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EG36
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Catalog No. T218356 Copy Product Info
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EG36 is a selective Escherichia coli DnaK inhibitor that suppresses the ATPase activity of DnaK at a concentration of 100 μM. It binds directly to the nucleotide-binding domain (NBD) of E. coli DnaK, disrupting the interaction between DnaK and DnaJ. EG36 is applicable for research on bacterial infectious diseases.
EG36
Cas No. 2215779-34-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | EG36 is a selective Escherichia coli DnaK inhibitor that suppresses the ATPase activity of DnaK at a concentration of 100 μM. It binds directly to the nucleotide-binding domain (NBD) of E. coli DnaK, disrupting the interaction between DnaK and DnaJ. EG36 is applicable for research on bacterial infectious diseases. |
| In vitro | EG36 (50-200 μM) inhibits the DnaJ-GrpE-stimulated ATPase activity of purified E. coli DnaK in a dose-dependent manner, with inhibitory effects observed at concentrations of 50, 100, and 200 μM. The inhibition becomes more pronounced as the concentration of DnaJ increases. EG36 directly binds to the isolated nucleotide-binding domain of E. coli DnaK, thus suppressing its intrinsic ATPase activity. However, EG36 is not a general Hsp inhibitor, as it does not alter the ATPase activity or thermal stability of bacterial HtpG. |
| Molecular Weight | 624.74 |
| Formula | C37H41FN4O4 |
| Cas No. | 2215779-34-1 |
| Smiles | O=C1C2=CC=CC(=C2)CC3=CC(=CC=C3OCCN(CCN1C)CC4(O)CCN(C=5C=CC=CC5OC)CC4)C=6C=NC(F)=CC6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: EG36 in vitro | EG36 formula | EG36 molecular weight
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