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N-Boc-Val-Dil-Dap-Doe is used in the synthesis of Dolastatin 10, a potent antimitotic peptide that inhibits tubulin polymerization.

Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin.

Boc-Val-Dil-Dap-OH is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs), facilitating the connection between the antibody and the therapeutic drug [1].

Boc-NMe-Val-Val-Dil-Dap-OH serves as a cleavable ADC linker, facilitating the synthesis of antibody-drug conjugates (ADCs).

Boc-Val-Dil-Dap-Phe-OMe serves as a cleavable ADC linker in the production of antibody-drug conjugates (ADCs) [1].

Dov-Val-Dil-OH is an ADC (Antibody-Drug Conjugate) toxin.

(S)-Carvedilol is a non-selective β α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

Levosemotiadil(SA 3212) is a novel calcium antagonist and a very potent inhibitor of low-density lipoprotein oxidation.Levosemotiadil may be used to prevent lethal cardiac arrhythmias.

Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.

Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.

Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.

Terodiline is a seconal amine with anticholinergic and calcium antagonistic properties that blocks the hERG current (IC50: 375 nM).Terodiline is cardiotoxic and has been used in the study of disorders caused by urethral muscle instability.

Carprazidil is a potent vasodilator used to treat severe hypertension and mild heart failure.

Flosatidil is a small molecule voltage-gated calcium channel complex (VDCCs) blocker for the treatment of neurological disorders and cardiovascular diseases, and can be used in the study of angina pectoris.

Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.

Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist.

Diltiazem hydrochloride (RG 83606 HCl) is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.

Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.

Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.

Naftopidil (KT-611) (INN, marketed under the brand name Flivas), an antihypertensive medicine, is used as a selective α1-adrenergic receptor antagonist or α-blocker.

Ifenprodil is a selective NMDA receptor (glutamate) antagonist.

Carvedilol EP IMpurity E (Carvedilol USP E) is used as a pharmaceutical intermediate.

Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.