P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
TMA0164	15-Hydroxydehydroabietic acid	54113-95-0	98%
TMA0164	15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
TN2687	2,3',4,6-Tetrahydroxybenzophenone	26271-33-0	98%
TN2687	2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity.
TN3379	Allocryptopine	24240-04-8	98%
TN3379	Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; it increases mRNA levels of cyto...
TN1378	Alpha-Viniferin	62218-13-7	98%
TN1378	Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities.
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate	67667-71-4	98%
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
TN3147	6',7'-Dihydroxybergamottin	264234-05-1	98%
TN3147	6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate	83182-58-5	98%
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ...
TN3875	Dipterocarpol	471-69-2	98%
TN3875	Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TN4130	Germacrone 4,5-epoxide	92691-35-5	98%
TN4130	(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
TN3627	Chalepensin	13164-03-9	98%
TN3627	Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
T10688	Casopitant mesylate	414910-30-8	98%
T10688	Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
TQ0296	N-Nornuciferine	4846-19-9	98%
TQ0296	N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).
T10535L	BI 653048 phosphate	1198784-97-2	98%
T10535L	BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
TN2144	Resveratroloside	38963-95-0	98%
TN2144	Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
TN1748	Humantenirine	82375-30-2	98%
TN1748	Standard reference
TN1210	2-Hydroxy-1-Methoxyaporphine	33770-27-3	98%
TN1210	2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
TN3080	5,6,7-Trimethoxycoumarin	55085-47-7	98%
TN3080	5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp l...
TN4928	Rutacridone	17948-33-3	98%
TN4928	Rutacridone has mutagenicity.
T16739	RG-12525	120128-20-3	98%
T16739	RG-12525 is a PPAR-gamma agonist (IC50: appr 60 nM) and a potent inhibitor of CYP3A4 (Ki: 0.5 µM). RG-12525 is a specific and competitive antagonist of the pepti...
TQ0276	Methysticin	20697-20-5	98%
TQ0276	Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.