mycobacterium

Mycobacterium bovisbacterialprotein is a member of Mycobacterium tuberculosis, responsible for causing tuberculosis in cattle.

2,6-Dimethoxybenzaldehyde inhibits the survival of J-774 cells and Mycobacterium tuberculosis and can be used in the study of tuberculosis.

Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lopez, J.A.V., Nogawa, T., Futamura, Y., et al.Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647J. Antibiot. (Tokyo)72(12)991-995(2019) 2.Ishida, S., Arai, M., Niikawa, H., et al.Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium speciesBiol. Pharm. Bull.34(6)917-920(2011) 3.Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al.Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activityMicrobiol. Res.166(8)654-661(2011) 4.Matsubara, K., Sakuda, S., Tanaka, M., et al.Morphological changes in insect BM-N4 cells induced by nocardamineBiosci. Biotechnol. Biochem.62(10)2049-2051(1998)

2',3'-Dideoxy-5-iodocytidine, a chemical compound, is employed in gene sequencing and functions as an antibiotic. It exhibits significant efficacy specifically against Mycobacterium.

Poloxamer 184 L64 is a block polymer formed from polyoxyethylene and polyoxypropylene with an average molecular weight of 2900.Poloxamer 184 L64 is toxic to the skin in the short term, as evidenced by mild erythema and intradermal inflammatory reactions. This compound exhibits antimicrobial activity, inhibiting 60% of Mycobacterium avium at a concentration of 1 mg/mL.Poloxamer 184 L64 forms thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering.

Poloxamer 333 P103 is a block copolymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 4950. It exhibits antibacterial activity, inhibiting 90% of Mycobacterium avium at a concentration of 1 mg/mL. The compound forms a thermoreversible hydrogel and is used as a food additive, as well as a drug delivery carrier in cosmetics, pharmaceuticals, and tissue engineering.

Poloxamer 335 P105 is a block copolymer composed of polyoxyethylene and polyoxypropylene, with an average molecular weight of 6500. At a concentration of 1 mg/mL, it exhibits antibacterial properties by inhibiting 86% of Mycobacterium avium. Meanwhile, Poloxamer 334 P104 has muscle toxicity and forms thermoreversible hydrogels, making it useful as a food additive and a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering.

Poloxamer 122 L42 is a block copolymer of polyethylene oxide and polypropylene oxide, with an average molecular weight of 1630. It exhibits antibacterial activity, inhibiting 56% of Mycobacterium avium at a concentration of 1 mg/mL. Poloxamer 122 L42 can form thermoreversible hydrogels and is employed as a food additive, and serves as a drug delivery carrier in cosmetics, pharmaceuticals, and tissue engineering.

Poloxamer 181 L61 is a block copolymer composed of polyoxyethylene and polyoxypropylene, with an average molecular weight of 2000. It exhibits antimicrobial activity and can inhibit 91% of Mycobacterium avium at a concentration of 1 mg/mL. Poloxamer 181 L61 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering.

Poloxamer 183 L63 is a block copolymer of polyoxyethylene and polyoxypropylene, with an average molecular weight of 2000. It demonstrates antibacterial activity by inhibiting 83% of Mycobacterium avium at a concentration of 1 mg/mL. Poloxamer 183 L63 can form thermoreversible hydrogels and is used as a food additive, as well as a drug delivery carrier in cosmetics, pharmaceuticals, and tissue engineering.

5-Fluoroindole is an antimicrobial agent known to inhibit Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of 4.7 μM. It demonstrates metabolic stability in rat liver microsomes and exhibits antitubercular activity in mice.