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Novokinin acetate

Name: Novokinin acetate
Brand: TargetMol
SKU: T23077L
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23077L

Alias Novokinin acetate (358738-77-9 free base)

Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.

Novokinin acetate

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Purity: 99.37%

Catalog No. T23077LAlias Novokinin acetate (358738-77-9 free base)

Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$142	-	In Stock
2 mg	$196	-	In Stock
5 mg	$320	-	In Stock
10 mg	$461	-	In Stock
25 mg	$713	-	In Stock
50 mg	$948	-	In Stock
100 mg	$1,290	-	In Stock
200 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$513	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.37%

Appearance:Solid

Color:White

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COA MS

Product Introduction

Bioactivity

Description	Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.
Targets&IC50	AT2:7 nM(Ki)
In vitro	Novokinin relaxed a mesenteric artery isolated from the spontaneously hypertensive rat (SHR) at 10(-5) M, and reduced SHR blood pressure at a dose of 0.1 mg/kg (po.) emulsified in 30% egg yolk[1].
In vivo	The hypotensive effect of novokinin in normotensive mice was not observed in the AT2 receptor-knockout mice. Its antihypertensive and vasorelaxing activities in SHR were also blocked by CAY-10441, an antagonist of the IP receptor for prostaglandin I2 PGI2 suggesting that these activities are mediated by the AT2 receptor, followed by the prostaglandin I2-IP receptor pathway. Novokinin suppressed food intake after icv. or po. administration in mice. The anorexigenic activity was not observed in the AT2 receptor- knockout mice, but was observed in the AT 1 receptor-knockout mice. The anorexigenic activities of novokinin and angiotensin II were blocked by PD123319, and ONO-AE3-208, an antagonist of the EP4 receptor suggesting that the anorexigenic activities of the AT2 agonists are mediated by the PGE 2-EP4 receptor pathway downstream of the AT2 receptor. Novokinin given icv. in mice antagonized the antinociceptive effect of morphine[1].
Synonyms	Novokinin acetate (358738-77-9 free base)

Chemical Properties

Molecular Weight	856.02
Formula	C₄₁H₆₅N₁₁O₉
Smiles	CC(C)C[C@@H](C(N[C@@H](CCCCN)C(N(CCC1)[C@@H]1C(N[C@@H](Cc1c[nH]c2c1cccc2)C(O)=O)=O)=O)=O)NC([C@H](CCC1)N1C([C@H](CCCNC(N)=N)N)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	Arg-Pro-Leu-Lys-Pro-Trp
Sequence Short	RPLKPW

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13 mg/mL (15.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1682 mL	5.8410 mL	11.6820 mL	58.4099 mL
5 mM	0.2336 mL	1.1682 mL	2.3364 mL	11.6820 mL
10 mM	0.1168 mL	0.5841 mL	1.1682 mL	5.8410 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc