glur — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9970	MGluR3 modulator-1	1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile	GluR
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease.		GluR
T12717	Basimglurant	CTEP Derivative,RG7090	GluR
	Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).		GluR
T35028	Valiglurax	VU2957,VU 0652957,VU 2957,VU-0652957,VU0652957,VU-2957	GluR
	Valiglurax (VU2957), also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro and in vivo pharmacological and DMPK properties acro...		GluR
T15090	Decoglurant	RO4995819	GluR
	Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.		GluR
T38612	Linaprazan glurate		Others
	Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate can be used in studies about gastrointestinal inflammatory diseases and peptic ulcer diseases.		Others
T9723	GluR6 antagonist-1		Src
	GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.		Src
T60882	MGluR2 modulator 2
	mGluR2 modulator 2 (compound 2) can be used in antipsychotic research. mGluR2 modulator 2 is a potent, selective and orally bioavailable positive allosteric modulator of mGluR2 with an EC 50 value of 0.13 μM [1].
T15134	Dipraglurant	ADX48621	Others
	Dipraglurant is a negative allosteric regulator (NAM) of blood-brain barrier transmissible mGluR5 with effective, selective and oral activity, with an IC50 value of 21 nM. Dipraglurant can treat levodopa-induced dyskines...		Others
T61277	MGluR2 modulator 4
	mGluR2 modulator 4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC 50 value of 0.8 μM. It holds the potential for investigating antipsychotic properties [1].
T34282	Remeglurant
	Remeglurant is used as a selective antagonist of the mGlu5 receptor.
T11951	Mavoglurant racemate	AFQ-056 racemate	Others
	Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.		Others
T32080	Histidine oxoglurate	Histidine alpha-ketoglutarate
	Histidine oxoglurate is a bioactive chemical.
T82295	GluR23Y
	GluR23Y, a biologically active peptide, was utilized in an ELISA-based cell-surface assay to assess insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y effectively inhibited t...
T80246	TAT-GluR23A Fusion Peptide
	TAT-GluR23A Fusion Peptide is a bioactive peptide comprising the GluR23A sequence—residues 869 to 877 of GluR23Y with alanine replacing tyrosine—and an 11 amino acid cell-permeable HIV Trans-Activator of Transcription (T...
T38910	MGluR2 antagonist 1
	mGluR2 antagonist 1 is a potent and selective class of negative allosteric modulator targeting the metabotropic glutamate receptor 2 (mGluR2) with high oral bioavailability. It displays a remarkable affinity for mGluR2, ...
T11311L	Foliglurax	PXT002331	GluR
	Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).		GluR
T17241	Auglurant	VU0424238	Others
	Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration.		Others
T11311	Foliglurax monohydrochloride	PXT002331 (monohydrochloride)	Others
	Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.		Others
T81801	MGluR5 antagonist-1
	mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].
T62202	MGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) is a potent, blood-brain-barrier permeable modulator of mGluR2 (metabotropic glutamate receptor-2) positive transmutation (EC50: 0.03 μM). mGluR2 modulator 1 can be used in the study of p...