PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.

Cat No.	product name
T6278	SotrastaurinHOT	Sotrastaurin is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).
TP1956L	PKC ζ pseudosubstrate acetate	PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of am...
T5817	PKC-theta inhibitor hcl	PKC-theta inhibitor is a selective PKC-θinhibitor(IC50:12 nM).
T6285	GSK690693	GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
T4037	Phorbol	Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.
T4391	Syk Inhibitor II (hydrochloride)	Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chai...
T6S0052	Chelerythrine	1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. C...
T7501	Iso-H7 dihydrochloride	Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.
T5S2017	Ingenol	1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develo...
T3S1416	Decursin	1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , ...
T4950	1,2-Dipalmitoyl-sn-glycerol	1,2-Dipalmitoyl-sn-glycerol is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.
T5239	Cholesterol 3-Sulfate Sodium Salt	Cholesterol sulfate is a sterol sulfate in human plasma. It is a component of cell membrane and has a regulatory function. It also activates multiple protein kin...
T5600	LXS196	LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectiv...
T6588	Mitoxantrone	Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA rep...
T5771	Hypocrellin A	Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presen...
T5891	D-ERYTHRO-SPHINGOSINE	D-erythro-Sphingosine is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
T5796	Plantainoside D	Plantainoside D shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitr...
T7659	Bisindolylmaleimide IV	Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 µM)
TQ0198	Phorbol 12-myristate 13-acetate	Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
T7604	Valrubicin	Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
T7790	Bisindolylmaleimide V	Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
T7792	Hispidin	Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties
T8376	PKCβ inhibitor 1	PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKCß isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectivel...
TN1047	Ingenol mebutate	Ingenol mebutate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activity...
T2356	Ro 3306	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
T3375	Verbascoside	Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T6680	Staurosporine	Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
T6280	Enzastaurin	Enzastaurin (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.
T1606	Fasudil	Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T3060	Fasudil hydrochloride	Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T0228	Methyl hesperidin	Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
T3050	ML-7 hydrochloride	ML-7 Hcl is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-musc...
T3211	Midostaurin	PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelia...
T3684	CP21R7	CP21R7 is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smooth...
T6513	Bisindolylmaleimide I	GF109203X is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.
T6313	Go 6983	Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
T6643	Ro 31-8220 Mesylate	Ro 31-8220 is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β...
T3689	Ruboxistaurin hydrochloride	Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). S...
T2757	Myricetrin	Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
TN1299	6,7,4'-Trihydroxyisoflavone	6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer act...
T2441	TAS301	TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.
T6932	PD168393	PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
T6605	NH125	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T6167	SU9516	SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
T3419	Chelerythrine chloride	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ...
T0465	Ellagic acid	Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T2851	Daphnetin	Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM...
T0979	Dequalinium chloride	Dequalinium Chloride, a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may ...
T0033	Miltefosine	Miltefosine is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agen...
T1648	Vitamin E	(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
TN1136	Procyanidin A1	Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 ce...
TN1513	Clitorin	Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.
TP1887L1	[Ala107]-MBP (104-118) acetate(99026-77-4 free base)	[Ala107]-MBP (104-118) acetate is synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).
TN4271	Isochamaejasmine	Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the ...
T17148	TPPB	TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
T17299	(-)-Indolactam V	(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 n...
T4001	Euxanthone	Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasod...
TN2799	20-Deoxyingenol 3-angelate	20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant pl...
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such...
TN3160	6-Deoxyisojacareubin	6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibiti...
TN3517	Bisacurone	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN3655	Cimiside E	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
TN3694	Coniferaldehyde	Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1), it inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dep...
TN4114	Gardenin A	Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, bu...
TN4300	Isojacareubin	Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
T16848	SB-218078	SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
TN4431	Leucosceptoside A	Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosida...
T8764	PKC-iota inhibitor 1	PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T8681	HA-1004 dihydrochloride	HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
T8681	HA-1004 dihydrochloride	HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
T20168	Sodium aurothiomalate	Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor...
TP1789L	Malantide acetate(86555-35-3 free base)	Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide tha...
TP1053L	Protein Kinase C 19-31 acetate(121545-65-1 free base)	Protein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with ...
TP1945L1	Pep2m, myristoylated acetate(1423381-07-0 free base)	Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA rec...
TP1924L1	ZIP acetate(863987-12-6 free base)	ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Select...
T17019	TCS 21311	TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectivel...
T16791	Rottlerin	Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,...
TN1542	Cycloheterophyllin	Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
T14943	CGP60474	CGP60474 is an inhibitor of VEGFR-2 (IC50: 84 nM) and an ATP-competitive inhibitor of PKC.
TN1557	Decursinol angelate	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of th...
TN2326	(Z)-Butylidenephthalide	(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
T12494	PKC-IN-1	PKC-IN-1 is a ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7...
T12496	PKC-theta inhibitor 1	PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)
T10888	CRT0066854 hydrochloride	CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 va...
T13637	DCP-LA	DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.
T10980	DCPLA-ME	DCPLA-ME is the methyl ester form of DCPLA and can be used to treat neurodegenerative diseases. It is an effective PKCε activator.
T14069	A-3 hydrochloride	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T14328	AS2521780	AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
T14831	Bryostatin 1	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
T14989	CMPD101	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
T16671	PS315	PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivat...
T10549	Bisindolylmaleimide VIII acetate	Bisindolylmaleimide VIII acetate is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-...
T10550	Bisindolylmaleimide X hydrochloride	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
T10555	BJE6-106	BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-dep...
T13314	VTX-27	VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).
T13605	Cercosporin	Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelengt...
T15637	K-252b	K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in ...
T15638	K-252c	K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 µM). K-252c also inhibits β-lactamase, chymot...
T13384	Y-33075	Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
T13363	Y06137	Y06137 is a potent and selective inhibitor of BET, and used for treatment of castration-resistant prostate cancer (CRPC). Y06137 binds to the BRD4(1) bromodomain...
T11740	Delcasertib	Delcasertib is a potent and selective inhibitor of δ-protein kinase C (δPKC).
T16526	Phorbol 12,13-dibutyrate	Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
T0610	Piceatannol	Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activa...