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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T60108 | PDGFR Tyrosine Kinase Inhibitor III | PDGF Receptor Tyrosine Kinase Inhibitor III | PDGFR |
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF... | |||
T71944 | FGF/PDGF/VEGF RTK Inhibitor | ||
FGF/PDGF/VEGF RTK Inhibitor is a potent, reversible, atp-competitive inhibitor against pdgfrβ, fgfr-1, and vegfr-2 (ic50 = 20, 90, and 240 nm, respectively) and effectively suppresses vegf-stimulated proliferation of h... | |||
T14137 | AG 1295 | PDGFR | |
AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4]. | |||
T15031 | CYM50260 | Others , LPL Receptor | |
CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. | |||
T6711 | Tyrphostin AG1296 | Tyrphostin AG 1296,AG 1296 | Apoptosis , FGFR , FLT , PDGFR , c-Kit |
Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. | |||
T62872 | PDGFR-IN-1 | ||
PDGFR-IN-1 (compound 7m) is an orally active PDGFR (platelet-derived growth factor receptor) inhibitor that acts on PDGFRα (IC50: 2.4 nM) and PDGFRβ (IC50: 0.9 nM). PDGFR-IN-1 exhibits strong anti-tumour effects and low ... | |||
T78843 | MET/PDGFRA-IN-1 | c-Met/HGFR | |
MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET. It impedes MET phosphorylation, thereby promoting apoptosis, and curtails the proliferation of var... | |||
T12396 | PDGFRα kinase inhibitor 1 | PDGFR | |
PDGFRα kinase inhibitor 1 is a highly selective inhibitor of type II PDGFRα kinase (PDGFRα and PDGFRβ with IC50s of 132 nM and 6115 nM , respectively). | |||
T63454 | PDGFRα/FLT3-ITD-IN-1 | ||
PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 exhibits investigational potential in acute myeloid leukemia or chr... | |||
T63629 | PDGFRα/FLT3-ITD-IN-2 | ||
PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM). PDGFRα/FLT3-ITD-IN-2 has shown investigational potential in acute myeloid leukemia or chronic eosinophilic leukemia. | |||
T63127 | PDGFRα/FLT3-ITD-IN-3 | ||
PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be studied in acute myeloid leukaemia or chronic eosinophilic leuk... | |||
T78844 | MET/PDGFRA-IN-2 | c-Met/HGFR | |
MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positive cells with IC50 values of 9.7, 6.1, 12.0, 11.5, 8.6, and 34.4 μ... | |||
T60110 | KN1022 | PDGFR | |
KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM. | |||
T38737L | SDKPDMAEIEKFDKSK acetate | SDKPDMAEIEKFDKSK acetate(1339864-27-5 free base) | Others |
SDKPDMAEIEKFDKSK acetate is a thymosin β4 derivative. Thymosin β4 inhibits PDGF-BB-induced fibrogenesis, proliferation and migration of HSC by blocking Akt phosphorylation. | |||
T6S0655 | Corynoxeine | ERK | |
1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty. | |||
T6996 | SU 5402 | SU5402 | VEGFR , FGFR , PDGFR |
SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively. | |||
TN2354 | Methylnissolin | 3-Hydroxy-9,10-dimethoxyptercarpan | ERK , PDGFR |
Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects. | |||
T2734 | Sennoside B | PDGFR | |
Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation. | |||
TN2063 | Physalin B | NSC-287088 | Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD |
Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B amel... | |||
T6429 | Caffeic Acid Phenethyl Ester | Phenylethyl Caffeate,CAPE | Apoptosis , NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective... |