PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.

Cat. No.	Product name	CAS No.	Purity
TN3160	6-Deoxyisojacareubin	26486-92-0	98%
TN3160	6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibiti...
TN3655	Cimiside E	154822-57-8	98%
TN3655	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
T16671	PS315	1221964-50-6	98%
T16671	PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative ...
T13605	Cercosporin	35082-49-6	98%
T13605	Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelengt...
TN3517	Bisacurone	120681-81-4	98%
TN3517	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN4431	Leucosceptoside A	83529-62-8	98%
TN4431	Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidas...
TN2326	(Z)-Butylidenephthalide	72917-31-8	98%
TN2326	(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
T10555	BJE6-106	1564249-38-2	98%
T10555	BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-depende...
T16848	SB-218078	135897-06-2	98%
T16848	SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
T13384	Y-33075	199433-58-4	98%
T13384	Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
TN4300	Isojacareubin	50597-93-8	98%
TN4300	Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
T14831	Bryostatin 1	83314-01-6	98%
T14831	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
T15638	K-252c	85753-43-1	98%
T15638	K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 µM). K-252c also inhibits β-lactamase, chymotry...
T15637	K-252b	99570-78-2	98%
T15637	K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in ...
T4001	Euxanthone	529-61-3	98%
T4001	Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasod...
T16526	Phorbol 12,13-dibutyrate	37558-16-0	98%
T16526	Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
T17299	(-)-Indolactam V	90365-57-4	98%
T17299	(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-...
T14328	AS2521780	1214726-89-2	98%
T14328	AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
T5423	PKC-theta inhibitor	736048-65-0	98%
T5423	PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.
TN2799	20-Deoxyingenol 3-angelate	75567-38-3	98%
TN2799	20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant pl...