MAPK , NF-κB , MEK , COX , NO Synthase
T1301	Guaiacol	O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol	NF-κB , COX , Endogenous Metabolite
	Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator...		NF-κB , COX , Endogenous Metabolite
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T7786	Tryptanthrin		DNA gyrase
	Tryptanthrin is a natural DNA gyrase inhibitor.		DNA gyrase
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Natural Products

Target: Reactive Oxygen Species, ROS, COX

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Harpagoside

T6S2023

Synonym:

Target: Others, COX, NO Synthase

Chebulagic acid

TQ0180

Synonym:

Target: SARS-CoV, Influenza Virus, Lipoxygenase, COX

Cis-5-Dodecenoic Acid

Target: Phospholipase, COX, Parasite

Synonym: Syringic aldehyde,Springaldehyde

Target: COX

(±)-Catechin

T8255

Synonym: (±)-Catechin hydrate

Target: Tyrosinase, COX, HDAC, AChR

Rutaecarpine

T2972

Synonym: Rutacarpine,Rhetine,Rutecarpine

Target: Antioxidant, COX

Pectolinarigenin

T6S0413

Synonym: Pectolinaringenin

Target: Others, Lipoxygenase, COX

[8]-Shogaol

T5430

Synonym: 8-SHOGAOL

Target: Apoptosis, COX

TFAP

T4643

Synonym: N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

Target: COX, Endogenous Metabolite

Asaraldehyde

T2826

Synonym: Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde

Target: Antioxidant, COX

Macelignan

T3866

Synonym: Anwuligan,(+)-Anwulignan

Target: Others, COX

Paradol

T7113

Synonym: 6-paradol,[6]-Gingerone

Target: COX

Salicin

T0443

Synonym: Salicoside,Salicine,D-(−)-Salicin

Target: COX

Salicylic acid

T0649

Synonym: 2-Hydroxybenzoic acid

Target: Apoptosis, Mitophagy, COX, Endogenous Metabolite, Autophagy

Inulicin

TQ0169

Synonym: 1-O-Acetylbritannilactone

Target: FAK, NF-κB, COX, Src

Psoralidin

T3399

Synonym:

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Xanthohumol

T3342

Synonym:

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

S-(+)-Marmesin

T5759

Synonym: (+)-Marmesin,(S)-Marmesin,marmesin

Target: Lipoxygenase, COX

Dehydrodiisoeugenol

T6S1543

Synonym:

Target: Others, NF-κB, COX, Antibacterial

Veratric acid

T3744

Synonym: Veratrumenoic acid,3,4-Dimethoxybenzoic acid

Target: Reactive Oxygen Species, COX

(-)-Epicatechin

T2856

Synonym: L-Epicatechin,Epicatechin,(-)-Epicatechol

Target: Ferroptosis, COX, Endogenous Metabolite

CAFESTOL

T5727

Synonym:

Target: ERK, NF-κB, COX, PGE Synthase

Regaloside B

TN2139

Synonym:

Target: NOS, COX, NO Synthase

sphondin

T5758

Synonym:

Target: COX, Prostaglandin Receptor

Isoorientin

T6S0722

Synonym: Homoorientin,Luteolin-6-C-glucoside

Target: Antioxidant, COX

Lornoxicam

T1468

Synonym: Ro 13-9297,Chlortenoxicam,TS110

Target: COX, Endogenous Metabolite

N-trans-Feruloyltyramine

T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide

Target: Others, NF-κB, COX, PGE Synthase, NO Synthase

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

γ-Tocopherol

T8293

Synonym: (+)-γ-Tocopherol

Target: COX

α-Spinasterol

TN1377

Synonym: alpha-Spinasterol

Target: COX, Antibacterial, TRP/TRPV Channel

Catechin

T0822

Synonym: Catechinic acid,D-Catechin,(+)-Catechin,Cianidanol,Catechuic acid

Target: Apoptosis, Influenza Virus, COX, Endogenous Metabolite

α-Humulene

TN1373

Synonym: Alpha-caryophyllene

Target: TNF, NOS, COX

Gallic acid

T0877

Synonym: 3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid

Target: Apoptosis, Ferroptosis, Reactive Oxygen Species, ROS, COX, Endogenous Metabolite

ETHYL CAFFEATE

T5681

Synonym: ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

Acetaminophen

T0065

Synonym: 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol

Target: COX, Endogenous Metabolite, Histone Acetyltransferase

anemarsaponin B

T7030

Synonym:

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Guaiacol

T1301

Synonym: O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol

Target: NF-κB, COX, Endogenous Metabolite

Isofraxidin

T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,Phytodolor

Target: MMP, ERK, p38 MAPK, TLR, COX

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02900	IL-17A Protein, Mouse, Recombinant	Mouse	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-02886	IL-17A Protein, Human, Recombinant	Human	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-01736	COX-2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a perox...
TMPY-04710	IL-17 Protein, Rhesus, Recombinant	Rhesus	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-03568	IL-17A Protein, Human, Recombinant (His)	Human	Yeast
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-05183	IL-17A Protein, Human, Recombinant, Biotinylated	Human	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-04332	IL-17A Protein, Human, Recombinant (T26A, His)	Human	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-04609	IL-17 Protein, Rabbit, Recombinant (His)	Rabbit	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-03906	IL-17 Protein, Canine, Recombinant	Canine	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-03931	IL-17 Protein, Marmoset, Recombinant	Marmoset	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-04888	IL-17 Protein, Rabbit, Recombinant	Rabbit	E. coli
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-05342	IL-17A Protein, Cynomolgus, Recombinant	Cynomolgus	Baculovirus-Insect Cells
	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...