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PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
Cat. No. Product name CAS No. Purity Chemical Structure
T14328 AS2521780 1214726-89-2 98%
AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
T16526 Phorbol 12,13-dibutyrate 37558-16-0 98%
Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
TN4431 Leucosceptoside A 83529-62-8 98%
Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidas...
T16848 SB-218078 135897-06-2 98%
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
T35328 H-1152 dihydrochloride 871543-07-6 98%
TN4300 Isojacareubin 50597-93-8 98%
Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
T3689 Ruboxistaurin hydrochloride 169939-93-9 98%
Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Sele...
T10888 CRT0066854 hydrochloride 2250019-91-9 98%
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
T13605 Cercosporin 35082-49-6 98%
Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelengt...
T15637 K-252b 99570-78-2 98%
K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in ...
T15638 K-252c 85753-43-1 98%
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 µM). K-252c also inhibits β-lactamase, chymotry...
T5423 PKC-theta inhibitor 736048-65-0 98%
PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.
TN2799 20-Deoxyingenol 3-angelate 75567-38-3 98%
20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant pl...
TN2326 (Z)-Butylidenephthalide 72917-31-8 98%
(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
TN3655 Cimiside E 154822-57-8 98%
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
TN1542 Cycloheterophyllin 36545-53-6 98%
Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
TN3517 Bisacurone 120681-81-4 98%
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
T1606 Fasudil 103745-39-7 98%
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
TN4114 Gardenin A 21187-73-5 98%
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
T4001 Euxanthone 529-61-3 98%
Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasod...
AS2521780
T14328
AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
Phorbol 12,13-dibutyrate
T16526
Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
Leucosceptoside A
TN4431
Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidas...
SB-218078
T16848
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
H-1152 dihydrochloride
T35328
Isojacareubin
TN4300
Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
Ruboxistaurin hydrochloride
T3689
Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Sele...
CRT0066854 hydrochloride
T10888
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
Cercosporin
T13605
Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelengt...
K-252b
T15637
K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in ...
K-252c
T15638
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 µM). K-252c also inhibits β-lactamase, chymotry...
PKC-theta inhibitor
T5423
PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.
20-Deoxyingenol 3-angelate
TN2799
20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant pl...
(Z)-Butylidenephthalide
TN2326
(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
Cimiside E
TN3655
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
Cycloheterophyllin
TN1542
Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
Bisacurone
TN3517
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
Fasudil
T1606
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
Gardenin A
TN4114
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
Euxanthone
T4001
Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasod...
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