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RAAS

The renin–angiotensin system (RAS), or renin–angiotensin–aldosterone system (RAAS), is a hormone system that regulates blood pressure and fluid and electrolyte balance, as well as systemic vascular resistance.

  • Angiotensin II human
    T70404474-91-3
    Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthesis and renal activity in humans.
    • $37
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  • Irbesartan
    T1615138402-11-6
    Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.
    • $48
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  • Tranilast
    T269053902-12-8
    Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.
    • $36
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  • Sacubitril/Valsartan
    T2318936623-90-4
    Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
    • $38
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  • Captopril
    T146262571-86-2
    Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.
    • $40
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  • [Sar1, Ile8]-Angiotensin II acetate
    T7575L1
    [Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascular smooth muscle, including contra
    • $37
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  • L-162,313
    T27762151488-11-8In house
    L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP.
    • $350
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  • TRV-120027 acetate (1234510-46-3 free base)
    TP2158L11824712-70-0
    TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling.
    • $100
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  • Novokinin acetate
    T23077L
    Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.
    • $237
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  • Angiotensin I/II (1-5)
    TP152858442-64-1
    Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.
    • $50
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  • ANGIOTENSIN IV TFA(12676-15-2(free base))
    T7743
    ANGIOTENSIN IV TFA is a less effective agonist at the angiotensin AT1 receptor.
    • $43
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  • Ripisartan
    T28540148504-51-2In house
    Ripisartan (UP-269-6) is a potent and specific angiotensin II receptor antagonist that inhibits angiotensin II-mediated sympathetic tachycardia responses.
    • $191
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  • Pomisartan
    T28437144702-17-0In house
    Pomisartan (BIBR-363) is a small molecule angiotensin type 1 receptor (AT1R) antagonist that is used in the treatment of cardiovascular disease, studying heart failure and hypertensio
    • $143
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  • Terlakiren
    T28950119625-78-4In house
    Terlakiren (CP-80,794) is an orally active and potent renin inhibitor that inhibits the potency of human renin for the study of neurological disorders of the hypertension class.
    • $628
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  • FPL-62129
    T2735795445-79-7In house
    FPL-62129 is a calcium channel antagonist and a novel angiotensin-converting enzyme inhibitor with vasodilator activity for the study of cardiovascular disease.
    • $293 TargetMol
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  • Ceronapril
    T25226111223-26-8In house
    Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.
      6-8weeks
      Inquiry
    • Acein acetate
      TP1920L1
      Acein acetate is a high-affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Concentrations up to 500 nM had no significant effect on ACE enzyme activity. Enhanced NMDA + D-serine-induced dopamine release from striatal slices in vitro and striatum in vivo.
      • $133
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    • Alamandine TFA
      T37496L
      Alamandine TFA , a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine TFA targets to protect the kidney and heart through anti-hypertensive actions[1][2].
      • $55
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    • Angiotensin II 5-valine TFA
      TP1017L
      Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
      • $53
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    • A 779 TFA(159432-28-7 free base)
      T7616L
      A 779 TFA is a potent antagonist of angiotensin-(1-7) receptor.
      • $50
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    • Enalapril
      T160575847-73-3
      Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
      • $30
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    • N-Acetyl-Ser-Asp-Lys-Pro
      TP1828127103-11-1
      Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice.
      • $50
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    • ME-3221
      T28009139958-16-0
      ME-3221 is an angiotensin AT1 receptor antagonist that prevents hypertensive complications in aged stroke-prone hypertensive rats.
      • $293 TargetMol
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    • Azilsartan Methyl Ester
      T66580147403-52-9
      Azilsartan Methyl Ester is an angiotensin II receptor antagonist. Azilsartan Methyl Ester inhibits specific binding of [125I]AII (0.2 nM) to bovine adrenal cortex with IC50 value is 0.44uM.
      • $62
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    • Pomisartan 2HCl
      T28437L In house
      Pomisartan 2HCl (BIBR363 2HCL) is a small molecule AT1R antagonist used to study heart failure and hypertension.
      • $195
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    • Leucylarginylproline
      T7510133943-59-6
      Leucylarginylproline is an inhibitor of angiotensin-converting enzyme (ACE) (IC50 : 0.27μM).
      • $89
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    • TRV055 acetate
      T40220L
      TRV055 acetate is a ligand of angiotensin II type 1 receptor and stimulates cellular Gq-mediated signaling.
      • $195
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    • Methyl candesartan
      T65739139481-69-9
      Methyl candesartan (Candesartan Methyl Ester) is a potent angiotensin 2 receptor antagonist used in the study of hypertension.
      • $43
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    • Angiotensin 1/2 (5-7) acetate
      T22574L
      Angiotensin 1/2 (5-7) acetate is a peptide with the sequence H2N-Ile-His-Pro-OH. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It
      • $37
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    • CGP-42112 acetate
      T14939L
      CGP-42112 acetate is a potent angiotensin receptor AT2 agonist that inhibits the increase in protein kinase A activity produced by LPS.
      • $127
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    • (Sar¹)-Angiotensin II acetate
      T35834L
      (Sar¹)-Angiotensin II acetate, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles, with a Kd of 2.7 nM. It can stimulate protein synthesis and cell growth in embryonic chick myocytes.
      • $148
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    • Valsartan Methyl Ester
      T67848137863-17-3
      Valsartan Methyl Ester is a potent angiotensin II receptor antagonist, IC50= 0.06uM.
      • $64
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    • Angiotensin I/II (1-6)
      TP157947896-63-9
      Angiotensin I/II (1-6) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS) that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide.
      • $50
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    • Moveltipril
      T2583285856-54-8In house
      Moveltipril (Moveltipril calcium) is a potent angiotensin-converting enzyme (ACE) inhibitor.Moveltipril is converted to captopril in the body for action.
      • $83
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    • Allisartan Isoproxil
      T26594947331-05-7In house
      Allisartan Isoproxil is a nonpeptide antagonist of angiotensin II receptor and can be used in studies about hypertension and heart diseases.
      • $195
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    • Cilazapril Monohydrate
      T644492077-78-6In house
      Cilazapril Monohydrate (Justor) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.
      • $58
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    • Sinapinic Acid
      T3753530-59-6
      Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinapic acid with antioxidant role protects cardiac cells and its functions from I/R induced oxidative stress. Sinapic acid is a potentially useful agent for the protection against liver fibrosis and cirrhosis. Sinapic acid prevents the alterations in the levels of lipids and lipoproteins by virtue of its anti-lipidaemic effect in isoproterenol induced myocardial infarcted rats. Sinapic acid ameliorates hyperglycemia through PLC-PKC signals to enhance the glucose utilization in diabetic rats.
      • $29
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    • Losartan
      T0215L114798-26-4
      Losartan (DuP-753) is an angiotensin II receptor antagonist.
      • $50
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    • PD 123319
      T6067130663-39-7
      PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.
      • $45
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    • Peimisine
      T5S010619773-24-1
      1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Peimisine can attenuate lung tissue injury( ALI), LDH and MDA amount in ALI mice in a dose dependent manner, it also lower the total protein, total white blood cells, lymphocyte and neutrophilic leukocyte in bronchoalveolar lavage fluid( BALF); suggests that peimisine can play a protective role against LPS-induced acute lung injury. 3. Peimisine has the protective effect on the experimental hepatic fibrosis formation, the possible mechanisms are associated with inhibiting fibrogenesis and fibrosis accumulation, and decreasing lipid peroxidation. 4. Peimisine can inhibit angiotensin I converting enzyme activity in a dose-dependent manner, displaying 5 % inhibitory concentration values of 526.5 microM, thus, it may have antihypertensive action.
      • $60
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    • Telmisartan
      T1570144701-48-4
      Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist.
      • $41
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    • Vicenin 2
      T385123666-13-9
      Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants.
      • $79
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    • Valsartan
      T6716137862-53-4
      Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.
      • $46
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    • Angiotensin II human acetate
      T856068521-88-0
      Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor.
      • $33
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    • A 779
      T7616159432-28-7
      A 779 is a potent antagonist of the G-protein-coupled receptor Mas, the Ang1-7 receptor, which is distinct from conventional AngII.
      • $268
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    • Azilsartan
      T1057147403-03-0
      Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pressure.
      • $30
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    • C-Type Natriuretic Peptide (CNP) (1-22), human
      TP1187127869-51-6
      C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide.
      • $122
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    • DX600 TFA
      TP1622
      DX600 TFA is a specific inhibitor of ACE2 and does not cross-react with ACE.
      • $163
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    • Azilsartan Medoxomil
      T6219863031-21-4
      Azilsartan Medoxomil (TAK-491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
      • $34
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    • Perindoprilat
      T148495153-31-4
      Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.
      • $37
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